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Mechanism of local anesthetic drug action on voltage-gated sodium channels

Current pharmaceutical design, 2005-08, Vol.11 (21), p.2671-2686

2005

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Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families

Diabetologia, 1997-02, Vol.40 (2), p.217-224

1997

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KcsA Crystal Structure as Framework for a Molecular Model of the Na+ Channel Pore

Biochemistry (Easton), 2000-07, Vol.39 (28), p.8161-8170

2000

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Isoform-dependent interaction of voltage-gated sodium channels with protons

The Journal of physiology, 2006-10, Vol.576 (2), p.493-501

2006

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A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

Biophysical journal, 1994, Vol.66 (1), p.1-13

1994

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Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block

The Journal of physiology, 2002-08, Vol.543 (1), p.71-84

2002

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The tetrodotoxin binding site is within the outer vestibule of the sodium channel

Marine Drugs, 2010-02, Vol.8 (2), p.219-234

2010

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mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains

The Journal of general physiology, 2000-11, Vol.116 (5), p.679-690

2000

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Modeling of the Outer Vestibule and Selectivity Filter of the L-Type Ca2+ Channel

Biochemistry (Easton), 2001-06, Vol.40 (23), p.6786-6794

2001

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Differences in Saxitoxin and Tetrodotoxin Binding Revealed by Mutagenesis of the Na + Channel Outer Vestibule

Biophysical journal, 1998-12, Vol.75 (6), p.2647-2657

1998

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Molecular Model of Anticonvulsant Drug Binding to the Voltage-Gated Sodium Channel Inner Pore

Molecular pharmacology, 2010-10, Vol.78 (4), p.631-638

2010

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Predominant Interactions between μ-Conotoxin Arg-13 and the Skeletal Muscle Na+ Channel Localized by Mutant Cycle Analysis

Biochemistry (Easton), 1998-03, Vol.37 (13), p.4407-4419

1998

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Molecular Modeling of Local Anesthetic Drug Binding by Voltage-Gated Sodium Channels

Molecular pharmacology, 2005-12, Vol.68 (6), p.1611-1622

2005

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A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule

Biophysical journal, 1995-11, Vol.69 (5), p.1657-1665

1995

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Mutational Analysis of Predicted Interactions between the Catalytic and P Domains of Prohormone Convertase 3 (PC3/PC1)

Proceedings of the National Academy of Sciences - PNAS, 2003-05, Vol.100 (10), p.5622-5627

2003

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A model of scorpion toxin binding to voltage-gated K+ channels

The Journal of membrane biology, 1997-08, Vol.158 (3), p.187-196

1997

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Lysine-Phosphatidylcholine Adducts in Kringle V Impart Unique Immunological and Potential Pro-inflammatory Properties to Human Apolipoprotein(a)

The Journal of biological chemistry, 2003-12, Vol.278 (52), p.52841-52847

2003

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A Model for the Structure of the P Domains in the Subtilisin-Like Prohormone Convertases

Proceedings of the National Academy of Sciences - PNAS, 1998-06, Vol.95 (13), p.7310-7315

1998

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A Structural Motif for the Voltage-Gated Potassium Channel Pore

Proceedings of the National Academy of Sciences - PNAS, 1995-09, Vol.92 (20), p.9215-9219

1995

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Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine

The Journal of biological chemistry, 2004-08, Vol.279 (35), p.36788-36794

2004

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Sodium Channel Molecular Conformations and Antiarrhythmic Drug Affinity

Trends in cardiovascular medicine, 2010, Vol.20 (1), p.16-21

2010

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Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin

The Journal of general physiology, 2002-01, Vol.119 (1), p.45-54

2002

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Proteolytic Processing Mechanisms in the Biosynthesis of Neuroendocrine Peptides: The Subtilisin-like Proprotein Convertases

Frontiers in neuroendocrinology, 1995-10, Vol.16 (4), p.322-361

1995

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Regulatory Roles of the P Domain of the Subtilisin-like Prohormone Convertases

The Journal of biological chemistry, 1998-05, Vol.273 (18), p.11107-11114

1998

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N.m.r. and conformational analysis of some 2,3-disubstituted methyl α- l-rhamnopyranosides

Carbohydrate research, 1991-12, Vol.221 (1), p.145-168

1991

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Mechanism of local anesthetic drug action on voltage-gated sodium channels

Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families

KcsA Crystal Structure as Framework for a Molecular Model of the Na+ Channel Pore

Isoform-dependent interaction of voltage-gated sodium channels with protons

A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block

The tetrodotoxin binding site is within the outer vestibule of the sodium channel

mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains

Modeling of the Outer Vestibule and Selectivity Filter of the L-Type Ca2+ Channel

Differences in Saxitoxin and Tetrodotoxin Binding Revealed by Mutagenesis of the Na + Channel Outer Vestibule

Molecular Model of Anticonvulsant Drug Binding to the Voltage-Gated Sodium Channel Inner Pore

Predominant Interactions between μ-Conotoxin Arg-13 and the Skeletal Muscle Na+ Channel Localized by Mutant Cycle Analysis

Molecular Modeling of Local Anesthetic Drug Binding by Voltage-Gated Sodium Channels

A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule

Mutational Analysis of Predicted Interactions between the Catalytic and P Domains of Prohormone Convertase 3 (PC3/PC1)

A model of scorpion toxin binding to voltage-gated K+ channels

Lysine-Phosphatidylcholine Adducts in Kringle V Impart Unique Immunological and Potential Pro-inflammatory Properties to Human Apolipoprotein(a)

A Model for the Structure of the P Domains in the Subtilisin-Like Prohormone Convertases

A Structural Motif for the Voltage-Gated Potassium Channel Pore

Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine

Sodium Channel Molecular Conformations and Antiarrhythmic Drug Affinity

Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin

Proteolytic Processing Mechanisms in the Biosynthesis of Neuroendocrine Peptides: The Subtilisin-like Proprotein Convertases

Regulatory Roles of the P Domain of the Subtilisin-like Prohormone Convertases

N.m.r. and conformational analysis of some 2,3-disubstituted methyl α- l-rhamnopyranosides

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