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Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

Science (American Association for the Advancement of Science), 2020-08, Vol.369 (6506), p.956-963

2020

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Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks

PLoS genetics, 2011-09, Vol.7 (9), p.e1002271-e1002271

2011

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Mre11 complex links sister chromatids to promote repair of a collapsed replication fork

Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (35), p.8793-8798

2018

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Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1

Molecular biology of the cell, 2018-06, Vol.29 (11), p.1389-1399

2018

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Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

Cell, 2009-10, Vol.139 (1), p.87-99

2009

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Critical Function of γH2A in S-Phase

PLoS genetics, 2015-09, Vol.11 (9), p.e1005517-e1005517

2015

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ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair

Nature structural & molecular biology, 2011-04, Vol.18 (4), p.423

2011

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Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast

PLoS genetics, 2017-09, Vol.13 (9), p.e1007013-e1007013

2017

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Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

Nature communications, 2022-09, Vol.13 (1), p.5236-5236, Article 5236

2022

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Tonoplast-localized Abc2 Transporter Mediates Phytochelatin Accumulation in Vacuoles and Confers Cadmium Tolerance

The Journal of biological chemistry, 2010-12, Vol.285 (52), p.40416-40426

2010

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Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast

PLoS genetics, 2010-09, Vol.6 (9), p.e1001138

2010

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Phosphorylation-regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaks

Cell cycle (Georgetown, Tex.), 2010-04, Vol.9 (8), p.1516-1522

2010

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Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways

iScience, 2022-09, Vol.25 (9), p.104914, Article 104914

2022

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Tolerance of Deregulated G1/S Transcription Depends on Critical G1/S Regulon Genes to Prevent Catastrophic Genome Instability

Cell reports (Cambridge), 2014-12, Vol.9 (6), p.2279-2289

2014

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RNase H eliminates R‐loops that disrupt DNA replication but is nonessential for efficient DSB repair

EMBO reports, 2018-05, Vol.19 (5), p.n/a

2018

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BRCT Domain Interactions with Phospho-Histone H2A Target Crb2 to Chromatin at Double-Strand Breaks and Maintain the DNA Damage Checkpoint

Molecular and Cellular Biology, 2010-10, Vol.30 (19), p.4732-4743

2010

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Regulation of the Rhp26ᴱᴿCC⁶/CSᴮ chromatin remodeler by a novel conserved leucine latch motif

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (52), p.18566-18571

2014

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Mre11 Nuclease Activity and Ctp1 Regulate Chk1 Activation by Rad3ATR and Tel1ATM Checkpoint Kinases at Double-Strand Breaks

Molecular and Cellular Biology, 2011-02, Vol.31 (3), p.573-583

2011

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Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease

Immunity (Cambridge, Mass.), 2023-03, Vol.56 (3), p.669-686.e7

2023

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ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

The EMBO journal, 2014-03, Vol.33 (5), p.482-500

2014

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Ctp1 Is a Cell-Cycle-Regulated Protein that Functions with Mre11 Complex to Control Double-Strand Break Repair by Homologous Recombination

Molecular cell, 2007-10, Vol.28 (1), p.134-146

2007

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Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress

Molecular and cellular biology, 2019-01, Vol.39 (2)

2019

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Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

Cell, 2008-10, Vol.135 (1), p.97-109

2008

Volltextzugriff (PDF)

Molecular basis of chromatin remodeling by Rhp26, a yeast CSB ortholog

Proceedings of the National Academy of Sciences - PNAS, 2019-03, Vol.116 (13), p.6120-6129

2019

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Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks

Mre11 complex links sister chromatids to promote repair of a collapsed replication fork

Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1

Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

HIV skews the SARS-CoV-2 B cell response towards an extrafollicular maturation pathway

Critical Function of γH2A in S-Phase

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair

Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast

Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

Tonoplast-localized Abc2 Transporter Mediates Phytochelatin Accumulation in Vacuoles and Confers Cadmium Tolerance

Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast

Phosphorylation-regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaks

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways

Tolerance of Deregulated G1/S Transcription Depends on Critical G1/S Regulon Genes to Prevent Catastrophic Genome Instability

RNase H eliminates R‐loops that disrupt DNA replication but is nonessential for efficient DSB repair

BRCT Domain Interactions with Phospho-Histone H2A Target Crb2 to Chromatin at Double-Strand Breaks and Maintain the DNA Damage Checkpoint

Regulation of the Rhp26ᴱᴿCC⁶/CSᴮ chromatin remodeler by a novel conserved leucine latch motif

Mre11 Nuclease Activity and Ctp1 Regulate Chk1 Activation by Rad3ATR and Tel1ATM Checkpoint Kinases at Double-Strand Breaks

Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

Ctp1 Is a Cell-Cycle-Regulated Protein that Functions with Mre11 Complex to Control Double-Strand Break Repair by Homologous Recombination

Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

Molecular basis of chromatin remodeling by Rhp26, a yeast CSB ortholog

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