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Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors

Redox biology, 2019-06, Vol.24, p.101201-101201, Article 101201

2019

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SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19

Frontiers in immunology, 2020-10, Vol.11, p.582102-582102

2020

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Gene Therapy for Rhodopsin Mutations

Cold Spring Harbor perspectives in biology, 2022-09, Vol.14 (9), p.1

2022

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Daily zeaxanthin supplementation prevents atrophy of the retinal pigment epithelium (RPE) in a mouse model of mitochondrial oxidative stress

PloS one, 2018-09, Vol.13 (9), p.e0203816-e0203816

2018

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Corneal application of SOCS1/3 peptides for the treatment of eye diseases mediated by inflammation and oxidative stress

Frontiers in immunology, 2024-07, Vol.15, p.1416181

2024

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Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy

PloS one, 2017-02, Vol.12 (2), p.e0171940

2017

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High-efficiency Transduction of the Mouse Retina by Tyrosine-mutant AAV Serotype Vectors

Molecular therapy, 2009-03, Vol.17 (3), p.463-471

2009

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Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber’s hereditary optic neuropathy in a mouse model

Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (20), p.E1238-E1247

2012

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Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

Proceedings of the National Academy of Sciences - PNAS, 2010-03, Vol.107 (13), p.5961-5966

2010

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ACE2 and Ang-(1-7) Confer Protection Against Development of Diabetic Retinopathy

Molecular therapy, 2012-01, Vol.20 (1), p.28-36

2012

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Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa

Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (6), p.2132-2137

2012

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Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease

Proceedings of the National Academy of Sciences - PNAS, 2015-10, Vol.112 (43), p.E5844-E5853

2015

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Ablation of C/EBP homologous protein does not protect T17M RHO mice from retinal degeneration

PloS one, 2013-04, Vol.8 (4), p.e63205-e63205

2013

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A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis

PloS one, 2020-02, Vol.15 (2), p.e0227524-e0227524

2020

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Sectoral activation of glia in an inducible mouse model of autosomal dominant retinitis pigmentosa

Scientific reports, 2020-10, Vol.10 (1), p.16967-16967, Article 16967

2020

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Characterization of a transgenic short hairpin RNA-induced murine model of Tafazzin deficiency

Human gene therapy, 2011-07, Vol.22 (7), p.865-871

2011

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Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice

Molecular therapy, 2005-10, Vol.12 (4), p.618-633

2005

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Systemic Injection of RPE65-Programmed Bone Marrow-Derived Cells Prevents Progression of Chronic Retinal Degeneration

Molecular therapy, 2017-04, Vol.25 (4), p.917-927

2017

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Buspirone Enhances Cell Survival and Preserves Structural Integrity during Oxidative Injury to the Retinal Pigment Epithelium

Antioxidants, 2023-12, Vol.12 (12), p.2129

2023

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Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice

Proceedings of the National Academy of Sciences - PNAS, 2015-10, Vol.112 (42), p.E5689-E5698

2015

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Suppression of Mitochondrial Oxidative Stress Provides Long-term Neuroprotection in Experimental Optic Neuritis

Investigative ophthalmology & visual science, 2007-02, Vol.48 (2), p.681-691

2007

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Delivery of CR2-fH Using AAV Vector Therapy as Treatment Strategy in the Mouse Model of Choroidal Neovascularization

Molecular therapy. Methods & clinical development, 2018-06, Vol.9, p.1-11

2018

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The Importance of Mitochondria in Age-Related and Inherited Eye Disorders

Ophthalmic research, 2010-01, Vol.44 (3), p.179-190

2010

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Erythropoietin Slows Photoreceptor Cell Death in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

PloS one, 2016-06, Vol.11 (6), p.e0157411

2016

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Amelioration of Leigh syndrome induced by mouse blastocyst complementation with a mutant human mitochondrial ATP synthase 6

Clinical and translational discovery, 2022-09, Vol.2 (3), p.n/a

2022

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Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors

SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19

Gene Therapy for Rhodopsin Mutations

Daily zeaxanthin supplementation prevents atrophy of the retinal pigment epithelium (RPE) in a mouse model of mitochondrial oxidative stress

Corneal application of SOCS1/3 peptides for the treatment of eye diseases mediated by inflammation and oxidative stress

Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy

High-efficiency Transduction of the Mouse Retina by Tyrosine-mutant AAV Serotype Vectors

Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber’s hereditary optic neuropathy in a mouse model

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

ACE2 and Ang-(1-7) Confer Protection Against Development of Diabetic Retinopathy

Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa

Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease

Ablation of C/EBP homologous protein does not protect T17M RHO mice from retinal degeneration

A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis

Sectoral activation of glia in an inducible mouse model of autosomal dominant retinitis pigmentosa

Characterization of a transgenic short hairpin RNA-induced murine model of Tafazzin deficiency

Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice

Systemic Injection of RPE65-Programmed Bone Marrow-Derived Cells Prevents Progression of Chronic Retinal Degeneration

Buspirone Enhances Cell Survival and Preserves Structural Integrity during Oxidative Injury to the Retinal Pigment Epithelium

Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice

Suppression of Mitochondrial Oxidative Stress Provides Long-term Neuroprotection in Experimental Optic Neuritis

Delivery of CR2-fH Using AAV Vector Therapy as Treatment Strategy in the Mouse Model of Choroidal Neovascularization

The Importance of Mitochondria in Age-Related and Inherited Eye Disorders

Erythropoietin Slows Photoreceptor Cell Death in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

Amelioration of Leigh syndrome induced by mouse blastocyst complementation with a mutant human mitochondrial ATP synthase 6

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