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The Future of Peptide-based Drugs

Chemical biology & drug design, 2013-01, Vol.81 (1), p.136-147

2013

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Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule

Nature structural & molecular biology, 2019-06, Vol.26 (6), p.501-509

2019

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Peptidic macrocyclization via palladium-catalyzed chemoselective indole C-2 arylation

Chemical communications (Cambridge, England), 2012-01, Vol.48 (95), p.11644-11646

2012

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Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing

Journal of the American Chemical Society, 2018-05, Vol.140 (21), p.6596-6603

2018

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Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules

Journal of medicinal chemistry, 2017-03, Vol.60 (5), p.1665-1672

2017

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Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (49), p.17504-17509

2014

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Fmoc-Based Synthesis of Disulfide-Rich Cyclic Peptides

Journal of organic chemistry, 2014-06, Vol.79 (12), p.5538-5544

2014

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On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

Nature chemical biology, 2011-09, Vol.7 (11), p.810-817

2011

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Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable

Angewandte Chemie International Edition, 2014-11, Vol.53 (45), p.12059-12063

International ed. in English, 2014

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Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

PLoS biology, 2017-03, Vol.15 (3), p.e2001882

2017

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Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products

Journal of medicinal chemistry, 2015-06, Vol.58 (11), p.4581-4589

2015

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Exploring experimental and computational markers of cyclic peptides: Charting islands of permeability

European journal of medicinal chemistry, 2015-06, Vol.97, p.202-213

2015

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Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy

Journal of medicinal chemistry, 2009-12, Vol.52 (24), p.7946-7949

2009

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Discovery of Potent and Orally Bioavailable Macrocyclic Peptide–Peptoid Hybrid CXCR7 Modulators

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9653-9663

2017

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Use of 3D Properties to Characterize Beyond Rule-of-5 Property Space for Passive Permeation

Journal of chemical information and modeling, 2012-04, Vol.52 (4), p.882-890

2012

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Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides

Organic letters, 2015-06, Vol.17 (12), p.2928-2931

2015

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Medicinal chemistry design principles for liver targeting through OATP transporters

Current topics in medicinal chemistry, 2013-04, Vol.13 (7), p.857-866

2013

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Functionalization of Aromatic Amino Acids via Direct C−H Activation: Generation of Versatile Building Blocks for Accessing Novel Peptide Space

Organic letters, 2010-09, Vol.12 (17), p.3870-3873

2010

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Translational Diffusion of Cyclic Peptides Measured Using Pulsed-Field Gradient NMR

The journal of physical chemistry. B, 2014-09, Vol.118 (38), p.11129-11136

2014

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Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance()

MedChemComm, 2012-10, Vol.3 (10), p.1282-1289

2012

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Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

PLoS biology, 2018-04, Vol.16 (4), p.e1002628-e1002628

2018

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Discovery of a Series of 6,7-Dimethoxy-4-pyrrolidylquinazoline PDE10A Inhibitors

Journal of medicinal chemistry, 2007-01, Vol.50 (2), p.182-185

2007

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Design and Synthesis of Diazatricyclodecane Agonists of the G‑Protein-Coupled Receptor 119

Journal of medicinal chemistry, 2013-01, Vol.56 (1), p.301-319

2013

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Phosphodiesterases and Their Inhibitors

1, 2014

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Permeability of Cyclic Peptide Macrocycles and Cyclotides and Their Potential as Therapeutics

ACS medicinal chemistry letters, 2019-07, Vol.10 (7), p.1026-1032

2019

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The Future of Peptide-based Drugs

Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule

Peptidic macrocyclization via palladium-catalyzed chemoselective indole C-2 arylation

Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing

Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules

Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients

Fmoc-Based Synthesis of Disulfide-Rich Cyclic Peptides

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products

Exploring experimental and computational markers of cyclic peptides: Charting islands of permeability

Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy

Discovery of Potent and Orally Bioavailable Macrocyclic Peptide–Peptoid Hybrid CXCR7 Modulators

Use of 3D Properties to Characterize Beyond Rule-of-5 Property Space for Passive Permeation

Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides

Medicinal chemistry design principles for liver targeting through OATP transporters

Functionalization of Aromatic Amino Acids via Direct C−H Activation: Generation of Versatile Building Blocks for Accessing Novel Peptide Space

Translational Diffusion of Cyclic Peptides Measured Using Pulsed-Field Gradient NMR

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance()

Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

Discovery of a Series of 6,7-Dimethoxy-4-pyrrolidylquinazoline PDE10A Inhibitors

Design and Synthesis of Diazatricyclodecane Agonists of the G‑Protein-Coupled Receptor 119

Phosphodiesterases and Their Inhibitors

Permeability of Cyclic Peptide Macrocycles and Cyclotides and Their Potential as Therapeutics

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