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Metabolism and Pharmacokinetic Studies of JPH203, an L-Amino Acid Transporter 1 (LAT1) Selective Compound

DRUG METABOLISM AND PHARMACOKINETICS, 2012, Vol.27 (1), p.155-161

2012

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Achyrocline B (3,5 dihydroxy-6,7,8-trimethoxyflavone) synergizes with 5-fluorouracil allowing for dose reduction and reduced off-target toxicity in the treatment of colonic and pancreatic cancers

Biomedicine & pharmacotherapy, 2023-11, Vol.167, p.115546-115546, Article 115546

2023

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Upregulation of pERK and c-JUN by γ-tocotrienol and not α-tocopherol are essential to the differential effect on apoptosis in prostate cancer cells

BMC cancer, 2020-05, Vol.20 (1), p.428-10, Article 428

2020

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γ-Tocotrienol induces apoptosis in pancreatic cancer cells by upregulation of ceramide synthesis and modulation of sphingolipid transport

BMC cancer, 2018-05, Vol.18 (1), p.564-564, Article 564

2018

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Circulating GDF-15: a biomarker for metabolic dysregulation and aging in people living with HIV

Frontiers in aging, 2024-06, Vol.5, p.1414866

2024

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Inhibiting efflux with novel non-ionic surfactants: Rational design based on vitamin E TPGS

International journal of pharmaceutics, 2009-03, Vol.370 (1), p.93-102

2009

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Anti-neoplastic activity of two flavone isomers derived from Gnaphalium elegans and Achyrocline bogotensis

PloS one, 2012-06, Vol.7 (6), p.e39806-e39806

2012

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A specific molecular beacon probe for the detection of human prostate cancer cells

Bioorganic & medicinal chemistry letters, 2012-06, Vol.22 (11), p.3632-3638

2012

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Abstract 1274: Metformin, not γ-tocotrienol, increases gene methylation and decreases expression of genes responsible for cell signal transduction in prostate cancer cells

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.1274-1274

2020

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Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies

Drug design, development and therapy, 2012, Vol.6 (default), p.323-339

2012

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Abstract 3977: γ-Tocotrienol and metformin are cytotoxic to prostate cancer cell lines and exhibit synergy

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.3977-3977

2018

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Cytotoxic Effects of Metformin and Gamma-Tocotrienol on Colon Cancer Cells: 153

The American journal of gastroenterology, 2017-10, Vol.112, p.S77

2017

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Precision prostate cancer chemoprevention with gamma-tocotrienol

Journal of clinical oncology, 2017-05, Vol.35 (15_suppl), p.e13043-e13043

2017

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Investigating idebenone and idebenone linoleate metabolism: in vitro pig ear and mouse melanocyte studies

Journal of cosmetic dermatology, 2009-03, Vol.8 (1), p.63-73

2009

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AKT1 Activation Up Regulates Peroxiredoxin 1 in Human Melanoma Cells

Free radical biology & medicine, 2016-11, Vol.100, p.S130

2016

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300 - AKT1 Activation Up Regulates Peroxiredoxin 1 in Human Melanoma Cells

Free radical biology & medicine, 2016-11, Vol.100, p.S130-S130

2016

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Abstract 3568: Delta-tocotrienol and simvastatin induce cytotoxicity and synergy in BRAF mutant SK-MEL-28 but not in wild type BRAF SK-MEL-2 melanoma cancer cells

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.3568-3568

2016

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Abstract 3567: Metformin suppresses synthesis of pro-survival sphingolipid, sphingosine-1-phosphate, by inhibition of sphingosine kinase-1, in MCF-7 and SK-BR-3 breast cancer cell lines

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.3567-3567

2016

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Tocotrienols inhibit AKT and ERK activation and suppress pancreatic cancer cell proliferation by suppressing the ErbB2 pathway

Free radical biology & medicine, 2011-09, Vol.51 (6), p.1164-1174

2011

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Gamma-Tocotrienol and Simvastatin Synergistically Induce Cytotoxicity In Leukemia Cell Lines, K-562 and HL-60

