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Kibdelomycin Is a Potent and Selective Agent against Toxigenic Clostridium difficile

Antimicrobial agents and chemotherapy, 2014-04, Vol.58 (4), p.2387-2392

2014

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Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6739-6743

2010

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Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core

ACS medicinal chemistry letters, 2010-08, Vol.1 (5), p.214-218

2010

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SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors

Cancer chemotherapy and pharmacology, 2011-10, Vol.68 (4), p.923-933

2011

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TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

Science translational medicine, 2016-03, Vol.8 (329), p.329ra32

2016

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Nocathiacin, Thiazomycin, and Polar Analogs Are Highly Effective Agents against Toxigenic Clostridioides difficile

Journal of natural products (Washington, D.C.), 2022-04, Vol.85 (4), p.1141-1146

2022

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Use of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid Phosphate

Antimicrobial agents and chemotherapy, 2019-01, Vol.63 (1)

2019

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Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates

Journal of medicinal chemistry, 2022-12, Vol.65 (24), p.16234-16251

2022

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SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53

The Journal of biological chemistry, 2010-04, Vol.285 (14), p.10198-10212

2010

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A fully human insulin-like growth factor-I receptor antibody SCH 717454 (Robatumumab) has antitumor activity as a single agent and in combination with cytotoxics in pediatric tumor xenografts

Molecular cancer therapeutics, 2010-02, Vol.9 (2), p.410-418

2010

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Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors

Bioorganic & medicinal chemistry, 2015-05, Vol.23 (10), p.2424-2434

2015

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Discovery of a highly potent orally bioavailable imidazo-[1, 2-a]pyrazine Aurora inhibitor

Bioorganic & medicinal chemistry letters, 2018-05, Vol.28 (8), p.1397-1403

2018

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Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor

Journal of medicinal chemistry, 2017-05, Vol.60 (9), p.3851-3865

2017

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Use of translational PKPD infection models to understand impact of neutropenia on efficacy of tedizolid phosphate

Open forum infectious diseases, 2017-10, Vol.4 (suppl_1), p.S292-S292

2017

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Phosphorylation of CD45 by Casein Kinase 2

The Journal of biological chemistry, 1999-03, Vol.274 (11), p.7454-7461

1999

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SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics

Molecular cancer therapeutics, 2010-11, Vol.9 (11), p.2993-3002

2010

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Phosphorylation of CD45 by casein kinase 2. Modulation of activity and mutational analysis

The Journal of biological chemistry, 1999-03, Vol.274 (11), p.7454-7461

1999

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Discovery of Wall Teichoic Acid Inhibitors as Potential Anti-MRSA β-Lactam Combination Agents

Chemistry & biology, 2013-02, Vol.20 (2), p.272-284

2013

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Regulation of the Calcium/NF-AT T Cell Activation Pathway by the D2 Domain of CD45

The Journal of immunology (1950), 2000-03, Vol.164 (5), p.2557-2564

2000

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Discovery of Novel Wall Teichoic Acid Inhibitors as Effective anti-MRSA β-lactam Combination Agents

Chemistry & biology, 2013-02, Vol.20 (2), p.272-284

2013

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Exploration of green preparation strategy for Lycium barbarum polysaccharide targeting Bacteroides proliferative and immune-enhancing activities and its potential use in geriatric foods

International journal of biological macromolecules, 2024-05, Vol.267 (Pt 1), p.131316-131316, Article 131316

2024

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Influence of NaOH and thermal pretreatment on dewatered activated sludge solubilisation and subsequent anaerobic digestion: Focused on high-solid state

Bioresource technology, 2015-06, Vol.185, p.171-177

2015

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Targeted inactivation of multidrug-resistant Alcaligenes faecalis in pig farm WWTPs by mixed bacteriophages to diminish the risk of pathogenicity and antibiotic resistance dissemination

Process biochemistry (1991), 2024-09, Vol.144, p.187-198

2024

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The influence of calcium hydroxide on the performance of MK-based geopolymer

Construction & building materials, 2022-04, Vol.329, p.127224, Article 127224

2022

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Kibdelomycin Is a Potent and Selective Agent against Toxigenic Clostridium difficile

Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors

Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core

SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

Nocathiacin, Thiazomycin, and Polar Analogs Are Highly Effective Agents against Toxigenic Clostridioides difficile

Use of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid Phosphate

Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics

Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates

SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53

A fully human insulin-like growth factor-I receptor antibody SCH 717454 (Robatumumab) has antitumor activity as a single agent and in combination with cytotoxics in pediatric tumor xenografts

Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors

Discovery of a highly potent orally bioavailable imidazo-[1, 2-a]pyrazine Aurora inhibitor

Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor

Use of translational PKPD infection models to understand impact of neutropenia on efficacy of tedizolid phosphate

Phosphorylation of CD45 by Casein Kinase 2

SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics

Phosphorylation of CD45 by casein kinase 2. Modulation of activity and mutational analysis

Discovery of Wall Teichoic Acid Inhibitors as Potential Anti-MRSA β-Lactam Combination Agents

Regulation of the Calcium/NF-AT T Cell Activation Pathway by the D2 Domain of CD45

Discovery of Novel Wall Teichoic Acid Inhibitors as Effective anti-MRSA β-lactam Combination Agents

Exploration of green preparation strategy for Lycium barbarum polysaccharide targeting Bacteroides proliferative and immune-enhancing activities and its potential use in geriatric foods

Influence of NaOH and thermal pretreatment on dewatered activated sludge solubilisation and subsequent anaerobic digestion: Focused on high-solid state

Targeted inactivation of multidrug-resistant Alcaligenes faecalis in pig farm WWTPs by mixed bacteriophages to diminish the risk of pathogenicity and antibiotic resistance dissemination

The influence of calcium hydroxide on the performance of MK-based geopolymer

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