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The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: a perspective of the pharmaceutical research and manufacturers of America

Drug metabolism and disposition, 2009-07, Vol.37 (7), p.1355

2009

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Validation of LC-MS/MS methods for determination of remdesivir and its metabolites GS-441524 and GS-704277 in acidified human plasma and their application in COVID-19 related clinical studies

Analytical biochemistry, 2021-03, Vol.617, p.114118-114118, Article 114118

2021

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Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry

Journal of lipid research, 2004-04, Vol.45 (4), p.757-763

2004

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Enzymatic formation of prostamide F2α from anandamide involves a newly identified intermediate metabolite, prostamide H2

Journal of lipid research, 2005-12, Vol.46 (12), p.2745-2751

2005

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Quantitation of intracellular triphosphate metabolites of antiretroviral agents in peripheral blood mononuclear cells (PBMCs) and corresponding cell count determinations: review of current methods and challenges

Expert opinion on drug metabolism & toxicology, 2018-08, Vol.14 (8), p.781-802

2018

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Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotenic acid in humans

Drug metabolism and disposition, 2003-04, Vol.31 (4), p.476

2003

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Disposition and Biotransformation of the Acetylenic Retinoid Tazarotene in Humans

Journal of pharmaceutical sciences, 2005-10, Vol.94 (10), p.2246-2255

2005

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Ophthalmic drug delivery considerations at the cellular level: drug-metabolising enzymes and transporters

Expert opinion on drug delivery, 2005-09, Vol.2 (5), p.891-908

2005

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Drug-Drug Interaction Studies Between Hepatitis C Virus Antivirals Sofosbuvir/Velpatasvir and Boosted and Unboosted Human Immunodeficiency Virus Antiretroviral Regimens in Healthy Volunteers

Clinical infectious diseases, 2018-08, Vol.67 (6), p.934-940

2018

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Plasma Protein Binding Determination for Unstable Ester Prodrugs: Remdesivir and Tenofovir Alafenamide

Journal of pharmaceutical sciences, 2023-12, Vol.112 (12), p.3224-3232

2023

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The determination of human peripheral blood mononuclear cell counts using a genomic DNA standard and application in tenofovir diphosphate quantitation

Analytical biochemistry, 2019-11, Vol.585, p.113399-113399, Article 113399

2019

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Active site dynamics of xylene hydroxylation by cytochrome P-450 as revealed by kinetic deuterium isotope effects

Journal of the American Chemical Society, 1993-10, Vol.115 (21), p.9363-9370

1993

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The determination of Sulfobutylether β-Cyclodextrin Sodium (SBECD) by LC-MS/MS and its application in remdesivir pharmacokinetics study for pediatric patients

Journal of pharmaceutical and biomedical analysis, 2022-04, Vol.212, p.114646-114646, Article 114646

2022

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An LC-MS/MS method for determination of tenofovir (TFV) in human plasma following tenofovir alafenamide (TAF) administration: Development, validation, cross-validation, and use of formic acid as plasma TFV stabilizer

Analytical biochemistry, 2020-03, Vol.593, p.113611, Article 113611

2020

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Cytochrome P450 3A Expression and Activity in the Rabbit Lacrimal Gland: Glucocorticoid Modulation and the Impact on Androgen Metabolism

Investigative ophthalmology & visual science, 2005-12, Vol.46 (12), p.4697-4706

2005

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Pharmacokinetics and Safety of Velpatasvir and Sofosbuvir/Velpatasvir in Subjects with Hepatic Impairment

Clinical pharmacokinetics, 2018-11, Vol.57 (11), p.1449-1457

2018

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Deuterium isotope effects on toluene metabolism. Product release as a rate-limiting step in cytochrome P-450 catalysis

Biochemical and biophysical research communications, 1989-04, Vol.160 (2), p.844-849

1989

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Active site dynamics of toluene hydroxylation by cytochrome P-450

