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Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites

Nature communications, 2020-08, Vol.11 (1), p.3940-12, Article 3940

2020

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Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

Nature communications, 2018-02, Vol.9 (1), p.533-14, Article 533

2018

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Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner

Nature communications, 2019-02, Vol.10 (1), p.910-910, Article 910

2019

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SAMHD1 acts at stalled replication forks to prevent interferon induction

Nature (London), 2018-05, Vol.557 (7703), p.57-61

2018

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RNase H2 degrades toxic RNA:DNA hybrids behind stalled forks to promote replication restart

The EMBO journal, 2023-12, Vol.42 (23), p.e113104-n/a

2023

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Transcription-Replication Conflicts: Orientation Matters

Cell, 2017-08, Vol.170 (4), p.603-604

2017

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Suppression of MicroRNA-Silencing Pathway by HIV-1 During Virus Replication

Science (American Association for the Advancement of Science), 2007-03, Vol.315 (5818), p.1579-1582

2007

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Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells

The EMBO journal, 2010-04, Vol.29 (8), p.1348-1362

2010

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Replication stress: from chromatin to immunity and beyond

Current opinion in genetics & development, 2021-12, Vol.71, p.136-142

2021

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Suv39H1 and HP1γ are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency

The EMBO journal, 2007-01, Vol.26 (2), p.424-435

2007

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DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling

Journal of mammary gland biology and neoplasia, 2018-10, Vol.20 (10), p.985-995

2018

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The BLM helicase is a new therapeutic target in multiple myeloma involved in replication stress survival and drug resistance

Frontiers in immunology, 2022-12, Vol.13, p.983181

2022

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Transcription/Replication Conflicts in Tumorigenesis and Their Potential Role as Novel Therapeutic Targets in Multiple Myeloma

Cancers, 2021-07, Vol.13 (15), p.3755

2021

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Analysis of DNA replication profiles in budding yeast and mammalian cells using DNA combing

Methods (San Diego, Calif.), 2012-06, Vol.57 (2), p.149-157

2012

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SAMHD1 and the innate immune response to cytosolic DNA during DNA replication

Current opinion in immunology, 2019-02, Vol.56, p.24-30

2019

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Interference Between DNA Replication and Transcription as a Cause of Genomic Instability

Current genomics, 2012-03, Vol.13 (1), p.65-73

2012

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Topoisomerase I prevents transcription-replication conflicts at transcription termination sites

Molecular & cellular oncology, 2021-01, Vol.8 (1), p.1843951-3

2021

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Toxic R-loops: Cause or consequence of replication stress?

DNA repair, 2021-11, Vol.107, p.103199, Article 103199

2021

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TDP-43 dysfunction results in R-loop accumulation and DNA replication defects

Journal of cell science, 2020-10, Vol.133 (20)

2020

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Pharmacological Characterization and Molecular Determinants of the Activation of Transient Receptor Potential V2 Channel Orthologs by 2-Aminoethoxydiphenyl Borate

Molecular pharmacology, 2007-11, Vol.72 (5), p.1258-1268

2007

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Impact of R-loops on oncogene-induced replication stress in cancer cells

Comptes rendus. Biologies, 2023-09, Vol.346 (G2), p.95-105

2023

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Hair follicle stem cell replication stress drives IFI16/STING-dependent inflammation in hidradenitis suppurativa

The Journal of clinical investigation, 2020-07, Vol.130 (7), p.3777-3790

2020

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Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma

Cancer research (Chicago, Ill.), 2022-03, Vol.82 (6), p.998-1012

2022

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MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling

Nature communications, 2024-06, Vol.15 (1), p.5423-14, Article 5423

2024

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Small-molecule inhibition of HIV pre-mRNA splicing as a novel antiretroviral therapy to overcome drug resistance

PLoS pathogens, 2007-10, Vol.3 (10), p.1530-1539

2007

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Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner

SAMHD1 acts at stalled replication forks to prevent interferon induction

RNase H2 degrades toxic RNA:DNA hybrids behind stalled forks to promote replication restart

Transcription-Replication Conflicts: Orientation Matters

Suppression of MicroRNA-Silencing Pathway by HIV-1 During Virus Replication

Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells

Replication stress: from chromatin to immunity and beyond

Suv39H1 and HP1γ are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency

DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling

The BLM helicase is a new therapeutic target in multiple myeloma involved in replication stress survival and drug resistance

Transcription/Replication Conflicts in Tumorigenesis and Their Potential Role as Novel Therapeutic Targets in Multiple Myeloma

Analysis of DNA replication profiles in budding yeast and mammalian cells using DNA combing

SAMHD1 and the innate immune response to cytosolic DNA during DNA replication

Interference Between DNA Replication and Transcription as a Cause of Genomic Instability

Topoisomerase I prevents transcription-replication conflicts at transcription termination sites

Toxic R-loops: Cause or consequence of replication stress?

TDP-43 dysfunction results in R-loop accumulation and DNA replication defects

Pharmacological Characterization and Molecular Determinants of the Activation of Transient Receptor Potential V2 Channel Orthologs by 2-Aminoethoxydiphenyl Borate

Impact of R-loops on oncogene-induced replication stress in cancer cells

Hair follicle stem cell replication stress drives IFI16/STING-dependent inflammation in hidradenitis suppurativa

Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma

MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling

Small-molecule inhibition of HIV pre-mRNA splicing as a novel antiretroviral therapy to overcome drug resistance

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