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The gene repertoire of the main cysteine protease of Trypanosoma cruzi, cruzipain, reveals four sub-types with distinct active sites

Scientific reports, 2021-09, Vol.11 (1), p.18231-18231, Article 18231

2021

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Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host

PLoS neglected tropical diseases, 2021-06, Vol.15 (6), p.e0009526-e0009526

2021

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Crovirin, a snake venom cysteine-rich secretory protein (CRISP) with promising activity against Trypanosomes and Leishmania

PLoS neglected tropical diseases, 2014-10, Vol.8 (10), p.e3252

2014

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Tissue Specific Dual RNA-Seq Defines Host-Parasite Interplay in Murine Visceral Leishmaniasis Caused by Leishmania donovani and Leishmania infantum

Microbiology spectrum, 2022-04, Vol.10 (2), p.e0067922-e0067922

2022

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Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells

PLoS neglected tropical diseases, 2009-07, Vol.3 (7), p.e479

2009

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Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease

The Journal of clinical investigation, 2006-10, Vol.116 (10), p.2739-2747

2006

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A New Cruzipain-Mediated Pathway of Human Cell Invasion by Trypanosoma cruzi Requires Trypomastigote Membranes

Infection and Immunity, 2004-10, Vol.72 (10), p.5892-5902

2004

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Adipose Tissue-Derived Mesenchymal Stromal Cells Protect Mice Infected with Trypanosoma cruzi from Cardiac Damage through Modulation of Anti-parasite Immunity

PLoS neglected tropical diseases, 2015-08, Vol.9 (8), p.e0003945-e0003945

2015

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Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects

ACS infectious diseases, 2018-04, Vol.4 (4), p.467-477

2018

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Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence

Molecular microbiology, 2007-11, Vol.66 (4), p.991-1002

2007

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Toll-Like Receptor- and Protein Kinase R-Induced Type I Interferon Sustains Infection of Leishmania donovani in Macrophages

Frontiers in immunology, 2022-01, Vol.13, p.801182-801182

2022

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Role of protein kinase R in the killing of Leishmania major by macrophages in response to neutrophil elastase and TLR4 via TNFα and IFNβ

The FASEB journal, 2014-07, Vol.28 (7), p.3050-3063

2014

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Natural cysteine protease inhibitors in protozoa: Fifteen years of the chagasin family

Biochimie, 2016-03, Vol.122, p.197-207

2016

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The substrate specificity of cruzipain 2, a cysteine protease isoform from Trypanosoma cruzi

FEMS microbiology letters, 2006-06, Vol.259 (2), p.215-220

2006

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A promising pipeline of preclinical drug candidates for leishmaniasis and chronic Chagas’ disease

Trends in parasitology, 2024-03, Vol.40 (3), p.211-213

2024

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Leishmania inhibitor of serine peptidase 2 prevents TLR4 activation by neutrophil elastase promoting parasite survival in murine macrophages

The Journal of immunology (1950), 2011-01, Vol.186 (1), p.411-422

2011

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Cooperative Activation of TLR2 and Bradykinin B2 Receptor Is Required for Induction of Type 1 Immunity in a Mouse Model of Subcutaneous Infection by Trypanosoma cruzi

The Journal of immunology (1950), 2006-11, Vol.177 (9), p.6325-6335

2006

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The propeptide of cruzipain − a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F

The FEBS journal, 2007-03, Vol.274 (5), p.1224-1234

2007

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Toll-Like Receptors in Leishmania Infections: Guardians or Promoters?

Journal of Parasitology Research, 2012, Vol.2012, p.930257-12

2012

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Ecotin‐like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation

Cellular microbiology, 2012-08, Vol.14 (8), p.1271-1286

2012

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Chagasin, the endogenous cysteine-protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells

Journal of cell science, 2005-03, Vol.118 (5), p.901-915

2005

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The ecotin‐like peptidase inhibitor of Trypanosoma cruzi prevents TMPRSS2‐PAR2‐TLR4 crosstalk downmodulating infection and inflammation

The FASEB journal, 2024-03, Vol.38 (6), p.e23566-n/a

2024

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Substrate inhibition and allosteric regulation by heparan sulfate of Trypanosoma brucei cathepsin L

Biochimica et biophysica acta, 2012-03, Vol.1824 (3), p.493-501

2012

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Inhibitor of serine peptidase 2 enhances Leishmania major survival in the skin through control of monocytes and monocyte‐derived cells

The FASEB journal, 2018-03, Vol.32 (3), p.1315-1327

2018

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Toll-Like Receptor 3 (TLR3) Is Engaged in the Intracellular Survival of the Protozoan Parasite Leishmania (Leishmania) amazonensis

Infection and immunity, 2022-09, Vol.90 (9), p.e0032422-e0032422

2022

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The gene repertoire of the main cysteine protease of Trypanosoma cruzi, cruzipain, reveals four sub-types with distinct active sites

Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host

Crovirin, a snake venom cysteine-rich secretory protein (CRISP) with promising activity against Trypanosomes and Leishmania

Tissue Specific Dual RNA-Seq Defines Host-Parasite Interplay in Murine Visceral Leishmaniasis Caused by Leishmania donovani and Leishmania infantum

Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells

Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease

A New Cruzipain-Mediated Pathway of Human Cell Invasion by Trypanosoma cruzi Requires Trypomastigote Membranes

Adipose Tissue-Derived Mesenchymal Stromal Cells Protect Mice Infected with Trypanosoma cruzi from Cardiac Damage through Modulation of Anti-parasite Immunity

Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects

Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence

Toll-Like Receptor- and Protein Kinase R-Induced Type I Interferon Sustains Infection of Leishmania donovani in Macrophages

Role of protein kinase R in the killing of Leishmania major by macrophages in response to neutrophil elastase and TLR4 via TNFα and IFNβ

Natural cysteine protease inhibitors in protozoa: Fifteen years of the chagasin family

The substrate specificity of cruzipain 2, a cysteine protease isoform from Trypanosoma cruzi

A promising pipeline of preclinical drug candidates for leishmaniasis and chronic Chagas’ disease

Leishmania inhibitor of serine peptidase 2 prevents TLR4 activation by neutrophil elastase promoting parasite survival in murine macrophages

Cooperative Activation of TLR2 and Bradykinin B2 Receptor Is Required for Induction of Type 1 Immunity in a Mouse Model of Subcutaneous Infection by Trypanosoma cruzi

The propeptide of cruzipain − a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F

Toll-Like Receptors in Leishmania Infections: Guardians or Promoters?

Ecotin‐like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation

Chagasin, the endogenous cysteine-protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells

The ecotin‐like peptidase inhibitor of Trypanosoma cruzi prevents TMPRSS2‐PAR2‐TLR4 crosstalk downmodulating infection and inflammation

Substrate inhibition and allosteric regulation by heparan sulfate of Trypanosoma brucei cathepsin L

Inhibitor of serine peptidase 2 enhances Leishmania major survival in the skin through control of monocytes and monocyte‐derived cells

Toll-Like Receptor 3 (TLR3) Is Engaged in the Intracellular Survival of the Protozoan Parasite Leishmania (Leishmania) amazonensis

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