Blood, 2013-11, Vol.122 (21), p.4927-4927

2013

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Abstract 4639: Metformin decreases cellular ceramides in MCF-7 and MDA-MB 231 breast cancer cell lines by inhibition of ceramide synthetic enzymes

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.4639-4639

2015

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Synergistic growth inhibition of PC3 prostate cancer cells with low-dose combinations of simvastatin and alendronate

Anticancer research, 2015-04, Vol.35 (4), p.1851-1859

2015

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Abstract 2106: Gamma-tocotrienol upregulates the ceramide transporter, Arv-1, in pancreatic cancer cells

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.2106-2106

2013

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Abstract 4351: Gamma-tocotrienol not alpha-tocopherol is cytotoxic to prostate cancer cells through modulation of phospho-c-Jun and phospho-Erk

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.4351-4351

2013

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γ-Tocotrienol induces growth arrest through a novel pathway with TGFβ2 in prostate cancer

Free radical biology & medicine, 2011-05, Vol.50 (10), p.1344-1354

2011

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Metabolism and Pharmacokinetic Studies of JPH203, an L-Amino Acid Transporter 1 (LAT1) Selective Compound

Achyrocline B (3,5 dihydroxy-6,7,8-trimethoxyflavone) synergizes with 5-fluorouracil allowing for dose reduction and reduced off-target toxicity in the treatment of colonic and pancreatic cancers

Upregulation of pERK and c-JUN by γ-tocotrienol and not α-tocopherol are essential to the differential effect on apoptosis in prostate cancer cells

γ-Tocotrienol induces apoptosis in pancreatic cancer cells by upregulation of ceramide synthesis and modulation of sphingolipid transport

Circulating GDF-15: a biomarker for metabolic dysregulation and aging in people living with HIV

Inhibiting efflux with novel non-ionic surfactants: Rational design based on vitamin E TPGS

Anti-neoplastic activity of two flavone isomers derived from Gnaphalium elegans and Achyrocline bogotensis

A specific molecular beacon probe for the detection of human prostate cancer cells

Abstract 1274: Metformin, not γ-tocotrienol, increases gene methylation and decreases expression of genes responsible for cell signal transduction in prostate cancer cells

Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies

Abstract 3977: γ-Tocotrienol and metformin are cytotoxic to prostate cancer cell lines and exhibit synergy

Cytotoxic Effects of Metformin and Gamma-Tocotrienol on Colon Cancer Cells: 153

Precision prostate cancer chemoprevention with gamma-tocotrienol

Investigating idebenone and idebenone linoleate metabolism: in vitro pig ear and mouse melanocyte studies

AKT1 Activation Up Regulates Peroxiredoxin 1 in Human Melanoma Cells

300 - AKT1 Activation Up Regulates Peroxiredoxin 1 in Human Melanoma Cells

Abstract 3568: Delta-tocotrienol and simvastatin induce cytotoxicity and synergy in BRAF mutant SK-MEL-28 but not in wild type BRAF SK-MEL-2 melanoma cancer cells

Abstract 3567: Metformin suppresses synthesis of pro-survival sphingolipid, sphingosine-1-phosphate, by inhibition of sphingosine kinase-1, in MCF-7 and SK-BR-3 breast cancer cell lines

Tocotrienols inhibit AKT and ERK activation and suppress pancreatic cancer cell proliferation by suppressing the ErbB2 pathway

Gamma-Tocotrienol and Simvastatin Synergistically Induce Cytotoxicity In Leukemia Cell Lines, K-562 and HL-60

Abstract 4639: Metformin decreases cellular ceramides in MCF-7 and MDA-MB 231 breast cancer cell lines by inhibition of ceramide synthetic enzymes

Synergistic growth inhibition of PC3 prostate cancer cells with low-dose combinations of simvastatin and alendronate

Abstract 2106: Gamma-tocotrienol upregulates the ceramide transporter, Arv-1, in pancreatic cancer cells

Abstract 4351: Gamma-tocotrienol not alpha-tocopherol is cytotoxic to prostate cancer cells through modulation of phospho-c-Jun and phospho-Erk

γ-Tocotrienol induces growth arrest through a novel pathway with TGFβ2 in prostate cancer

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