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Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development

Cancer immunology research, 2019-08, Vol.7 (8), p.1244-1257

2019

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Blocking LAIR1 signaling in immune cells inhibits tumor development

Frontiers in immunology, 2022-09, Vol.13, p.996026

2022

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Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor

Drug metabolism and disposition, 2011-10, Vol.39 (10), p.1840

2011

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Phase 1 Randomized, Double-Blind, Placebo-Controlled Study of RG7667, an Anticytomegalovirus Combination Monoclonal Antibody Therapy, in Healthy Adults

Antimicrobial agents and chemotherapy, 2015-08, Vol.59 (8), p.4919-4929

2015

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304 Antagonistic antibodies targeting LAIR1 enhance T lymphocyte activation and promote inflammatory phenotypes in myeloid cells

Journal for immunotherapy of cancer, 2021-11, Vol.9 (Suppl 2), p.A327-A327

2021

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686 Preclinical characterization of a novel therapeutic antibody targeting LILRB2

Journal for immunotherapy of cancer, 2020-11, Vol.8 (Suppl 3), p.A411-A412

2020

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Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of RG7667, a Combination Monoclonal Antibody, for Prevention of Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients

Antimicrobial agents and chemotherapy, 2017-02, Vol.61 (2)

2017

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A randomized trial of the efficacy and safety of quilizumab in adults with inadequately controlled allergic asthma

Respiratory research, 2016-03, Vol.17 (29), p.29-29, Article 29

2016

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Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production

Science translational medicine, 2014-07, Vol.6 (243), p.243ra85

2014

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Pharmacokinetics and Exposure-Response Analysis of RG7667, a Combination of Two Anticytomegalovirus Monoclonal Antibodies, in a Phase 2a Randomized Trial To Prevent Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients

Antimicrobial agents and chemotherapy, 2018-02, Vol.62 (2)

2018

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Racial profiling harms science

Science (American Association for the Advancement of Science), 2019-03, Vol.363 (6433), p.1290-1292

2019

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Impaired Cytokine Signaling in Mice Lacking the IL-1 Receptor-Associated Kinase

The Journal of immunology (1950), 1999-07, Vol.163 (2), p.978-984

1999

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A Novel E3 Ubiquitin Ligase TRAC-1 Positively Regulates T Cell Activation

The Journal of immunology (1950), 2005-05, Vol.174 (9), p.5288-5297

2005

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Systematic identification of regulatory proteins critical for T-cell activation

Journal of biology (London, England), 2003, Vol.2 (3), p.21-21

2003

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A Novel Role for p21-Activated Protein Kinase 2 in T Cell Activation

The Journal of immunology (1950), 2004-06, Vol.172 (12), p.7324-7334

2004

Volltextzugriff (PDF)

Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling

The Journal of experimental medicine, 2001-11, Vol.194 (9), p.1263-1276

2001

Volltextzugriff (PDF)

Abstract LB217: A novel bispecific LILRB4/CD3 antibody with potent killing of monocytic acute myeloid leukemia cells

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (8_Supplement), p.LB217-LB217

2023

Volltextzugriff (PDF)

Abstract CT209: A first-in-human phase 1 trial of IO-108, an antagonist antibody targeting LILRB2 (ILT4), as monotherapy and in combination with pembrolizumab in adult patients with advanced relapsed or refractory solid tumors (NCT05054348)

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.CT209-CT209

2022

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Impaired NFATc Translocation and Failure of Th2 Development in Itk-Deficient CD4 + T Cells

Immunity (Cambridge, Mass.), 1999-10, Vol.11 (4), p.399-409

1999

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Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity

Science (American Association for the Advancement of Science), 1999-04, Vol.284 (5414), p.638-641

1999

Volltextzugriff (PDF)

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk

Immunity (Cambridge, Mass.), 1995-12, Vol.3 (6), p.757-769

1995

Volltextzugriff (PDF)

Antiviral immune responses in Itk-deficient mice

Journal of Virology, 1997-10, Vol.71 (10), p.7253-7257

1997

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Itk negatively regulates induction of T cell proliferation by CD28 costimulation

The Journal of experimental medicine, 1997-07, Vol.186 (2), p.221-228

1997

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Itk and Fyn make independent contributions to T cell activation

The Journal of experimental medicine, 1997-12, Vol.186 (12), p.2069-2073

1997

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Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development

Blocking LAIR1 signaling in immune cells inhibits tumor development

Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor

Phase 1 Randomized, Double-Blind, Placebo-Controlled Study of RG7667, an Anticytomegalovirus Combination Monoclonal Antibody Therapy, in Healthy Adults

304 Antagonistic antibodies targeting LAIR1 enhance T lymphocyte activation and promote inflammatory phenotypes in myeloid cells

LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration

686 Preclinical characterization of a novel therapeutic antibody targeting LILRB2

Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of RG7667, a Combination Monoclonal Antibody, for Prevention of Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients

A randomized trial of the efficacy and safety of quilizumab in adults with inadequately controlled allergic asthma

Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production

Pharmacokinetics and Exposure-Response Analysis of RG7667, a Combination of Two Anticytomegalovirus Monoclonal Antibodies, in a Phase 2a Randomized Trial To Prevent Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients

Racial profiling harms science

Impaired Cytokine Signaling in Mice Lacking the IL-1 Receptor-Associated Kinase

A Novel E3 Ubiquitin Ligase TRAC-1 Positively Regulates T Cell Activation

Systematic identification of regulatory proteins critical for T-cell activation

A Novel Role for p21-Activated Protein Kinase 2 in T Cell Activation

Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling

Abstract LB217: A novel bispecific LILRB4/CD3 antibody with potent killing of monocytic acute myeloid leukemia cells

Abstract CT209: A first-in-human phase 1 trial of IO-108, an antagonist antibody targeting LILRB2 (ILT4), as monotherapy and in combination with pembrolizumab in adult patients with advanced relapsed or refractory solid tumors (NCT05054348)

Impaired NFATc Translocation and Failure of Th2 Development in Itk-Deficient CD4 + T Cells

Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk

Antiviral immune responses in Itk-deficient mice

Itk negatively regulates induction of T cell proliferation by CD28 costimulation

Itk and Fyn make independent contributions to T cell activation

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