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An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

Nature chemical biology, 2017-04, Vol.13 (4), p.381-388

2017

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Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain

Nature, 2003-11, Vol.426 (6965), p.465-469

2003

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Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β

Nature communications, 2023-09, Vol.14 (1), p.5497-5497, Article 5497

2023

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Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase

Journal of medicinal chemistry, 2017-01, Vol.60 (1), p.415-427

2017

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Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED

PloS one, 2017-01, Vol.12 (1), p.e0169855-e0169855

2017

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The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition

EMBO reports, 2005-12, Vol.6 (12), p.1149-1155

2005

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Cyclic Green Fluorescent Protein Produced in Vivo Using an Artificially Split PI-PfuI Intein from Pyrococcus furiosus

The Journal of biological chemistry, 2001-05, Vol.276 (19), p.16548-16554

2001

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Structure of the Complex between HER2 and an Antibody Paratope Formed by Side Chains from Tryptophan and Serine

Journal of molecular biology, 2010-09, Vol.402 (1), p.217-229

2010

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The C-terminal region of Ge-1 presents conserved structural features required for P-body localization

RNA (Cambridge), 2008-10, Vol.14 (10), p.1991-1998

2008

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RNAi: finding the elusive endonuclease

RNA (Cambridge), 2004-11, Vol.10 (11), p.1675-1679

2004

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High-Confidence Protein–Ligand Complex Modeling by NMR-Guided Docking Enables Early Hit Optimization

Journal of the American Chemical Society, 2017-12, Vol.139 (49), p.17824-17833

2017

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The Disordered MAX N-terminus Modulates DNA Binding of the Transcription Factor MYC:MAX

Journal of molecular biology, 2022-11, Vol.434 (22), p.167833-167833, Article 167833

2022

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Hydrogen bond formation may enhance RDC‐based discrimination of enantiomers

Magnetic resonance in chemistry, 2024-09, Vol.62 (9), p.639-647

2024

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Nucleic acid 3′-end recognition by the Argonaute2 PAZ domain

Nature structural & molecular biology, 2004-06, Vol.11 (6), p.576-577

2004

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JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors

Journal of medicinal chemistry, 2022-12, Vol.65 (24), p.16173-16203

2022

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Efficient Screening of Target-Specific Selected Compounds in Mixtures by 19 F NMR Binding Assay with Predicted 19 F NMR Chemical Shifts

ChemMedChem, 2022-07, Vol.17 (13), p.e202200163-e202200163

2022

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Efficient Screening of Target‐Specific Selected Compounds in Mixtures by 19F NMR Binding Assay with Predicted 19F NMR Chemical Shifts

ChemMedChem, 2022-07, Vol.17 (13), p.n/a

2022

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Intrinsically Disordered Regions in the Transcription Factor MYC:MAX Modulate DNA Binding via Intramolecular Interactions

Biochemistry (Easton), 2024-01, Vol.63 (4), p.498-511

2024

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Facilitating unambiguous NMR assignments and enabling higher probe density through selective labeling of all methyl containing amino acids

Journal of biomolecular NMR, 2016-05, Vol.65 (1), p.15-27

2016

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Fast and Efficient Fragment-Based Lead Generation by Fully Automated Processing and Analysis of Ligand-Observed NMR Binding Data

Journal of medicinal chemistry, 2016-04, Vol.59 (7), p.3303-3310

2016

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Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy

Journal of medicinal chemistry, 2017-03, Vol.60 (6), p.2215-2226

2017

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Quantitative and functional characterisation of extracellular vesicles after passive loading with hydrophobic or cholesterol-tagged small molecules

Journal of controlled release, 2023-09, Vol.361, p.694-716

2023

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Inside Cover: Comprehensive and High‐Throughput Exploration of Chemical Space Using Broadband 19 F NMR‐Based Screening (Angew. Chem. Int. Ed. 35/2020)

Angewandte Chemie International Edition, 2020-08, Vol.59 (35), p.14698-14698

2020

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An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain

Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β

Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase

Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED

The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition

Inhibition of prenylated KRAS in a lipid environment

Cyclic Green Fluorescent Protein Produced in Vivo Using an Artificially Split PI-PfuI Intein from Pyrococcus furiosus

Structure of the Complex between HER2 and an Antibody Paratope Formed by Side Chains from Tryptophan and Serine

The C-terminal region of Ge-1 presents conserved structural features required for P-body localization

RNAi: finding the elusive endonuclease

High-Confidence Protein–Ligand Complex Modeling by NMR-Guided Docking Enables Early Hit Optimization

The Disordered MAX N-terminus Modulates DNA Binding of the Transcription Factor MYC:MAX

Hydrogen bond formation may enhance RDC‐based discrimination of enantiomers

Nucleic acid 3′-end recognition by the Argonaute2 PAZ domain

JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors

Efficient Screening of Target-Specific Selected Compounds in Mixtures by 19 F NMR Binding Assay with Predicted 19 F NMR Chemical Shifts

Efficient Screening of Target‐Specific Selected Compounds in Mixtures by 19F NMR Binding Assay with Predicted 19F NMR Chemical Shifts

Intrinsically Disordered Regions in the Transcription Factor MYC:MAX Modulate DNA Binding via Intramolecular Interactions

Facilitating unambiguous NMR assignments and enabling higher probe density through selective labeling of all methyl containing amino acids

Fast and Efficient Fragment-Based Lead Generation by Fully Automated Processing and Analysis of Ligand-Observed NMR Binding Data

Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy

Quantitative and functional characterisation of extracellular vesicles after passive loading with hydrophobic or cholesterol-tagged small molecules

Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies

Inside Cover: Comprehensive and High‐Throughput Exploration of Chemical Space Using Broadband 19 F NMR‐Based Screening (Angew. Chem. Int. Ed. 35/2020)

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