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Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (21), p.4741-4744

2005

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Rapid measurement of deuterium-labeled long-chain fatty acids in plasma by HPLC-ESI-MS

Journal of lipid research, 2007-01, Vol.48 (1), p.252-259

2007

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Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.499-502

2010

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Thiazole analog as stearoyl-CoA desaturase 1 inhibitor

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5214-5217

2009

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SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1593-1597

2010

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The identification of potent, selective, and bioavailable cathepsin S inhibitors

Bioorganic & medicinal chemistry letters, 2007-09, Vol.17 (17), p.4929-4933

2007

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Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitors

Journal of lipid research, 2011-08, Vol.52 (8), p.1494-1499

2011

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Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: From systemic to liver-targeting inhibitors

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (19), p.5692-5696

2011

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Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.623-627

2012

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Identification of a potent and selective non-basic cathepsin K inhibitor

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1985-1989

2006

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Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (21), p.6505-6509

2011

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Cyclooxygenase-2 Inhibitors. Synthesis and Pharmacological Activities of 5-Methanesulfonamido-1-indanone Derivatives

Journal of medicinal chemistry, 1995-12, Vol.38 (25), p.4897-4905

1995

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Difluoroethylamines as an amide isostere in inhibitors of cathepsin K

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (3), p.920-923

2011

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Synthesis of pyran-4-ones from isoxazoles

Tetrahedron letters, 2002-05, Vol.43 (19), p.3565-3568

2002

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Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (4), p.1043-1048

2004

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Pyridazinones as selective cyclooxygenase-2 inhibitors

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (4), p.597-600

2003

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Differential effects of inosine monophosphate dehydrogenase (IMPDH/GuaB) inhibition in Acinetobacter baumannii and Escherichia coli

Journal of bacteriology, 2024-09

2024

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Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (4), p.126907, Article 126907

2020

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3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1195-1198

2003

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Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1201-1203

2004

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Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors

Bioorganic & medicinal chemistry letters, 1999-11, Vol.9 (22), p.3187-3192

1999

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Synthesis of an [125I]-labelled derivative of MK-571, a tool for LTD4 receptor studies

Journal of labelled compounds & radiopharmaceuticals, 1994-06, Vol.34 (6), p.537-544

1994

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Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K

Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity

Rapid measurement of deuterium-labeled long-chain fatty acids in plasma by HPLC-ESI-MS

Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)

Thiazole analog as stearoyl-CoA desaturase 1 inhibitor

SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors

The identification of potent, selective, and bioavailable cathepsin S inhibitors

Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitors

Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: From systemic to liver-targeting inhibitors

Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series

Identification of a potent and selective non-basic cathepsin K inhibitor

Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors

Cyclooxygenase-2 Inhibitors. Synthesis and Pharmacological Activities of 5-Methanesulfonamido-1-indanone Derivatives

Difluoroethylamines as an amide isostere in inhibitors of cathepsin K

Synthesis of pyran-4-ones from isoxazoles

Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors

Pyridazinones as selective cyclooxygenase-2 inhibitors

Differential effects of inosine monophosphate dehydrogenase (IMPDH/GuaB) inhibition in Acinetobacter baumannii and Escherichia coli

Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)

Discovery of GuaB inhibitors with efficacy against Acinetobacter baumannii infection

3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility

Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2

Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors

Front Cover: Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity (ChemMedChem 1/2020)

Synthesis of an [125I]-labelled derivative of MK-571, a tool for LTD4 receptor studies

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