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Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial

British journal of cancer, 2019-08, Vol.121 (4), p.318-324

2019

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Mild lanthanide(III) catalyzed formation of 4,5-diaminocyclopent-2-enones from 2-furaldehyde and secondary amines: a domino condensation/ring-opening/electrocyclization process

Chemical communications (Cambridge, England), 2007-01 (36), p.3759-3761

2007

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The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3‑(4-(heterocyclyl)phenyl)‑1H‑indazole-5-carboxamides as Anticancer Agents

Journal of medicinal chemistry, 2015-04, Vol.58 (8), p.3366-3392

2015

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A Tandem Prins/Schmidt Reaction Approach to Marine Alkaloids: Formal and Total Syntheses of Lepadiformines A and C

Organic letters, 2010-03, Vol.12 (6), p.1244-1247

2010

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Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides

Bioorganic & medicinal chemistry, 2014-09, Vol.22 (17), p.4968-4997

2014

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Allylation and highly diastereoselective syn or anti crotylation of N-toluenesulfonylimines using potassium allyl- and crotyltrifluoroborates

Chemical communications (Cambridge, England), 2004-06 (12), p.1382-1383

2004

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Overcoming Product Inhibition in Catalysis of the Intramolecular Schmidt Reaction

Journal of the American Chemical Society, 2013-06, Vol.135 (24), p.9000-9009

2013

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The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3H]indol]-2′(1′H)‑ones as Orally Bioavailable Antitumor Agents

Journal of medicinal chemistry, 2015-01, Vol.58 (1), p.130-146

2015

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The Discovery of PLK4 Inhibitors: (E)‑3-((1H‑Indazol-6-yl)methylene)indolin-2-ones as Novel Antiproliferative Agents

Journal of medicinal chemistry, 2013-08, Vol.56 (15), p.6069-6087

2013

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Discovery of Pyrazolo[1,5‑a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent

ACS medicinal chemistry letters, 2016-07, Vol.7 (7), p.671-675

2016

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Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3′-indolin]-2′-ones as potent PLK4 inhibitors with oral antitumor efficacy

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (19), p.4625-4630

2016

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Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK

Bioorganic & medicinal chemistry letters, 2016-08, Vol.26 (15), p.3562-3566

2016

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The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents

Journal of medicinal chemistry, 2015-01, Vol.58 (1), p.130-146

2015

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Organoboron compounds as mild nucleophiles in Lewis acid- and transition metal-catalyzed CC bond-forming reactions

Pure and applied chemistry, 2002-01, Vol.74 (1), p.43-55

2002

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Tracking children’s handwriting learning process using EEG: A system development and validation

Learning and instruction, 2024-04, Vol.90, p.101870, Article 101870

2024

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ChemInform Abstract: Temperature Dependence of Turnover in a Sc(OTf)3-Catalyzed Intramolecular Schmidt Reaction

ChemInform, 2015-10, Vol.46 (41), p.no-no

2015

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Temperature dependence of turnover in a Sc(OTf)3-catalyzed intramolecular Schmidt reaction

Tetrahedron letters, 2015-06, Vol.56 (23), p.3137-3140

2015

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ChemInform Abstract: Overcoming Product Inhibition in Catalysis of the Intramolecular Schmidt Reaction

ChemInform, 2013-11, Vol.44 (46), p.no-no

2013

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ChemInform Abstract: The Schmidt Reaction

ChemInform, 2013-08, Vol.44 (32), p.no-no

2013

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ChemInform Abstract: Mild Lanthanide(III)-Catalyzed Formation of 4,5-Diaminocyclopent-2-enones from 2-Furaldehyde and Secondary Amines: A Domino Condensation/Ring-Opening/Electrocyclization Process

ChemInform, 2008-01, Vol.39 (4), p.no-no

2008

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ChemInform Abstract: A Tandem Prins/Schmidt Reaction Approach to Marine Alkaloids: Formal and Total Syntheses of Lepadiformines A (XVI) and C (XVII)

ChemInform, 2010-08, Vol.41 (31), p.no-no

2010

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The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1 H -indazole-5-carboxamides as Anticancer Agents

Journal of medicinal chemistry, 2015-04, Vol.58 (8), p.3366-3392

2015

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Allylation and Highly Diastereoselective syn or anti Crotylation of N-Toluenesulfonylimines Using Potassium Allyl- and Crotyltrifluoroborates

ChemInform, 2004-10, Vol.35 (42), p.no-no

2004

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Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial

Mild lanthanide(III) catalyzed formation of 4,5-diaminocyclopent-2-enones from 2-furaldehyde and secondary amines: a domino condensation/ring-opening/electrocyclization process

The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3‑(4-(heterocyclyl)phenyl)‑1H‑indazole-5-carboxamides as Anticancer Agents

A Tandem Prins/Schmidt Reaction Approach to Marine Alkaloids: Formal and Total Syntheses of Lepadiformines A and C

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides

The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1 R ,2 S )-2-(3-(( E )-4-((( cis )-2,6-Dimethylmorpholino)methyl)styryl)-1 H -indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

Allylation and highly diastereoselective syn or anti crotylation of N-toluenesulfonylimines using potassium allyl- and crotyltrifluoroborates

Overcoming Product Inhibition in Catalysis of the Intramolecular Schmidt Reaction

The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3H]indol]-2′(1′H)‑ones as Orally Bioavailable Antitumor Agents

The Discovery of PLK4 Inhibitors: (E)‑3-((1H‑Indazol-6-yl)methylene)indolin-2-ones as Novel Antiproliferative Agents

Discovery of Pyrazolo[1,5‑a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent

Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3′-indolin]-2′-ones as potent PLK4 inhibitors with oral antitumor efficacy

Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK

The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents

Organoboron compounds as mild nucleophiles in Lewis acid- and transition metal-catalyzed CC bond-forming reactions

Tracking children’s handwriting learning process using EEG: A system development and validation

The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)‑2-(3-((E)‑4-(((cis)‑2,6-Dimethylmorpholino)methyl)styryl)‑1H‑indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

ChemInform Abstract: Temperature Dependence of Turnover in a Sc(OTf)3-Catalyzed Intramolecular Schmidt Reaction

Temperature dependence of turnover in a Sc(OTf)3-catalyzed intramolecular Schmidt reaction

ChemInform Abstract: Overcoming Product Inhibition in Catalysis of the Intramolecular Schmidt Reaction

ChemInform Abstract: The Schmidt Reaction

ChemInform Abstract: Mild Lanthanide(III)-Catalyzed Formation of 4,5-Diaminocyclopent-2-enones from 2-Furaldehyde and Secondary Amines: A Domino Condensation/Ring-Opening/Electrocyclization Process

ChemInform Abstract: A Tandem Prins/Schmidt Reaction Approach to Marine Alkaloids: Formal and Total Syntheses of Lepadiformines A (XVI) and C (XVII)

The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1 H -indazole-5-carboxamides as Anticancer Agents

Allylation and Highly Diastereoselective syn or anti Crotylation of N-Toluenesulfonylimines Using Potassium Allyl- and Crotyltrifluoroborates

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