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Evaluation and comparison of computational tools for RNA-seq isoform quantification

BMC genomics, 2017-08, Vol.18 (1), p.583-583, Article 583

2017

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Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues

Nature immunology, 2019-08, Vol.20 (8), p.980

2019

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The Interleukin‐1 Receptor–Associated Kinase 4 Inhibitor PF‐06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial

Arthritis & rheumatology (Hoboken, N.J.), 2021-12, Vol.73 (12), p.2206-2218

2021

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Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation

The Journal of immunology (1950), 2016-09, Vol.197 (6), p.2421-2433

2016

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The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts

Annals of the rheumatic diseases, 2016-02, Vol.75 (2), p.422-429

2016

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IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes

The Journal of biological chemistry, 2017-11, Vol.292 (45), p.18689-18698

2017

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Microbial dysbiosis and childhood asthma development: Integrated role of the airway and gut microbiome, environmental exposures, and host metabolic and immune response

Frontiers in immunology, 2022-09, Vol.13, p.1028209-1028209

2022

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Computational identification and validation of alternative splicing in ZSF1 rat RNA-seq data, a preclinical model for type 2 diabetic nephropathy

Scientific reports, 2018-05, Vol.8 (1), p.7624-8, Article 7624

2018

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Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course

Scientific reports, 2020-06, Vol.10 (1), p.8830, Article 8830

2020

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MAPKAP Kinase 2-Deficient Mice Are Resistant to Collagen-Induced Arthritis

Journal of Immunology, 2006-08, Vol.177 (3), p.1913-1917

2006

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Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality

Journal of leukocyte biology, 2010-12, Vol.88 (6), p.1171-1180

2010

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CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE

JCI insight, 2021-11, Vol.6 (21)

2021

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Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor-Induced Myocarditis

Circulation (New York, N.Y.), 2022-07, Vol.146 (4), p.316-335

2022

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Distinct Cellular Functions of MK2

Molecular and Cellular Biology, 2002-07, Vol.22 (13), p.4827-4835

2002

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Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5521-5542

2017

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Identification and SAR of a new series of thieno[3,2- d]pyrimidines as Tpl2 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (19), p.5952-5956

2011

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Pharmacologic Inhibition of Tpl2 Blocks Inflammatory Responses in Primary Human Monocytes, Synoviocytes, and Blood

The Journal of biological chemistry, 2007-11, Vol.282 (46), p.33295-33304

2007

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Lysine Methyltransferase SETD7 (SET7/9) Regulates ROS Signaling through mitochondria and NFE2L2/ARE pathway

Scientific reports, 2015-10, Vol.5 (1), p.14368-14368, Article 14368

2015

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Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation

Cell research, 2023-02, Vol.33 (2), p.131-146

2023

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TRIL, a Functional Component of the TLR4 Signaling Complex, Highly Expressed in Brain

The Journal of immunology (1950), 2009-09, Vol.183 (6), p.3989-3995

2009

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Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling

The Journal of biological chemistry, 2018-09, Vol.293 (39), p.15208-15220

2018

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Calcium-mediated Translocation of Cytosolic Phospholipase A2 to the Nuclear Envelope and Endoplasmic Reticulum (∗)

The Journal of biological chemistry, 1995-12, Vol.270 (51), p.30749-30754

1995

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Innate Immune Responses to TREM-1 Activation: Overlap, Divergence, and Positive and Negative Cross-Talk with Bacterial Lipopolysaccharide

The Journal of immunology (1950), 2008-03, Vol.180 (5), p.3520-3534

2008

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Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner

The Journal of biological chemistry, 2014-04, Vol.289 (15), p.10865-10875

2014

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Evaluation and comparison of computational tools for RNA-seq isoform quantification

Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues

The Interleukin‐1 Receptor–Associated Kinase 4 Inhibitor PF‐06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial

Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation

The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay

IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes

Microbial dysbiosis and childhood asthma development: Integrated role of the airway and gut microbiome, environmental exposures, and host metabolic and immune response

Computational identification and validation of alternative splicing in ZSF1 rat RNA-seq data, a preclinical model for type 2 diabetic nephropathy

Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course

MAPKAP Kinase 2-Deficient Mice Are Resistant to Collagen-Induced Arthritis

Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality

CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE

Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor-Induced Myocarditis

Distinct Cellular Functions of MK2

Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Identification and SAR of a new series of thieno[3,2- d]pyrimidines as Tpl2 kinase inhibitors

Pharmacologic Inhibition of Tpl2 Blocks Inflammatory Responses in Primary Human Monocytes, Synoviocytes, and Blood

Lysine Methyltransferase SETD7 (SET7/9) Regulates ROS Signaling through mitochondria and NFE2L2/ARE pathway

Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation

TRIL, a Functional Component of the TLR4 Signaling Complex, Highly Expressed in Brain

Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling

Calcium-mediated Translocation of Cytosolic Phospholipase A2 to the Nuclear Envelope and Endoplasmic Reticulum (∗)

Innate Immune Responses to TREM-1 Activation: Overlap, Divergence, and Positive and Negative Cross-Talk with Bacterial Lipopolysaccharide

Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner

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