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The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: a perspective of the pharmaceutical research and manufacturers of America

Drug metabolism and disposition, 2009-07, Vol.37 (7), p.1355-1370

2009

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Validation of LC-MS/MS methods for determination of remdesivir and its metabolites GS-441524 and GS-704277 in acidified human plasma and their application in COVID-19 related clinical studies

Analytical biochemistry, 2021-03, Vol.617, p.114118-114118, Article 114118

2021

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Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry

Journal of lipid research, 2004-04, Vol.45 (4), p.757-763

2004

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Quantitation of intracellular triphosphate metabolites of antiretroviral agents in peripheral blood mononuclear cells (PBMCs) and corresponding cell count determinations: review of current methods and challenges

Expert opinion on drug metabolism & toxicology, 2018-08, Vol.14 (8), p.781-802

2018

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Enzymatic formation of prostamide F2α from anandamide involves a newly identified intermediate metabolite, prostamide H2

Journal of lipid research, 2005-12, Vol.46 (12), p.2745-2751

2005

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Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotenic acid in humans

Drug metabolism and disposition, 2003-04, Vol.31 (4), p.476-481

2003

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Disposition and Biotransformation of the Acetylenic Retinoid Tazarotene in Humans

Journal of pharmaceutical sciences, 2005-10, Vol.94 (10), p.2246-2255

2005

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Ophthalmic drug delivery considerations at the cellular level: drug-metabolising enzymes and transporters

Expert opinion on drug delivery, 2005-09, Vol.2 (5), p.891-908

2005

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Drug-Drug Interaction Studies Between Hepatitis C Virus Antivirals Sofosbuvir/Velpatasvir and Boosted and Unboosted Human Immunodeficiency Virus Antiretroviral Regimens in Healthy Volunteers

Clinical infectious diseases, 2018-08, Vol.67 (6), p.934-940

2018

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Plasma Protein Binding Determination for Unstable Ester Prodrugs: Remdesivir and Tenofovir Alafenamide

Journal of pharmaceutical sciences, 2023-12, Vol.112 (12), p.3224-3232

2023

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The determination of human peripheral blood mononuclear cell counts using a genomic DNA standard and application in tenofovir diphosphate quantitation

Analytical biochemistry, 2019-11, Vol.585, p.113399-113399, Article 113399

2019

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The determination of Sulfobutylether β-Cyclodextrin Sodium (SBECD) by LC-MS/MS and its application in remdesivir pharmacokinetics study for pediatric patients

Journal of pharmaceutical and biomedical analysis, 2022-04, Vol.212, p.114646-114646, Article 114646

2022

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Active site dynamics of xylene hydroxylation by cytochrome P-450 as revealed by kinetic deuterium isotope effects

Journal of the American Chemical Society, 1993-10, Vol.115 (21), p.9363-9370

1993

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An LC-MS/MS method for determination of tenofovir (TFV) in human plasma following tenofovir alafenamide (TAF) administration: Development, validation, cross-validation, and use of formic acid as plasma TFV stabilizer

Analytical biochemistry, 2020-03, Vol.593, p.113611, Article 113611

2020

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Cytochrome P450 3A Expression and Activity in the Rabbit Lacrimal Gland: Glucocorticoid Modulation and the Impact on Androgen Metabolism

Investigative ophthalmology & visual science, 2005-12, Vol.46 (12), p.4697-4706

2005

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Pharmacokinetics and Safety of Velpatasvir and Sofosbuvir/Velpatasvir in Subjects with Hepatic Impairment

Clinical pharmacokinetics, 2018-11, Vol.57 (11), p.1449-1457

2018

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Deuterium isotope effects on toluene metabolism. Product release as a rate-limiting step in cytochrome P-450 catalysis

Biochemical and biophysical research communications, 1989-04, Vol.160 (2), p.844-849

1989

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Active site dynamics of toluene hydroxylation by cytochrome P-450

