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Host microbiome depletion attenuates biofluid metabolite responses following radiation exposure

PloS one, 2024-05, Vol.19 (5), p.e0300883-e0300883

2024

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Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells

Environmental and molecular mutagenesis, 2015-07, Vol.56 (6), p.505-519

2015

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Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs

Proceedings of the National Academy of Sciences - PNAS, 2017-12, Vol.114 (51), p.E10881-E10889

2017

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Assessment of the performance of the TGx‐DDI biomarker to detect DNA damage‐inducing agents using quantitative RT‐PCR in TK6 cells

Environmental and molecular mutagenesis, 2019-03, Vol.60 (2), p.122-133

2019

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Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells

Archives of toxicology, 2021-05, Vol.95 (5), p.1631-1645

2021

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Application of the adverse outcome pathway framework to genotoxic modes of action

Environmental and molecular mutagenesis, 2020-01, Vol.61 (1), p.114-134

2020

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Metabolomic alterations associated with Behçet's disease

Arthritis research & therapy, 2018-09, Vol.20 (1), p.214-214, Article 214

2018

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Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function

Scientific reports, 2016-07, Vol.6 (1), p.28994-28994, Article 28994

2016

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A specific PP2A regulatory subunit, B56γ, mediates DNA damage-induced dephosphorylation of p53 at Thr55

The EMBO journal, 2007-01, Vol.26 (2), p.402-411

2007

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Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9

Environmental and molecular mutagenesis, 2016-05, Vol.57 (4), p.243-260

2016

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Modulation of Fatty Acid and Bile Acid Metabolism By Peroxisome Proliferator-Activated Receptor α Protects Against Alcoholic Liver Disease

Alcoholism, clinical and experimental research, 2014-06, Vol.38 (6), p.1520-1531

2014

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A high-throughput and highly automated genotoxicity screening assay

ALTEX, alternatives to animal experimentation, 2022, Vol.39 (1), p.71-81

2022

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Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells

Environmental and molecular mutagenesis, 2015-07, Vol.56 (6), p.520-534

2015

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Oral N-acetylcysteine decreases IFN-γ production and ameliorates ischemia-reperfusion injury in steatotic livers

Frontiers in immunology, 2022-09, Vol.13, p.898799-898799

2022

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Serum Metabolomic Alterations Associated with Cesium-137 Internal Emitter Delivered in Various Dose Rates

Metabolites, 2020-06, Vol.10 (7), p.270

2020

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Circulating cell-free methylated DNA reveals tissue-specific, cellular damage from radiation treatment

JCI insight, 2023-07, Vol.8 (14)

2023

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Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip ® assay in TK6 cells

Frontiers in toxicology, 2022-09, Vol.4, p.991590

2022

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3,3'-Diindolylmethane Enhances Tumor Regression After Radiation Through Protecting Normal Cells to Modulate Antitumor Immunity

Advances in radiation oncology, 2021-01, Vol.6 (1), p.100601, Article 100601

2021

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Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease

Journal of translational medicine, 2013-10, Vol.11 (1), p.266-266, Article 266

2013

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Editorial: Biomarkers of Immune-Checkpoint-Inhibitor Immunotherapies in Hepatocellular Carcinomas

Frontiers in oncology, 2022-03, Vol.12, p.860964-860964

2022

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An Integrated Multi-Omic Approach to Assess Radiation Injury on the Host-Microbiome Axis

Radiation research, 2016-09, Vol.186 (3), p.219

2016

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Prior irradiation results in elevated programmed cell death protein 1 (PD-1) in T cells

International journal of radiation biology, 2018-04, Vol.94 (5), p.488-494

2018

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Radiochemotherapy upregulates expression of checkpoint receptors on circulating T cells

International journal of radiation biology, 2021-11, Vol.97 (11), p.1563-1568

2021

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Small Molecule Signatures of Mice Lacking T-cell p38 Alternate Activation, a Model for Immunosuppression Conditions, after Total-Body Irradiation

Radiation research, 2022-06, Vol.197 (6), p.613

2022

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A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells

Data in brief, 2015-12, Vol.5 (C), p.77-83

2015

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Host microbiome depletion attenuates biofluid metabolite responses following radiation exposure

Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells

Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs

Assessment of the performance of the TGx‐DDI biomarker to detect DNA damage‐inducing agents using quantitative RT‐PCR in TK6 cells

Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells

Application of the adverse outcome pathway framework to genotoxic modes of action

Metabolomic alterations associated with Behçet's disease

Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function

A specific PP2A regulatory subunit, B56γ, mediates DNA damage-induced dephosphorylation of p53 at Thr55

Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9

Modulation of Fatty Acid and Bile Acid Metabolism By Peroxisome Proliferator-Activated Receptor α Protects Against Alcoholic Liver Disease

A high-throughput and highly automated genotoxicity screening assay

Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells

Oral N-acetylcysteine decreases IFN-γ production and ameliorates ischemia-reperfusion injury in steatotic livers

Serum Metabolomic Alterations Associated with Cesium-137 Internal Emitter Delivered in Various Dose Rates

Circulating cell-free methylated DNA reveals tissue-specific, cellular damage from radiation treatment

Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip ® assay in TK6 cells

3,3'-Diindolylmethane Enhances Tumor Regression After Radiation Through Protecting Normal Cells to Modulate Antitumor Immunity

Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease

Editorial: Biomarkers of Immune-Checkpoint-Inhibitor Immunotherapies in Hepatocellular Carcinomas

An Integrated Multi-Omic Approach to Assess Radiation Injury on the Host-Microbiome Axis

Prior irradiation results in elevated programmed cell death protein 1 (PD-1) in T cells

Radiochemotherapy upregulates expression of checkpoint receptors on circulating T cells

Small Molecule Signatures of Mice Lacking T-cell p38 Alternate Activation, a Model for Immunosuppression Conditions, after Total-Body Irradiation

A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells

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