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Targeted Molecular Therapeutics for Bladder Cancer-A New Option beyond the Mixed Fortunes of Immune Checkpoint Inhibitors?

International journal of molecular sciences, 2020-10, Vol.21 (19), p.7268

2020

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Impact of Endocytosis Mechanisms for the Receptors Targeted by the Currently Approved Antibody-Drug Conjugates (ADCs)—A Necessity for Future ADC Research and Development

Pharmaceuticals (Basel, Switzerland), 2021-07, Vol.14 (7), p.674

2021

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Improving Receptor-Mediated Intracellular Access and Accumulation of Antibody Therapeutics—The Tale of HER2

Antibodies (Basel), 2020-07, Vol.9 (3), p.32

Leyton, Jeffrey

2020

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CD16 + NK-92 and anti-CD123 monoclonal antibody prolongs survival in primary human acute myeloid leukemia xenografted mice

Haematologica (Roma), 2018-10, Vol.103 (10), p.1720-1729

2018

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A Novel Proteomic Method Reveals NLS Tagging of T-DM1 Contravenes Classical Nuclear Transport in a Model of HER2-Positive Breast Cancer

Molecular therapy. Methods & clinical development, 2020-12, Vol.19, p.99-119

2020

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The endosomal-lysosomal system in ADC design and cancer therapy

Expert opinion on biological therapy, 2023-11, Vol.23 (11), p.1067-1076

Leyton, Jeffrey V

2023

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Solution-Phase Surface Modification in Intact Poly(dimethylsiloxane) Microfluidic Channels

Analytical chemistry (Washington), 2006-08, Vol.78 (15), p.5543-5551

2006

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A preclinical PET dual-tracer imaging protocol for ER and HER2 phenotyping in breast cancer xenografts

EJNMMI research, 2020-07, Vol.10 (1), p.69-69, Article 69

2020

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Humanized Radioiodinated Minibody For Imaging of Prostate Stem Cell Antigen–Expressing Tumors

Clinical cancer research, 2008-11, Vol.14 (22), p.7488-7496

2008

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Nuclear localization signal-tagged systems: relevant nuclear import principles in the context of current therapeutic design

Chemical Society reviews, 2024-01, Vol.53 (1), p.24-226

2024

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An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors

European journal of nuclear medicine and molecular imaging, 2010-08, Vol.37 (8), p.1529-1538

2010

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Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer

Oncoimmunology, 2017-10, Vol.6 (10), p.e1331195-e1331195

2017

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A radiolabeled antibody targeting CD123+ leukemia stem cells – initial radioimmunotherapy studies in NOD/SCID mice engrafted with primary human AML

Leukemia research reports, 2015, Vol.4 (2), p.55-59

2015

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Antibody Therapies for Acute Myeloid Leukemia: Unconjugated, Toxin-Conjugated, Radio-Conjugated and Multivalent Formats

Journal of clinical medicine, 2019-08, Vol.8 (8), p.1261

2019

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Development of a Novel Covalent Folate-Albumin-Photosensitizer Conjugate

Photochemistry and photobiology, 2016-07, Vol.92 (4), p.512-514

2016

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Positron Emission Tomographic Imaging of Iodine 124 Anti–Prostate Stem Cell Antigen–Engineered Antibody Fragments in LAPC-9 Tumor–Bearing Severe Combined Immunodeficiency Mice

Molecular imaging, 2013-05, Vol.12 (3), p.191-202

2013

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BODIPY-17α-ethynylestradiol conjugates: Synthesis, fluorescence properties and receptor binding affinities

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (3), p.443-446

2017

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NLS-Cholic Acid Conjugation to IL-5Rα-Specific Antibody Improves Cellular Accumulation and In Vivo Tumor-Targeting Properties in a Bladder Cancer Model

Bioconjugate chemistry, 2018-04, Vol.29 (4), p.1352-1363

2018

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In-Bn-DTPA-nimotuzumab with/without modification with nuclear translocation sequence (NLS) peptides: an Auger electron-emitting radioimmunotherapeutic agent for EGFR-positive and trastuzumab (Herceptin)-resistant breast cancer

Breast cancer research and treatment, 2012-08, Vol.135 (1), p.189-200

2012

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ChAcNLS, a Novel Modification to Antibody-Conjugates Permitting Target Cell-Specific Endosomal Escape, Localization to the Nucleus, and Enhanced Total Intracellular Accumulation

Molecular pharmaceutics, 2016-06, Vol.13 (6), p.1915-1926

2016

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Paradoxical effects of Auger electron-emitting (111)In-DTPA-NLS-CSL360 radioimmunoconjugates on hCD45(+) cells in the bone marrow and spleen of leukemia-engrafted NOD/SCID or NRG mice