Journal of organic chemistry, 1990-06, Vol.55 (13), p.3992-3997

1990

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Idiosyncratic reactions and metabolism of sulfur-containing drugs

Expert opinion on drug metabolism & toxicology, 2012-04, Vol.8 (4), p.467-485

2012

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Enzymatic formation of prostamide F2alpha from anandamide involves a newly identified intermediate metabolite, prostamide H2

Journal of lipid research, 2005-12, Vol.46 (12), p.2745

2005

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Enzymatic formation of prostamide F[subscript 2[alpha]] from anandamide involves a newly identified intermediate metabolite, prostamide H

Journal of lipid research, 2005, Vol.46 (12), p.2745-2751

2005

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Synthesis and studies of 5-mercapto-substituted oligo- and polynucleotides as anti-viral agents

Ling, Kah-Hiing John

1992

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Structure-activity relationships and mode of action of 5-mercapto-substituted oligo- and polynucleotides as antitemplates inhibiting replication of human immunodeficiency virus type 1

Antimicrobial Agents and Chemotherapy, 1992-01, Vol.36 (1), p.108-114

1992

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The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: a perspective of the pharmaceutical research and manufacturers of America

Validation of LC-MS/MS methods for determination of remdesivir and its metabolites GS-441524 and GS-704277 in acidified human plasma and their application in COVID-19 related clinical studies

Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry

Enzymatic formation of prostamide F2α from anandamide involves a newly identified intermediate metabolite, prostamide H2

Quantitation of intracellular triphosphate metabolites of antiretroviral agents in peripheral blood mononuclear cells (PBMCs) and corresponding cell count determinations: review of current methods and challenges

Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotenic acid in humans

Disposition and Biotransformation of the Acetylenic Retinoid Tazarotene in Humans

Ophthalmic drug delivery considerations at the cellular level: drug-metabolising enzymes and transporters

Drug-Drug Interaction Studies Between Hepatitis C Virus Antivirals Sofosbuvir/Velpatasvir and Boosted and Unboosted Human Immunodeficiency Virus Antiretroviral Regimens in Healthy Volunteers

Plasma Protein Binding Determination for Unstable Ester Prodrugs: Remdesivir and Tenofovir Alafenamide

The determination of human peripheral blood mononuclear cell counts using a genomic DNA standard and application in tenofovir diphosphate quantitation

Active site dynamics of xylene hydroxylation by cytochrome P-450 as revealed by kinetic deuterium isotope effects

The determination of Sulfobutylether β-Cyclodextrin Sodium (SBECD) by LC-MS/MS and its application in remdesivir pharmacokinetics study for pediatric patients

An LC-MS/MS method for determination of tenofovir (TFV) in human plasma following tenofovir alafenamide (TAF) administration: Development, validation, cross-validation, and use of formic acid as plasma TFV stabilizer

Cytochrome P450 3A Expression and Activity in the Rabbit Lacrimal Gland: Glucocorticoid Modulation and the Impact on Androgen Metabolism

Pharmacokinetics and Safety of Velpatasvir and Sofosbuvir/Velpatasvir in Subjects with Hepatic Impairment

Deuterium isotope effects on toluene metabolism. Product release as a rate-limiting step in cytochrome P-450 catalysis

Active site dynamics of toluene hydroxylation by cytochrome P-450

Idiosyncratic reactions and metabolism of sulfur-containing drugs

Enzymatic formation of prostamide F2alpha from anandamide involves a newly identified intermediate metabolite, prostamide H2

Enzymatic formation of prostamide F[subscript 2[alpha]] from anandamide involves a newly identified intermediate metabolite, prostamide H

Synthesis and studies of 5-mercapto-substituted oligo- and polynucleotides as anti-viral agents

Structure-activity relationships and mode of action of 5-mercapto-substituted oligo- and polynucleotides as antitemplates inhibiting replication of human immunodeficiency virus type 1

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