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Senotherapeutic drugs for human intervertebral disc degeneration and low back pain

eLife, 2020-08, Vol.9

2020

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3D-Printed ABS and PLA Scaffolds for Cartilage and Nucleus Pulposus Tissue Regeneration

International journal of molecular sciences, 2015-07, Vol.16 (7), p.15118-15135

2015

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Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain

Nature communications, 2022-02, Vol.13 (1), p.843-843, Article 843

2022

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Inflammatory Mediators in Intervertebral Disk Degeneration and Discogenic Pain

Global Spine Journal, 2013-06, Vol.3 (3), p.175-184

2013

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Three-Dimensional Printed Polylactic Acid Scaffolds Promote Bone-like Matrix Deposition in Vitro

ACS applied materials & interfaces, 2019-05, Vol.11 (17), p.15306-15315

2019

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Single-Cell RNA-Seq Analysis of Cells from Degenerating and Non-Degenerating Intervertebral Discs from the Same Individual Reveals New Biomarkers for Intervertebral Disc Degeneration

International journal of molecular sciences, 2022-04, Vol.23 (7), p.3993

2022

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Automated biofabrication of anisotropic dense fibrin gels accelerate osteoblastic differentiation of seeded mesenchymal stem cells

Journal of materials research, 2021-12, Vol.36 (24), p.4867-4882

2021

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Physiological loading can restore the proteoglycan content in a model of early IVD degeneration

PloS one, 2014-07, Vol.9 (7), p.e101233-e101233

2014

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Toll-like receptor 2 induced senescence in intervertebral disc cells of patients with back pain can be attenuated by o-vanillin

Arthritis research & therapy, 2021-04, Vol.23 (1), p.117-14, Article 117

2021

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DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

eLife, 2020-12, Vol.9

2020

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Uncovering the secretome of mesenchymal stromal cells exposed to healthy, traumatic, and degenerative intervertebral discs: a proteomic analysis

Stem cell research & therapy, 2021-01, Vol.12 (1), p.11-11, Article 11

2021

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DNA Methylation of SPARC and Chronic Low Back Pain

Molecular pain, 2011-08, Vol.7 (1), p.65-65

2011

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Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro

Journal of clinical medicine, 2019-03, Vol.8 (4), p.433

2019

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o-Vanillin Modulates Cell Phenotype and Extracellular Vesicles of Human Mesenchymal Stem Cells and Intervertebral Disc Cells

Cells (Basel, Switzerland), 2022-11, Vol.11 (22), p.3589

2022

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Development of an Organ Culture System for Long-Term Survival of the Intact Human Intervertebral Disc

Spine (Philadelphia, Pa. 1976), 2011-10, Vol.36 (22), p.1835-1842

2011

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The C-terminal Peptide of Chondroadherin Modulates Cellular Activity by Selectively Binding to Heparan Sulfate Chains

The Journal of biological chemistry, 2013-01, Vol.288 (2), p.995-1008

2013

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Organ culture bioreactors--platforms to study human intervertebral disc degeneration and regenerative therapy

Current stem cell research & therapy, 2015-01, Vol.10 (4), p.339

2015

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The Inflammatory Milieu of the Degenerate Disc: Is Mesenchymal Stem Cell-based Therapy for Intervertebral Disc Repair a Feasible Approach?

Current stem cell research & therapy, 2015-01, Vol.10 (4), p.317

2015

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Optimizing Design Parameters of PLA 3D-Printed Scaffolds for Bone Defect Repair

Surgeries, 2022-09, Vol.3 (3), p.162-174

2022

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Low-frequency high-magnitude mechanical strain of articular chondrocytes activates p38 MAPK and induces phenotypic changes associated with osteoarthritis and pain

International journal of molecular sciences, 2014-08, Vol.15 (8), p.14427-14441

2014

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A Composite Lactide-Mineral 3D-Printed Scaffold for Bone Repair and Regeneration

Frontiers in cell and developmental biology, 2021-07, Vol.9, p.654518-654518

2021

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Senolytic Combination Treatment Is More Potent Than Single Drugs in Reducing Inflammatory and Senescence Burden in Cells from Painful Degenerating IVDs

Biomolecules (Basel, Switzerland), 2023-08, Vol.13 (8), p.1257

2023

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The Tyrosine Sulfate-rich Domains of the LRR Proteins Fibromodulin and Osteoadherin Bind Motifs of Basic Clusters in a Variety of Heparin-binding Proteins, Including Bioactive Factors

The Journal of biological chemistry, 2009-10, Vol.284 (42), p.28543-28553

2009

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Low-dose zoledronate for the treatment of bone metastasis secondary to prostate cancer

Cancer cell international, 2019-02, Vol.19 (1), p.28-28, Article 28

2019

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Neoepitope fragments as biomarkers for different phenotypes of intervertebral disc degeneration

JOR-spine, 2022-09, Vol.5 (3), p.e1215-n/a

2022

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Senotherapeutic drugs for human intervertebral disc degeneration and low back pain

3D-Printed ABS and PLA Scaffolds for Cartilage and Nucleus Pulposus Tissue Regeneration

Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain

Inflammatory Mediators in Intervertebral Disk Degeneration and Discogenic Pain

Three-Dimensional Printed Polylactic Acid Scaffolds Promote Bone-like Matrix Deposition in Vitro

Single-Cell RNA-Seq Analysis of Cells from Degenerating and Non-Degenerating Intervertebral Discs from the Same Individual Reveals New Biomarkers for Intervertebral Disc Degeneration

Automated biofabrication of anisotropic dense fibrin gels accelerate osteoblastic differentiation of seeded mesenchymal stem cells

Physiological loading can restore the proteoglycan content in a model of early IVD degeneration

Toll-like receptor 2 induced senescence in intervertebral disc cells of patients with back pain can be attenuated by o-vanillin

DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

Uncovering the secretome of mesenchymal stromal cells exposed to healthy, traumatic, and degenerative intervertebral discs: a proteomic analysis

DNA Methylation of SPARC and Chronic Low Back Pain

Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro

o-Vanillin Modulates Cell Phenotype and Extracellular Vesicles of Human Mesenchymal Stem Cells and Intervertebral Disc Cells

Development of an Organ Culture System for Long-Term Survival of the Intact Human Intervertebral Disc

The C-terminal Peptide of Chondroadherin Modulates Cellular Activity by Selectively Binding to Heparan Sulfate Chains

Organ culture bioreactors--platforms to study human intervertebral disc degeneration and regenerative therapy

The Inflammatory Milieu of the Degenerate Disc: Is Mesenchymal Stem Cell-based Therapy for Intervertebral Disc Repair a Feasible Approach?

Optimizing Design Parameters of PLA 3D-Printed Scaffolds for Bone Defect Repair

Low-frequency high-magnitude mechanical strain of articular chondrocytes activates p38 MAPK and induces phenotypic changes associated with osteoarthritis and pain

A Composite Lactide-Mineral 3D-Printed Scaffold for Bone Repair and Regeneration

Senolytic Combination Treatment Is More Potent Than Single Drugs in Reducing Inflammatory and Senescence Burden in Cells from Painful Degenerating IVDs

The Tyrosine Sulfate-rich Domains of the LRR Proteins Fibromodulin and Osteoadherin Bind Motifs of Basic Clusters in a Variety of Heparin-binding Proteins, Including Bioactive Factors

Low-dose zoledronate for the treatment of bone metastasis secondary to prostate cancer

Neoepitope fragments as biomarkers for different phenotypes of intervertebral disc degeneration

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