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Heme Modification Contributes to the Mechanism-Based Inactivation of Human Cytochrome P450 2J2 by Two Terminal Acetylenic Compounds

Drug metabolism and disposition, 2017-09, Vol.45 (9), p.990-999

2017

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The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5

The Journal of pharmacology and experimental therapeutics, 2005-04, Vol.313 (1), p.154-164

2005

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tert-Butylphenylacetylene Is a Potent Mechanism-Based Inactivator of Cytochrome P450 2B4: Inhibition of Cytochrome P450 Catalysis by Steric Hindrance

Molecular pharmacology, 2009-11, Vol.76 (5), p.1011-1018

2009

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Identification of the residue in human CYP3A4 that is covalently modified by bergamottin and the reactive intermediate that contributes to the grapefruit juice effect

Drug metabolism and disposition, 2012-05, Vol.40 (5), p.998-1006

2012

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Metabolic activation of mifepristone [RU486; 17beta-hydroxy-11beta-(4-dimethylaminophenyl)-17alpha-(1-propynyl)-estra-4,9-dien-3-one] by mammalian cytochromes P450 and the mechanism-based inactivation of human CYP2B6

The Journal of pharmacology and experimental therapeutics, 2009-04, Vol.329 (1), p.26-37

2009

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Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein

The Journal of pharmacology and experimental therapeutics, 2009-11, Vol.331 (2), p.392-403

2009

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The effect of ritonavir on human CYP2B6 catalytic activity: heme modification contributes to the mechanism-based inactivation of CYP2B6 and CYP3A4 by ritonavir

Drug metabolism and disposition, 2013-10, Vol.41 (10), p.1813-1824

2013

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Reaction of Human Cytochrome P450 3A4 with Peroxynitrite: Nitrotyrosine Formation on the Proximal Side Impairs Its Interaction with NADPH-Cytochrome P450 Reductase

Chemical research in toxicology, 2012-12, Vol.25 (12), p.2642-2653

2012

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Metabolism of bergamottin by cytochromes P450 2B6 and 3A5

The Journal of pharmacology and experimental therapeutics, 2006-09, Vol.318 (3), p.992-1005

2006

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Mechanism-based inactivation of human CYP2E1 by diethyldithocarbamate

Drug metabolism and disposition, 2010-12, Vol.38 (12), p.2286-2292

2010

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Roles of Residues F206 and V367 in Human CYP2B6: Effects of Mutations on Androgen Hydroxylation, Mechanism-Based Inactivation, and Reversible Inhibition

Drug metabolism and disposition, 2016-11, Vol.44 (11), p.1771-1779

2016

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Targeting of the highly conserved threonine 302 residue of cytochromes P450 2B family during mechanism-based inactivation by aryl acetylenes

Archives of biochemistry and biophysics, 2011-03, Vol.507 (1), p.135-143

2011

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Thr302 is the site for the covalent modification of human cytochrome P450 2B6 leading to mechanism-based inactivation by tert-butylphenylacetylene

Drug metabolism and disposition, 2011-12, Vol.39 (12), p.2431-2439

2011

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N-Nitrosodimethylamine-Mediated Formation of Oxidized and Methylated DNA Bases in a Cytochrome P450 2E1 Expressing Cell Line

Chemical research in toxicology, 2001-05, Vol.14 (5), p.562-566

2001

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Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity

Biochemistry (Easton), 2011-06, Vol.50 (22), p.4903-4911

2011

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Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism

Drug metabolism and disposition, 2013-01, Vol.41 (1), p.101-110

2013

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Inactivation of cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a thiophene-containing anticancer drug

Drug metabolism and disposition, 2011-02, Vol.39 (2), p.345-350

2011

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Peroxynitrite-Mediated Nitration of Tyrosine and Inactivation of the Catalytic Activity of Cytochrome P450 2B1

Chemical research in toxicology, 1998-09, Vol.11 (9), p.1067-1074

1998

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Peroxynitrite Inactivation of Human Cytochrome P450s 2B6 and 2E1: Heme Modification and Site-Specific Nitrotyrosine Formation

Chemical research in toxicology, 2007-11, Vol.20 (11), p.1612-1622

2007

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Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein

The Journal of pharmacology and experimental therapeutics, 2002-04, Vol.301 (1), p.160-167