Nuclear medicine and biology, 2016-10, Vol.43 (10), p.635

2016

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Auger electron-emitting (111)In-DTPA-NLS-CSL360 radioimmunoconjugates are cytotoxic to human acute myeloid leukemia (AML) cells displaying the CD123(+)/CD131(-) phenotype of leukemia stem cells

Applied radiation and isotopes, 2016-04, Vol.110, p.1-7

2016

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Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Journal of visualized experiments, 2018-03 (133)

2018

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MicroSPECT/CT imaging of primary human AML engrafted into the bone marrow and spleen of NOD/SCID mice using 111In-DTPA-NLS-CSL360 radioimmunoconjugates recognizing the CD123+/CD131− epitope expressed by leukemia stem cells

Leukemia research, 2014-11, Vol.38 (11), p.1367-1373

2014

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The human polynucleotide kinase/phosphatase (hPNKP) inhibitor A12B4C3 radiosensitizes human myeloid leukemia cells to Auger electron-emitting anti-CD123 111In-NLS-7G3 radioimmunoconjugates

Nuclear medicine and biology, 2014-05, Vol.41 (5), p.377-383

2014

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Targeted Molecular Therapeutics for Bladder Cancer-A New Option beyond the Mixed Fortunes of Immune Checkpoint Inhibitors?

Impact of Endocytosis Mechanisms for the Receptors Targeted by the Currently Approved Antibody-Drug Conjugates (ADCs)—A Necessity for Future ADC Research and Development

Improving Receptor-Mediated Intracellular Access and Accumulation of Antibody Therapeutics—The Tale of HER2

CD16 + NK-92 and anti-CD123 monoclonal antibody prolongs survival in primary human acute myeloid leukemia xenografted mice

A Novel Proteomic Method Reveals NLS Tagging of T-DM1 Contravenes Classical Nuclear Transport in a Model of HER2-Positive Breast Cancer

The endosomal-lysosomal system in ADC design and cancer therapy

Solution-Phase Surface Modification in Intact Poly(dimethylsiloxane) Microfluidic Channels

A preclinical PET dual-tracer imaging protocol for ER and HER2 phenotyping in breast cancer xenografts

Humanized Radioiodinated Minibody For Imaging of Prostate Stem Cell Antigen–Expressing Tumors

Nuclear localization signal-tagged systems: relevant nuclear import principles in the context of current therapeutic design

An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors

Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer

A radiolabeled antibody targeting CD123+ leukemia stem cells – initial radioimmunotherapy studies in NOD/SCID mice engrafted with primary human AML

Antibody Therapies for Acute Myeloid Leukemia: Unconjugated, Toxin-Conjugated, Radio-Conjugated and Multivalent Formats

Development of a Novel Covalent Folate-Albumin-Photosensitizer Conjugate

Positron Emission Tomographic Imaging of Iodine 124 Anti–Prostate Stem Cell Antigen–Engineered Antibody Fragments in LAPC-9 Tumor–Bearing Severe Combined Immunodeficiency Mice

BODIPY-17α-ethynylestradiol conjugates: Synthesis, fluorescence properties and receptor binding affinities

NLS-Cholic Acid Conjugation to IL-5Rα-Specific Antibody Improves Cellular Accumulation and In Vivo Tumor-Targeting Properties in a Bladder Cancer Model

In-Bn-DTPA-nimotuzumab with/without modification with nuclear translocation sequence (NLS) peptides: an Auger electron-emitting radioimmunotherapeutic agent for EGFR-positive and trastuzumab (Herceptin)-resistant breast cancer

ChAcNLS, a Novel Modification to Antibody-Conjugates Permitting Target Cell-Specific Endosomal Escape, Localization to the Nucleus, and Enhanced Total Intracellular Accumulation

Paradoxical effects of Auger electron-emitting (111)In-DTPA-NLS-CSL360 radioimmunoconjugates on hCD45(+) cells in the bone marrow and spleen of leukemia-engrafted NOD/SCID or NRG mice

Auger electron-emitting (111)In-DTPA-NLS-CSL360 radioimmunoconjugates are cytotoxic to human acute myeloid leukemia (AML) cells displaying the CD123(+)/CD131(-) phenotype of leukemia stem cells

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

MicroSPECT/CT imaging of primary human AML engrafted into the bone marrow and spleen of NOD/SCID mice using 111In-DTPA-NLS-CSL360 radioimmunoconjugates recognizing the CD123+/CD131− epitope expressed by leukemia stem cells

The human polynucleotide kinase/phosphatase (hPNKP) inhibitor A12B4C3 radiosensitizes human myeloid leukemia cells to Auger electron-emitting anti-CD123 111In-NLS-7G3 radioimmunoconjugates

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