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Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs

Gene, 2015-10, Vol.571 (2), p.153-166

2015

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Solution Structure of Human Cardiac Troponin C in Complex with the Green Tea Polyphenol, (−)-Epigallocatechin 3-Gallate

The Journal of biological chemistry, 2009-08, Vol.284 (34), p.23012-23023

2009

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Structural Basis of Tirasemtiv Activation of Fast Skeletal Muscle

Journal of medicinal chemistry, 2021-03, Vol.64 (6), p.3026-3034

2021

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The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C

Biochemistry and biophysics reports, 2018-12, Vol.16, p.145-151

2018

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Binding of Cardiac Troponin-I147-163 Induces a Structural Opening in Human Cardiac Troponin-C

Biochemistry (Easton), 1999-06, Vol.38 (26), p.8289-8298

1999

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Structures reveal details of small molecule binding to cardiac troponin

Journal of molecular and cellular cardiology, 2016-12, Vol.101, p.134-144

2016

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The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29Q

Journal of molecular and cellular cardiology, 2015-10, Vol.87, p.257-269

2015

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A structural and functional perspective into the mechanism of Ca2+ -sensitizers that target the cardiac troponin complex

Journal of molecular and cellular cardiology, 2010-12, Vol.49 (6), p.1031-1041

2010

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Structures of the troponin C regulatory domains in the apo and calcium-saturated states

Nature structural & molecular biology, 1995-09, Vol.2 (9), p.784-789

1995

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3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP

The Journal of general physiology, 2019-01, Vol.151 (1), p.9-17

2019

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Computer-Aided Drug Discovery Approach Finds Calcium Sensitizer of Cardiac Troponin

Chemical biology & drug design, 2015-02, Vol.85 (2), p.99-106

2015

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Structural and Functional Consequences of the Cardiac Troponin C L48Q Ca2+-Sensitizing Mutation

Biochemistry (Easton), 2012-06, Vol.51 (22), p.4473-4487

2012

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Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation

Biochemistry (Easton), 2012-06, Vol.51 (22), p.4473-4487

2012

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Solution structure of the regulatory domain of human cardiac troponin C in complex with the switch region of cardiac troponin I and W7: The basis of W7 as an inhibitor of cardiac muscle contraction

Journal of molecular and cellular cardiology, 2010-05, Vol.48 (5), p.925-933

2010

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Interaction between the regulatory domain of cardiac troponin C and the acidosis-resistant cardiac troponin I A162H

Cardiovascular research, 2013-03, Vol.97 (3), p.481-489

2013

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Modulation of Cardiac Troponin C Function by the Cardiac-Specific N-Terminus of Troponin I: Influence of PKA Phosphorylation and Involvement in Cardiomyopathies

Journal of molecular biology, 2008-01, Vol.375 (3), p.735-751

2008

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Calcium-Induced Structural Transition in the Regulatory Domain of Human Cardiac Troponin C

Biochemistry (Easton), 1997-10, Vol.36 (40), p.12138-12146

1997

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Interaction of cardiac troponin with cardiotonic drugs: A structural perspective

Biochemical and biophysical research communications, 2008-04, Vol.369 (1), p.88-99

2008

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Elucidation of Isoform-dependent pH Sensitivity of Troponin I by NMR Spectroscopy

The Journal of biological chemistry, 2012-02, Vol.287 (7), p.4996-5007

2012

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Structural based insights into the role of troponin in cardiac muscle pathophysiology

Journal of muscle research and cell motility, 2004-01, Vol.25 (7), p.559-579

2004

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Defining the Binding Site of Levosimendan and Its Analogues in a Regulatory Cardiac Troponin C−Troponin I Complex

Biochemistry (Easton), 2008-07, Vol.47 (28), p.7485-7495

2008

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Mechanism of Direct Coupling between Binding and Induced Structural Change in Regulatory Calcium Binding Proteins

Biochemistry (Easton), 1997-04, Vol.36 (15), p.4386-4392

1997

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Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil

The Journal of biological chemistry, 2002-08, Vol.277 (34), p.31124-31133

2002

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Structure of Cardiac Muscle Troponin C Unexpectedly Reveals a Closed Regulatory Domain

The Journal of biological chemistry, 1997-07, Vol.272 (29), p.18216-18221

1997

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Structure of the C-domain of Human Cardiac Troponin C in Complex with the Ca2+ Sensitizing Drug EMD 57033

The Journal of biological chemistry, 2001-07, Vol.276 (27), p.25456-25466

2001

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Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs

Solution Structure of Human Cardiac Troponin C in Complex with the Green Tea Polyphenol, (−)-Epigallocatechin 3-Gallate

Structural Basis of Tirasemtiv Activation of Fast Skeletal Muscle

The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C

Binding of Cardiac Troponin-I147-163 Induces a Structural Opening in Human Cardiac Troponin-C

Structures reveal details of small molecule binding to cardiac troponin

The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29Q

A structural and functional perspective into the mechanism of Ca2+ -sensitizers that target the cardiac troponin complex

Structures of the troponin C regulatory domains in the apo and calcium-saturated states

3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP

Computer-Aided Drug Discovery Approach Finds Calcium Sensitizer of Cardiac Troponin

Structural and Functional Consequences of the Cardiac Troponin C L48Q Ca2+-Sensitizing Mutation

Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation

Solution structure of the regulatory domain of human cardiac troponin C in complex with the switch region of cardiac troponin I and W7: The basis of W7 as an inhibitor of cardiac muscle contraction

Interaction between the regulatory domain of cardiac troponin C and the acidosis-resistant cardiac troponin I A162H

Modulation of Cardiac Troponin C Function by the Cardiac-Specific N-Terminus of Troponin I: Influence of PKA Phosphorylation and Involvement in Cardiomyopathies

Calcium-Induced Structural Transition in the Regulatory Domain of Human Cardiac Troponin C

Interaction of cardiac troponin with cardiotonic drugs: A structural perspective

Elucidation of Isoform-dependent pH Sensitivity of Troponin I by NMR Spectroscopy

Structural based insights into the role of troponin in cardiac muscle pathophysiology

Defining the Binding Site of Levosimendan and Its Analogues in a Regulatory Cardiac Troponin C−Troponin I Complex

Mechanism of Direct Coupling between Binding and Induced Structural Change in Regulatory Calcium Binding Proteins

Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil

Structure of Cardiac Muscle Troponin C Unexpectedly Reveals a Closed Regulatory Domain

Structure of the C-domain of Human Cardiac Troponin C in Complex with the Ca2+ Sensitizing Drug EMD 57033

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