2002

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The functional role of threonine-205 in the mechanism-based inactivation of P450 2B1 by two ethynyl substrates: the importance of the F helix in catalysis

The Journal of pharmacology and experimental therapeutics, 2004-12, Vol.311 (3), p.855-863

2004

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Regulation of Cytochrome P450 2E1 by Heat Shock Protein 90-Dependent Stabilization and CHIP-Dependent Proteasomal Degradation

Biochemistry (Easton), 2005-12, Vol.44 (49), p.16333-16340

2005

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The Highly Conserved Glu149 and Tyr190 Residues Contribute To Peroxynitrite-Mediated Nitrotyrosine Formation and the Catalytic Activity of Cytochrome P450 2B1

Chemical research in toxicology, 2005-08, Vol.18 (8), p.1203-1210

2005

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Mutation of Tyrosine 190 to Alanine Eliminates the Inactivation of Cytochrome P450 2B1 by Peroxynitrite

Chemical research in toxicology, 2003-02, Vol.16 (2), p.129-136

2003

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Identification of 17-α-Ethynylestradiol-Modified Active Site Peptides and Glutathione Conjugates Formed during Metabolism and Inactivation of P450s 2B1 and 2B6

Chemical research in toxicology, 2006-02, Vol.19 (2), p.279-287

2006

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Heme Modification Contributes to the Mechanism-Based Inactivation of Human Cytochrome P450 2J2 by Two Terminal Acetylenic Compounds

The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5

tert-Butylphenylacetylene Is a Potent Mechanism-Based Inactivator of Cytochrome P450 2B4: Inhibition of Cytochrome P450 Catalysis by Steric Hindrance

Identification of the residue in human CYP3A4 that is covalently modified by bergamottin and the reactive intermediate that contributes to the grapefruit juice effect

Metabolic activation of mifepristone [RU486; 17beta-hydroxy-11beta-(4-dimethylaminophenyl)-17alpha-(1-propynyl)-estra-4,9-dien-3-one] by mammalian cytochromes P450 and the mechanism-based inactivation of human CYP2B6

Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein

The effect of ritonavir on human CYP2B6 catalytic activity: heme modification contributes to the mechanism-based inactivation of CYP2B6 and CYP3A4 by ritonavir

Reaction of Human Cytochrome P450 3A4 with Peroxynitrite: Nitrotyrosine Formation on the Proximal Side Impairs Its Interaction with NADPH-Cytochrome P450 Reductase

Metabolism of bergamottin by cytochromes P450 2B6 and 3A5

Mechanism-based inactivation of human CYP2E1 by diethyldithocarbamate

Roles of Residues F206 and V367 in Human CYP2B6: Effects of Mutations on Androgen Hydroxylation, Mechanism-Based Inactivation, and Reversible Inhibition

Targeting of the highly conserved threonine 302 residue of cytochromes P450 2B family during mechanism-based inactivation by aryl acetylenes

Thr302 is the site for the covalent modification of human cytochrome P450 2B6 leading to mechanism-based inactivation by tert-butylphenylacetylene

N-Nitrosodimethylamine-Mediated Formation of Oxidized and Methylated DNA Bases in a Cytochrome P450 2E1 Expressing Cell Line

Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity

Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism

Inactivation of cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a thiophene-containing anticancer drug

Peroxynitrite-Mediated Nitration of Tyrosine and Inactivation of the Catalytic Activity of Cytochrome P450 2B1

Peroxynitrite Inactivation of Human Cytochrome P450s 2B6 and 2E1: Heme Modification and Site-Specific Nitrotyrosine Formation

Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein

The functional role of threonine-205 in the mechanism-based inactivation of P450 2B1 by two ethynyl substrates: the importance of the F helix in catalysis

Regulation of Cytochrome P450 2E1 by Heat Shock Protein 90-Dependent Stabilization and CHIP-Dependent Proteasomal Degradation

The Highly Conserved Glu149 and Tyr190 Residues Contribute To Peroxynitrite-Mediated Nitrotyrosine Formation and the Catalytic Activity of Cytochrome P450 2B1

Mutation of Tyrosine 190 to Alanine Eliminates the Inactivation of Cytochrome P450 2B1 by Peroxynitrite

Identification of 17-α-Ethynylestradiol-Modified Active Site Peptides and Glutathione Conjugates Formed during Metabolism and Inactivation of P450s 2B1 and 2B6

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