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Hyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83B

Oncogene, 2014-06, Vol.33 (25), p.3298-3306

2014

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Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice

ACS chemical neuroscience, 2015-10, Vol.6 (10), p.1683-1695

2015

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Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model

Neuropsychopharmacology (New York, N.Y.), 2016-01, Vol.41 (2), p.598-610

2016

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The Akt PKB pathway: molecular target for cancer drug discovery

Oncogene, 2005-11, Vol.24 (50), p.7482-7492

2005

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A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling

Molecular pharmacology, 2013-04, Vol.83 (4), p.835-847

2013

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N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement

The Journal of pharmacology and experimental therapeutics, 2013-11, Vol.347 (2), p.438-457

2013

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Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats

Neuropharmacology, 2013-03, Vol.66, p.330-338

2013

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DARK Classics in Chemical Neuroscience: Opium, a Historical Perspective

ACS chemical neuroscience, 2018-10, Vol.9 (10), p.2503-2518

2018

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VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy

The Journal of pharmacology and experimental therapeutics, 2016-01, Vol.356 (1), p.123-136

2016

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Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1296-1303

2016

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Discovery of positive allosteric modulators of metabotropic glutamate receptor subtype 5 (mGluR5)

Current topics in medicinal chemistry, 2005-01, Vol.5 (9), p.825-846

2005

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Role for the M 1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice

ACS chemical neuroscience, 2015-10, Vol.6 (10), p.1683-1695

2015

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Efficient Synthesis of Imidazoles from Aldehydes and 1,2-Diketones Using Microwave Irradiation

Organic letters, 2004-04, Vol.6 (9), p.1453-1456

2004

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Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.761-764

2005

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General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic pyrazines

Tetrahedron letters, 2004-06, Vol.45 (25), p.4873-4876

2004

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A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

The Journal of pharmacology and experimental therapeutics, 2005-04, Vol.313 (1), p.199-206

2005

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Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions

Platelets (Edinburgh), 2019-01, Vol.30 (1), p.126-135

2019

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Metal alkoxide catalysis of catecholborane and borane reductions. Mechanistic studies

Tetrahedron letters, 1994-07, Vol.35 (29), p.5141-5144

1994

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Potentiation of M sub(1) Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model

Neuropsychopharmacology (New York, N.Y.), 2016-01, Vol.41 (2), p.598-610

2016

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The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation

Current topics in medicinal chemistry, 2005-01, Vol.5 (2), p.109-125

2005

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A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5

Molecular pharmacology, 2003-09, Vol.64 (3), p.731-740

2003

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Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members

Molecular cancer therapeutics, 2005-02, Vol.4 (2), p.271-279

2005

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A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain

The Journal of pharmacology and experimental therapeutics, 2004-05, Vol.309 (2), p.568-577

2004

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Discovery of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 5 from a Series of N-(1,3-Diphenyl-1H- pyrazol-5-yl)benzamides That Potentiate Receptor Function in Vivo

Journal of medicinal chemistry, 2004-11, Vol.47 (24), p.5825-5828

2004

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Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (4), p.905-909

2005

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Hyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83B

Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice

Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model

The Akt PKB pathway: molecular target for cancer drug discovery

A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling

N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement

Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats

DARK Classics in Chemical Neuroscience: Opium, a Historical Perspective

VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy

Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity

Discovery of positive allosteric modulators of metabotropic glutamate receptor subtype 5 (mGluR5)

Role for the M 1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice

Efficient Synthesis of Imidazoles from Aldehydes and 1,2-Diketones Using Microwave Irradiation

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic pyrazines

A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions

Metal alkoxide catalysis of catecholborane and borane reductions. Mechanistic studies

Potentiation of M sub(1) Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model

The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation

A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5

Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members

A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain

Discovery of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 5 from a Series of N-(1,3-Diphenyl-1H- pyrazol-5-yl)benzamides That Potentiate Receptor Function in Vivo

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

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