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Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions

Advanced drug delivery reviews, 2016-06, Vol.101, p.34-41

Lipinski, Christopher A.

2016

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Advanced drug delivery reviews, 2012-12, Vol.64, p.4-17

2012

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Lead- and drug-like compounds: the rule-of-five revolution

Drug discovery today. Technologies, 2004-12, Vol.1 (4), p.337-341

Lipinski, Christopher A.

2004

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Navigating chemical space for biology and medicine

Nature, 2004-12, Vol.432 (7019), p.855-861

2004

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Phenotypic screening of low molecular weight compounds is rich ground for repurposed, on-target drugs

Frontiers in pharmacology, 2022-08, Vol.13, p.917968-917968

2022

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High throughput in vivo phenotypic screening for drug repurposing: Discovery of MLR-1023 a novel insulin sensitizer and novel Lyn kinase activator with clinical proof of concept

Bioorganic & medicinal chemistry, 2020-05, Vol.28 (9), p.115425-115425, Article 115425

2020

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The rule of five should not impede anti-parasitic drug development

International journal for parasitology -- drugs and drug resistance, 2017-08, Vol.7 (2), p.248-249

2017

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Advanced drug delivery reviews, 2001-03, Vol.46 (1), p.3-26

2001

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Thermodynamic Proxies to Compensate for Biases in Drug Discovery Methods

Pharmaceutical research, 2016-01, Vol.33 (1), p.194-205

2016

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Parallel worlds of public and commercial bioactive chemistry data

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2068-2076

2015

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Badapple: promiscuity patterns from noisy evidence

Journal of cheminformatics, 2016-05, Vol.8 (1), p.29-29, Article 29

2016

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Targeting Pyk2 for therapeutic intervention

Expert opinion on therapeutic targets, 2010-01, Vol.14 (1), p.95-108

2010

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Advanced drug delivery reviews, 1997-01, Vol.23 (1), p.3-25

1997

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Computational Prediction and Validation of an Expert’s Evaluation of Chemical Probes

Journal of chemical information and modeling, 2014-10, Vol.54 (10), p.2996-3004

2014

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Emergency Department Rotational Patient Assignment

Annals of emergency medicine, 2016-02, Vol.67 (2), p.206-215

2016

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Emergency Department Rapid Medical Assessment: Overall Effect and Mechanistic Considerations

The Journal of emergency medicine, 2015-05, Vol.48 (5), p.620-627

2015

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Serum Lactate and Mortality in Emergency Department Patients with Cancer

The western journal of emergency medicine, 2018-09, Vol.19 (5), p.827-833

2018

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Chris Lipinski discusses life and chemistry after the Rule of Five

Drug discovery today, 2003, Vol.8 (1), p.12-16

Owens, Joanna

2003

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Topographic and sea level controls on oolite-microbialite-coralgal reef sequences: The terminal carbonate complex of southeast Spain

AAPG bulletin, 2013-11, Vol.97 (11), p.1997-2034

2013

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Physician in Triage Versus Rotational Patient Assignment

The Journal of emergency medicine, 2016-05, Vol.50 (5), p.784-790

2016

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A crowdsourcing evaluation of the NIH chemical probes

Nature chemical biology, 2009-07, Vol.5 (7), p.441-447

2009

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Reservoir analog model for oolite-microbialite sequences, Miocene terminal carbonate complex, Spain

AAPG bulletin, 2013-11, Vol.97 (11), p.2035-2057

2013

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The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes

The Journal of pharmacology and experimental therapeutics, 2012-07, Vol.342 (1), p.23-32

2012

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MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo

The Journal of pharmacology and experimental therapeutics, 2012-07, Vol.342 (1), p.15-22

2012

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Small molecules with antiviral activity against the Ebola virus [version 1; peer review: 2 approved]

F1000 research, 2015, Vol.4, p.38-38

2015

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Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Lead- and drug-like compounds: the rule-of-five revolution

Navigating chemical space for biology and medicine

Phenotypic screening of low molecular weight compounds is rich ground for repurposed, on-target drugs

High throughput in vivo phenotypic screening for drug repurposing: Discovery of MLR-1023 a novel insulin sensitizer and novel Lyn kinase activator with clinical proof of concept

The rule of five should not impede anti-parasitic drug development

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Thermodynamic Proxies to Compensate for Biases in Drug Discovery Methods

Parallel worlds of public and commercial bioactive chemistry data

Badapple: promiscuity patterns from noisy evidence

Targeting Pyk2 for therapeutic intervention

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Computational Prediction and Validation of an Expert’s Evaluation of Chemical Probes

Emergency Department Rotational Patient Assignment

Emergency Department Rapid Medical Assessment: Overall Effect and Mechanistic Considerations

Serum Lactate and Mortality in Emergency Department Patients with Cancer

Chris Lipinski discusses life and chemistry after the Rule of Five

Topographic and sea level controls on oolite-microbialite-coralgal reef sequences: The terminal carbonate complex of southeast Spain

Physician in Triage Versus Rotational Patient Assignment

A crowdsourcing evaluation of the NIH chemical probes

Reservoir analog model for oolite-microbialite sequences, Miocene terminal carbonate complex, Spain

The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes

MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo

Small molecules with antiviral activity against the Ebola virus [version 1; peer review: 2 approved]

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