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Luteolin, apigenin, and chrysin inhibit lipotoxicity–induced NLRP3 inflammasome activation and autophagy damage in macrophages by suppressing endoplasmic reticulum stress

Environmental toxicology, 2024-08, Vol.39 (8), p.4120-4133

2024

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Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress

Free radical biology & medicine, 2011-12, Vol.51 (11), p.2073-2081

2011

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A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High-Cholesterol Diet

Nutrients, 2020-02, Vol.12 (2), p.523

2020

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Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes

Archives of toxicology, 2013-01, Vol.87 (1), p.167-178

2013

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Andrographolide mitigates cardiac apoptosis to provide cardio‐protection in high‐fat‐diet‐induced obese mice

Environmental toxicology, 2020-06, Vol.35 (6), p.707-713

2020

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Andrographolide Inhibits Oxidized LDL-Induced Cholesterol Accumulation and Foam Cell Formation in Macrophages

The American journal of Chinese medicine (1979), 2018-01, Vol.46 (1), p.87-106

2018

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Isothiocyanates protect against oxidized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFκB activation

Molecular nutrition & food research, 2013-11, Vol.57 (11), p.1918-1930

2013

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Andrographolide Inhibits Lipotoxicity-Induced Activation of the NLRP3 Inflammasome in Bone Marrow-Derived Macrophages

The American journal of Chinese medicine (1979), 2023-01, Vol.51 (1), p.129-147

2023

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Andrographis paniculata Improves Insulin Resistance in High-Fat Diet-Induced Obese Mice and TNFα-Treated 3T3-L1 Adipocytes

The American journal of Chinese medicine (1979), 2020-01, Vol.48 (5), p.1073-1090

2020

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Does garlic have a role as an antidiabetic agent

Molecular nutrition & food research, 2007-11, Vol.51 (11), p.1353-1364

2007

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Docosahexaenoic Acid Inhibits Vascular Endothelial Growth Factor (VEGF)-Induced Cell Migration via the GPR120/PP2A/ERK1/2/eNOS Signaling Pathway in Human Umbilical Vein Endothelial Cells

Journal of agricultural and food chemistry, 2014-05, Vol.62 (18), p.4152-4158

2014

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14-Deoxy-11,12-Didehydroandrographolide Ameliorates Glucose Intolerance Enhancing the LKB1/AMPKα/TBC1D1/GLUT4 Signaling Pathway and Inducing GLUT4 Expression in Myotubes and Skeletal Muscle of Obese Mice

The American journal of Chinese medicine (1979), 2021-01, Vol.49 (6), p.1473-1491

2021

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Flavonoids protect pancreatic beta-cells from cytokines mediated apoptosis through the activation of PI3-kinase pathway

Cytokine (Philadelphia, Pa.), 2012-07, Vol.59 (1), p.65-71

2012

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IP3 and calcium signaling involved in the reorganization of the actin cytoskeleton and cell rounding induced by cigarette smoke extract in human endothelial cells

Environmental toxicology, 2016-11, Vol.31 (11), p.1293-1306

2016

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Sulforaphane inhibits TNF-α-induced adhesion molecule expression through the Rho A/ROCK/NF-κB signaling pathway

Journal of medicinal food, 2014-10, Vol.17 (10), p.1095-1102

2014

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Quercetin enhances the antitumor effect of trichostatin A and suppresses muscle wasting in tumor-bearing mice

Food & function, 2018-02, Vol.9 (2), p.871-879

2018

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Docosahexaenoic acid inhibits inflammation via free fatty acid receptor FFA4, disruption of TAB2 interaction with TAK1/TAB1 and downregulation of ERK‐dependent Egr‐1 expression in EA.hy926 cells

Molecular nutrition & food research, 2016-02, Vol.60 (2), p.430-443

2016

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Freshwater clam extract reduces liver injury by lowering cholesterol accumulation, improving dysregulated cholesterol synthesis and alleviating inflammation in high-fat, high-cholesterol and cholic acid diet-induced steatohepatitis in mice

Food & function, 2018-09, Vol.9 (9), p.4876-4887

2018

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Andrographolide inhibits hypoxia‐induced hypoxia‐inducible factor 1α and endothelin 1 expression through the heme oxygenase 1/CO/cGMP/MKP‐5 pathways in EA.hy926 cells

Environmental toxicology, 2018-03, Vol.33 (3), p.269-279

2018

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Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells

