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Synthesis and Antiviral Activity of a Series of 2'- C -Methyl-4'-thionucleoside Monophosphate Prodrugs

Molecules (Basel, Switzerland), 2020-11, Vol.25 (21), p.5165

2020

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GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity

Molecular pharmacology, 2016-12, Vol.90 (6), p.689-702

2016

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Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors

Nature communications, 2019-01, Vol.10 (1), p.321-321, Article 321

2019

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Context-Dependent GluN2B-Selective Inhibitors of NMDA Receptor Function Are Neuroprotective with Minimal Side Effects

Neuron (Cambridge, Mass.), 2015-03, Vol.85 (6), p.1305-1318

2015

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Thematic Review Series: Sphingolipids. Biodiversity of sphingoid bases (“sphingosines”) and related amino alcohols

Journal of lipid research, 2008-08, Vol.49 (8), p.1621-1639

2008

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Characterization of a CXCR4 antagonist TIQ-15 with dual tropic HIV entry inhibition properties

PLoS pathogens, 2024-08, Vol.20 (8), p.e1012448

2024

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Development of a unique small molecule modulator of CXCR4

PloS one, 2012-04, Vol.7 (4), p.e34038

2012

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Reduction Sensitive Lipid Conjugates of Tenofovir: Synthesis, Stability, and Antiviral Activity

Journal of medicinal chemistry, 2016-08, Vol.59 (15), p.7097-7110

2016

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Recent advances in the development of HBV capsid assembly modulators

Current opinion in chemical biology, 2019-06, Vol.50, p.73-79

2019

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Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis

European journal of medicinal chemistry, 2015-03, Vol.92, p.693-699

2015

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A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors

Nature communications, 2010-10, Vol.1 (7), p.1-8, Article 90

2010

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CCR5 receptor antagonists in preclinical to phase II clinical development for treatment of HIV

Expert opinion on investigational drugs, 2016-12, Vol.25 (12), p.1377-1392

2016

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An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups

eLife, 2018-05, Vol.7

2018

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Discovery of Small Molecule CXCR4 Antagonists

Journal of medicinal chemistry, 2007-11, Vol.50 (23), p.5655-5664

2007

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Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators

Molecular pharmacology, 2011-11, Vol.80 (5), p.782-795

2011

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Expanding the toolbox of metabolically stable lipid prodrug strategies

Frontiers in pharmacology, 2023-01, Vol.13, p.1083284-1083284

2023

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Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents

Bioorganic & medicinal chemistry, 2004-07, Vol.12 (14), p.3871-3883

2004

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Quinazolin-4-one Derivatives: A Novel Class of Noncompetitive NR2C/D Subunit-Selective N-Methyl-d-aspartate Receptor Antagonists

Journal of medicinal chemistry, 2010-08, Vol.53 (15), p.5476-5490

2010

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Structural analysis of CXCR4 – Antagonist interactions using saturation-transfer double-difference NMR

Biochemical and biophysical research communications, 2015-10, Vol.466 (1), p.28-32

2015

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Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6627-6631

2009

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Polyoxometalate HIV-1 Protease Inhibitors. A New Mode of Protease Inhibition

Journal of the American Chemical Society, 2001-02, Vol.123 (5), p.886-897

2001

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Chloride is an Agonist of Group II and III Metabotropic Glutamate Receptors

Molecular pharmacology, 2015-09, Vol.88 (3), p.450-459

2015

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Journal of Medicinal Chemistry/ACS Medicinal Chemistry Letters/Division of Medicinal Chemistry Joint Portoghese Lectureship Awards: CALL FOR NOMINATIONS

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.1610-1611

2022

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EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism

Anti-cancer drugs, 2005-03, Vol.16 (3), p.263-275

2005

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Discovery and Development of the Anti-Human Immunodeficiency Virus Drug, Emtricitabine (Emtriva, FTC)

Accounts of chemical research, 2016-10, Vol.49 (10), p.2091-2098

2016

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Synthesis and Antiviral Activity of a Series of 2'- C -Methyl-4'-thionucleoside Monophosphate Prodrugs

GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity

Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors

Context-Dependent GluN2B-Selective Inhibitors of NMDA Receptor Function Are Neuroprotective with Minimal Side Effects

Thematic Review Series: Sphingolipids. Biodiversity of sphingoid bases (“sphingosines”) and related amino alcohols

Characterization of a CXCR4 antagonist TIQ-15 with dual tropic HIV entry inhibition properties

Development of a unique small molecule modulator of CXCR4

Reduction Sensitive Lipid Conjugates of Tenofovir: Synthesis, Stability, and Antiviral Activity

Recent advances in the development of HBV capsid assembly modulators

Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis

A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors

CCR5 receptor antagonists in preclinical to phase II clinical development for treatment of HIV

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups

Discovery of Small Molecule CXCR4 Antagonists

Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators

Expanding the toolbox of metabolically stable lipid prodrug strategies

Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents

Quinazolin-4-one Derivatives: A Novel Class of Noncompetitive NR2C/D Subunit-Selective N-Methyl-d-aspartate Receptor Antagonists

Structural analysis of CXCR4 – Antagonist interactions using saturation-transfer double-difference NMR

Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism

Polyoxometalate HIV-1 Protease Inhibitors. A New Mode of Protease Inhibition

Chloride is an Agonist of Group II and III Metabotropic Glutamate Receptors

Journal of Medicinal Chemistry/ACS Medicinal Chemistry Letters/Division of Medicinal Chemistry Joint Portoghese Lectureship Awards: CALL FOR NOMINATIONS

EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism

Discovery and Development of the Anti-Human Immunodeficiency Virus Drug, Emtricitabine (Emtriva, FTC)

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