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A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

Neurology, 2009-12, Vol.73 (24), p.2061

2009

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Amyloid precursor protein processing and Aβ42 deposition in a transgenic mouse model of Alzheimer disease

Proceedings of the National Academy of Sciences - PNAS, 1997-02, Vol.94 (4), p.1550-1555

1997

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beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

The Journal of neuroscience, 1992-02, Vol.12 (2), p.376-389

1992

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Reduction of β-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease

Annals of neurology, 1995-10, Vol.38 (4), p.643-648

1995

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Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro

Molecular pharmacology, 1994-03, Vol.45 (3), p.373-379

1994

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Cellular Mechanisms of β -Amyloid Production and Secretion

Proceedings of the National Academy of Sciences - PNAS, 1999-09, Vol.96 (20), p.11049-11053

1999

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Elevation of microtubule-associated protein tau in the cerebrospinal fluid of patients with Alzheimer's disease

Neurology, 1995-04, Vol.45 (4), p.788

1995

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A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

Nature (London), 1988-02, Vol.331 (6156), p.525-527

1988

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Estrogen therapy in postmenopausal women: effects on cognitive function and dementia

JAMA : the journal of the American Medical Association, 1998-03, Vol.279 (9), p.688

1998

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The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway

The Journal of biological chemistry, 1990-03, Vol.265 (8), p.4492-4497

1990

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Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Nature medicine, 2000-08, Vol.6 (8), p.916-919

2000

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Identification of a Stable Fragment of the Alzheimer Amyloid Precursor Containing the β-Protein in Brain Microvessels

Proceedings of the National Academy of Sciences - PNAS, 1992-02, Vol.89 (4), p.1345-1349

1992

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Channel Formation in Planar Lipid Bilayers by a Neurotoxic Fragment of the β-Amyloid Peptide

Biochemical and biophysical research communications, 1994-07, Vol.202 (2), p.1142-1148

1994

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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Nature (London), 1999-07, Vol.400 (6740), p.173-177

1999

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Altered Calcium Signaling and Neuronal Injury: Stroke and Alzheimer's Disease as Examples

Annals of the New York Academy of Sciences, 1993-05, Vol.679 (1), p.1-21

1993

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Purification and cloning of amyloid precursor protein β-secretase from human brain

Nature (London), 1999-12, Vol.402 (6761), p.537-540

1999

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Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. Identification of a novel, 22-kDa, beta-peptide-containing intermediate

The Journal of biological chemistry, 1992-08, Vol.267 (23), p.16022-16024

1992

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Nature medicine, 1997-01, Vol.3 (1), p.67-72

1997

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Regulated cleavage of alzheimer β-amyloid precursor protein in the absence of the cytoplasmic tail

Neuroscience, 1993-12, Vol.57 (4), p.873-877

1993

Volltextzugriff (PDF)

Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein [published errratum appears in Mol Cell Biol 1987 May;7(5):2035]

Molecular and Cellular Biology, 1987-02, Vol.7 (2), p.914-920

1987

Volltextzugriff (PDF)

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Nature (London), 1992-12, Vol.360 (6405), p.672-674

1992

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Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

Nature (London), 1992-09, Vol.359 (6393), p.325-327

1992

Volltextzugriff (PDF)

The protease inhibitory properties of the Alzheimer's beta-amyloid precursor protein

The Journal of biological chemistry, 1990-06, Vol.265 (16), p.8983-8985

1990

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Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity

The American journal of pathology, 1993-01, Vol.142 (1), p.17-24

1993

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A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

Amyloid precursor protein processing and Aβ42 deposition in a transgenic mouse model of Alzheimer disease

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

Reduction of β-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease

Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro

Cellular Mechanisms of β -Amyloid Production and Secretion

Elevation of microtubule-associated protein tau in the cerebrospinal fluid of patients with Alzheimer's disease

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

Estrogen therapy in postmenopausal women: effects on cognitive function and dementia

The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Identification of a Stable Fragment of the Alzheimer Amyloid Precursor Containing the β-Protein in Brain Microvessels

Channel Formation in Planar Lipid Bilayers by a Neurotoxic Fragment of the β-Amyloid Peptide

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Altered Calcium Signaling and Neuronal Injury: Stroke and Alzheimer's Disease as Examples

Purification and cloning of amyloid precursor protein β-secretase from human brain

Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. Identification of a novel, 22-kDa, beta-peptide-containing intermediate

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Regulated cleavage of alzheimer β-amyloid precursor protein in the absence of the cytoplasmic tail

Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein [published errratum appears in Mol Cell Biol 1987 May;7(5):2035]

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

The protease inhibitory properties of the Alzheimer's beta-amyloid precursor protein

Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity

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