Archives of toxicology, 2013-05, Vol.87 (5), p.857-869

2013

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Diallyl trisulfide suppresses the adipogenesis of 3T3-L1 preadipocytes through ERK activation

Food and chemical toxicology, 2012-03, Vol.50 (3-4), p.478-484

2012

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Andrographolide inhibits hypoxia‐induced HIF‐1α‐driven endothelin 1 secretion by activating Nrf2/HO‐1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells

Environmental toxicology, 2017-03, Vol.32 (3), p.918-930

2017

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Soy isoflavones reduce acetaminophen-induced liver injury by inhibiting cytochrome P-450-mediated bioactivation and glutathione depletion and increasing urinary drug excretion in rats

Journal of functional foods, 2016-10, Vol.26, p.135-143

2016

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Diallyl disulfide and diallyl trisulfide protect endothelial nitric oxide synthase against damage by oxidized low-density lipoprotein

Molecular nutrition & food research, 2010-05, Vol.54 (S1), p.S42-S52

2010

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Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats

Toxicology and applied pharmacology, 2014-10, Vol.280 (1), p.1-9

2014

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Luteolin, apigenin, and chrysin inhibit lipotoxicity–induced NLRP3 inflammasome activation and autophagy damage in macrophages by suppressing endoplasmic reticulum stress

Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress

A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High-Cholesterol Diet

Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes

Andrographolide mitigates cardiac apoptosis to provide cardio‐protection in high‐fat‐diet‐induced obese mice

Andrographolide Inhibits Oxidized LDL-Induced Cholesterol Accumulation and Foam Cell Formation in Macrophages

Isothiocyanates protect against oxidized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFκB activation

Andrographolide Inhibits Lipotoxicity-Induced Activation of the NLRP3 Inflammasome in Bone Marrow-Derived Macrophages

Andrographis paniculata Improves Insulin Resistance in High-Fat Diet-Induced Obese Mice and TNFα-Treated 3T3-L1 Adipocytes

Does garlic have a role as an antidiabetic agent

Docosahexaenoic Acid Inhibits Vascular Endothelial Growth Factor (VEGF)-Induced Cell Migration via the GPR120/PP2A/ERK1/2/eNOS Signaling Pathway in Human Umbilical Vein Endothelial Cells

14-Deoxy-11,12-Didehydroandrographolide Ameliorates Glucose Intolerance Enhancing the LKB1/AMPKα/TBC1D1/GLUT4 Signaling Pathway and Inducing GLUT4 Expression in Myotubes and Skeletal Muscle of Obese Mice

Flavonoids protect pancreatic beta-cells from cytokines mediated apoptosis through the activation of PI3-kinase pathway

IP3 and calcium signaling involved in the reorganization of the actin cytoskeleton and cell rounding induced by cigarette smoke extract in human endothelial cells

Sulforaphane inhibits TNF-α-induced adhesion molecule expression through the Rho A/ROCK/NF-κB signaling pathway

Quercetin enhances the antitumor effect of trichostatin A and suppresses muscle wasting in tumor-bearing mice

Docosahexaenoic acid inhibits inflammation via free fatty acid receptor FFA4, disruption of TAB2 interaction with TAK1/TAB1 and downregulation of ERK‐dependent Egr‐1 expression in EA.hy926 cells

Freshwater clam extract reduces liver injury by lowering cholesterol accumulation, improving dysregulated cholesterol synthesis and alleviating inflammation in high-fat, high-cholesterol and cholic acid diet-induced steatohepatitis in mice

Andrographolide inhibits hypoxia‐induced hypoxia‐inducible factor 1α and endothelin 1 expression through the heme oxygenase 1/CO/cGMP/MKP‐5 pathways in EA.hy926 cells

Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells

Diallyl trisulfide suppresses the adipogenesis of 3T3-L1 preadipocytes through ERK activation

Andrographolide inhibits hypoxia‐induced HIF‐1α‐driven endothelin 1 secretion by activating Nrf2/HO‐1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells

Soy isoflavones reduce acetaminophen-induced liver injury by inhibiting cytochrome P-450-mediated bioactivation and glutathione depletion and increasing urinary drug excretion in rats

Diallyl disulfide and diallyl trisulfide protect endothelial nitric oxide synthase against damage by oxidized low-density lipoprotein

Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats

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