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Design and Synthesis of Tetrahydropyridothieno[2,3-d]pyrimidine Scaffold Based Epidermal Growth Factor Receptor (EGFR) Kinase Inhibitors: The Role of Side Chain Chirality and Michael Acceptor Group for Maximal Potency

Journal of medicinal chemistry, 2010-10, Vol.53 (20), p.7316-7326

2010

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Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells

Biochemical pharmacology, 2011-06, Vol.81 (11), p.1263-1270

2011

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BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

PloS one, 2011-08, Vol.6 (8), p.e23485

2011

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Indol-1-yl Acetic Acids as Peroxisome Proliferator-Activated Receptor Agonists: Design, Synthesis, Structural Biology, and Molecular Docking Studies

Journal of medicinal chemistry, 2006-02, Vol.49 (3), p.1212-1216

2006

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Development of Furanopyrimidine-Based Orally Active Third-Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung Cancer

Journal of medicinal chemistry, 2023-02, Vol.66 (4), p.2566-2588

2023

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Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer

Journal of medicinal chemistry, 2019-11, Vol.62 (22), p.10108-10123

2019

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Bioassay-guided purification and identification of PPARα/γ agonists from Chlorella sorokiniana

Phytotherapy research, 2008-05, Vol.22 (5), p.605-613

2008

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Fast-Forwarding Hit to Lead: Aurora and Epidermal Growth Factor Receptor Kinase Inhibitor Lead Identification

Journal of medicinal chemistry, 2010-07, Vol.53 (13), p.4980-4988

2010

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Structure-Based Drug Design of Novel Aurora Kinase A Inhibitors: Structural Basis for Potency and Specificity

Journal of medicinal chemistry, 2009-02, Vol.52 (4), p.1050-1062

2009

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Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system

Bioorganic & medicinal chemistry, 2006, Vol.14 (1), p.83-91

2006

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Inhibition of Hepatitis C Virus Replication by Antimonial Compounds

Antimicrobial Agents and Chemotherapy, 2005-10, Vol.49 (10), p.4197-4202

2005

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Structure-Based Drug Design of a Novel Family of PPARγ Partial Agonists: Virtual Screening, X-ray Crystallography, and in Vitro/in Vivo Biological Activities

Journal of medicinal chemistry, 2006-05, Vol.49 (9), p.2703-2712

2006

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Novel Indole-Based Peroxisome Proliferator-Activated Receptor Agonists: Design, SAR, Structural Biology, and Biological Activities

Journal of medicinal chemistry, 2005-12, Vol.48 (26), p.8194-8208

2005

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Haemolymph parameters of Pacific white shrimp (Litopenaeus vannamei) infected with Taura syndrome virus

Fish & shellfish immunology, 2003-04, Vol.14 (4), p.317-331

2003

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Design and Structural Analysis of Novel Pharmacophores for Potent and Selective Peroxisome Proliferator-activated Receptor γ Agonists

Journal of medicinal chemistry, 2009-04, Vol.52 (8), p.2618-2622

2009

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Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents

Investigational new drugs, 2012-02, Vol.30 (1), p.164-175

2012

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A High-throughput Cell-based Screening for L858R/T790M Mutant Epidermal Growth Factor Receptor Inhibitors

Anticancer research, 2012, Vol.32 (1), p.147-151

2012

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Structural Basis for the Structure−Activity Relationships of Peroxisome Proliferator-Activated Receptor Agonists

Journal of medicinal chemistry, 2006-10, Vol.49 (21), p.6421-6424

2006

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A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors

Analytical biochemistry, 2008-06, Vol.377 (1), p.89-94

2008

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Genomic similarity of Taura syndrome virus (TSV) between Taiwan and Western Hemisphere isolates

Fish Pathology, 2002/06/15, Vol.37(2), pp.71-75

2002

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High-throughput cell-based screening for hepatitis C virus NS3/4A protease inhibitors

Assay and drug development technologies, 2005-08, Vol.3 (4), p.385-392

2005

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BPR1K653, a Novel Aurora Kinase Inhibitor, Exhibits Potent Anti-Proliferative Activity in MDR1

PloS one, 2011-08, Vol.6 (8), p.e23485

2011

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Structural Basis for the Improved Potency of Peroxisome Proliferator-Activated Receptor (PPAR) Agonists

ChemMedChem, 2010-10, Vol.5 (10), p.1707-1716

2010

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Notice of Retraction: Disulfiram is a Novel Modulator for PPAR

2011 5th International Conference on Bioinformatics and Biomedical Engineering, 2011, p.1-4

2011

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Design and Structural Analysis of Novel Pharmacophores for Potent and Selective Peroxisome Proliferator-activated Receptor y Agonists

Journal of medicinal chemistry, 2009, Vol.52 (8), p.2618-2622

2009

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Design and Synthesis of Tetrahydropyridothieno[2,3-d]pyrimidine Scaffold Based Epidermal Growth Factor Receptor (EGFR) Kinase Inhibitors: The Role of Side Chain Chirality and Michael Acceptor Group for Maximal Potency

Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells

BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

Indol-1-yl Acetic Acids as Peroxisome Proliferator-Activated Receptor Agonists: Design, Synthesis, Structural Biology, and Molecular Docking Studies

Development of Furanopyrimidine-Based Orally Active Third-Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung Cancer

Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer

Bioassay-guided purification and identification of PPARα/γ agonists from Chlorella sorokiniana

Fast-Forwarding Hit to Lead: Aurora and Epidermal Growth Factor Receptor Kinase Inhibitor Lead Identification

Structure-Based Drug Design of Novel Aurora Kinase A Inhibitors: Structural Basis for Potency and Specificity

Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system

Inhibition of Hepatitis C Virus Replication by Antimonial Compounds

Structure-Based Drug Design of a Novel Family of PPARγ Partial Agonists: Virtual Screening, X-ray Crystallography, and in Vitro/in Vivo Biological Activities

Novel Indole-Based Peroxisome Proliferator-Activated Receptor Agonists: Design, SAR, Structural Biology, and Biological Activities

Haemolymph parameters of Pacific white shrimp (Litopenaeus vannamei) infected with Taura syndrome virus

Design and Structural Analysis of Novel Pharmacophores for Potent and Selective Peroxisome Proliferator-activated Receptor γ Agonists

Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents

A High-throughput Cell-based Screening for L858R/T790M Mutant Epidermal Growth Factor Receptor Inhibitors

Structural Basis for the Structure−Activity Relationships of Peroxisome Proliferator-Activated Receptor Agonists

A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors

Genomic similarity of Taura syndrome virus (TSV) between Taiwan and Western Hemisphere isolates

High-throughput cell-based screening for hepatitis C virus NS3/4A protease inhibitors

BPR1K653, a Novel Aurora Kinase Inhibitor, Exhibits Potent Anti-Proliferative Activity in MDR1

Structural Basis for the Improved Potency of Peroxisome Proliferator-Activated Receptor (PPAR) Agonists

Notice of Retraction: Disulfiram is a Novel Modulator for PPAR

Design and Structural Analysis of Novel Pharmacophores for Potent and Selective Peroxisome Proliferator-activated Receptor y Agonists

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