Journal of organic chemistry, 1990-06, Vol.55 (13), p.3992-3997

1990

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Idiosyncratic reactions and metabolism of sulfur-containing drugs

Expert opinion on drug metabolism & toxicology, 2012-04, Vol.8 (4), p.467-485

2012

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Enzymatic formation of prostamide F2alpha from anandamide involves a newly identified intermediate metabolite, prostamide H2

Journal of lipid research, 2005-12, Vol.46 (12), p.2745

2005

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Enzymatic formation of prostamide F[subscript 2[alpha]] from anandamide involves a newly identified intermediate metabolite, prostamide H

Journal of lipid research, 2005, Vol.46 (12), p.2745-2751

2005

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Synthesis and studies of 5-mercapto-substituted oligo- and polynucleotides as anti-viral agents

Ling, Kah-Hiing John

1992

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Structure-activity relationships and mode of action of 5-mercapto-substituted oligo- and polynucleotides as antitemplates inhibiting replication of human immunodeficiency virus type 1

Antimicrobial Agents and Chemotherapy, 1992-01, Vol.36 (1), p.108-114

1992

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The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: a perspective of the pharmaceutical research and manufacturers of America

Validation of LC-MS/MS methods for determination of remdesivir and its metabolites GS-441524 and GS-704277 in acidified human plasma and their application in COVID-19 related clinical studies

Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry

Quantitation of intracellular triphosphate metabolites of antiretroviral agents in peripheral blood mononuclear cells (PBMCs) and corresponding cell count determinations: review of current methods and challenges

Enzymatic formation of prostamide F2α from anandamide involves a newly identified intermediate metabolite, prostamide H2

Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotenic acid in humans

Disposition and Biotransformation of the Acetylenic Retinoid Tazarotene in Humans

Ophthalmic drug delivery considerations at the cellular level: drug-metabolising enzymes and transporters

Drug-Drug Interaction Studies Between Hepatitis C Virus Antivirals Sofosbuvir/Velpatasvir and Boosted and Unboosted Human Immunodeficiency Virus Antiretroviral Regimens in Healthy Volunteers

Plasma Protein Binding Determination for Unstable Ester Prodrugs: Remdesivir and Tenofovir Alafenamide

The determination of human peripheral blood mononuclear cell counts using a genomic DNA standard and application in tenofovir diphosphate quantitation

The determination of Sulfobutylether β-Cyclodextrin Sodium (SBECD) by LC-MS/MS and its application in remdesivir pharmacokinetics study for pediatric patients

Active site dynamics of xylene hydroxylation by cytochrome P-450 as revealed by kinetic deuterium isotope effects

An LC-MS/MS method for determination of tenofovir (TFV) in human plasma following tenofovir alafenamide (TAF) administration: Development, validation, cross-validation, and use of formic acid as plasma TFV stabilizer

Cytochrome P450 3A Expression and Activity in the Rabbit Lacrimal Gland: Glucocorticoid Modulation and the Impact on Androgen Metabolism

Pharmacokinetics and Safety of Velpatasvir and Sofosbuvir/Velpatasvir in Subjects with Hepatic Impairment

Deuterium isotope effects on toluene metabolism. Product release as a rate-limiting step in cytochrome P-450 catalysis

Active site dynamics of toluene hydroxylation by cytochrome P-450

Idiosyncratic reactions and metabolism of sulfur-containing drugs

Enzymatic formation of prostamide F2alpha from anandamide involves a newly identified intermediate metabolite, prostamide H2

Enzymatic formation of prostamide F[subscript 2[alpha]] from anandamide involves a newly identified intermediate metabolite, prostamide H

Synthesis and studies of 5-mercapto-substituted oligo- and polynucleotides as anti-viral agents

Structure-activity relationships and mode of action of 5-mercapto-substituted oligo- and polynucleotides as antitemplates inhibiting replication of human immunodeficiency virus type 1

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