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High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations

Proceedings of the National Academy of Sciences - PNAS, 2008-02, Vol.105 (5), p.1466-1471

2008

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The pregnancy and long-term neurodevelopmental outcome of monochorionic diamniotic twin gestations: a multicenter prospective cohort study from the first trimester onward

American journal of obstetrics and gynecology, 2009-05, Vol.200 (5), p.494.e1-494.e8

2009

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Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors

Progress in biophysics and molecular biology, 2005-06, Vol.88 (2), p.209-231

2005

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Concentration and pH Dependent Aggregation of Hydrophobic Drug Molecules and Relevance to Oral Bioavailability

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.1974-1983

2005

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SYNOPSIS: SYNthesize and OPtimize System in Silico

Journal of medicinal chemistry, 2003-06, Vol.46 (13), p.2765-2773

2003

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Novel triazine dimers with potent antitrypanosomal activity

European journal of medicinal chemistry, 2018-01, Vol.143, p.306-319

2018

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Development and in vitro evaluation of a vaginal microbicide gel formulation for UAMC01398, a novel diaryltriazine NNRTI against HIV-1

Antiviral research, 2014-01, Vol.101, p.113-121

2014

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From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds

Bioorganic & medicinal chemistry, 2014-10, Vol.22 (19), p.5241-5248

2014

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Synthesis of Novel Diarylpyrimidine Analogues and Their Antiviral Activity against Human Immunodeficiency Virus Type 1

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.2072-2079

2005

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The conductor and his orchestra

Drug discovery today, 2008-04, Vol.13 (7), p.281-284

Lewi, Paul J.

2008

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Diaryltriazine non-nucleoside reverse transcriptase inhibitors are potent candidates for pre-exposure prophylaxis in the prevention of sexual HIV transmission

Journal of antimicrobial chemotherapy, 2013-09, Vol.68 (9), p.2038-2047

2013

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Stereotypy in schizophrenia

Schizophrenia research, 2006-06, Vol.84 (2), p.397-404

2006

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Synthesis, evaluation and structure–activity relationships of triazine dimers as novel antiviral agents

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (23), p.7174-7178

2012

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Evolution of anti-HIV drug candidates. Part 3: diarylpyrimidine (DAPY) analogues

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (17), p.2235-2239

2001

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Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs)

Bioorganic & medicinal chemistry, 2011-10, Vol.19 (20), p.5924-5934

2011

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Successful pharmaceutical discovery: Paul Janssen's concept of drug research

R & D management, 2007-09, Vol.37 (4), p.355-362

2007

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Evolution of anti-HIV drug candidates. Part 2 : Diaryltriazine (DATA) analogues

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (17), p.2229-2234

2001

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Graphical Exploration of Gene Expression Data: A Comparative Study of Three Multivariate Methods

Biometrics, 2003-12, Vol.59 (4), p.1131-1139

2003

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Design, Synthesis, and SAR of a Novel Pyrazinone Series with Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitory Activity

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.1910-1918

2005

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Preterm rabbit lung tissue mechanics: Maturational changes and effect of antenatal steroids

Pediatric pulmonology, 2010-04, Vol.45 (4), p.349-355

2010

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The effect of maternal betamethasone and fetal tracheal occlusion on pulmonary vascular morphometry in fetal rabbits with surgically induced diaphragmatic hernia: a placebo controlled morphologic study

Prenatal diagnosis, 2009-07, Vol.29 (7), p.674-681

2009

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The role of statistics in the success of a pharmaceutical research laboratory: A historical case description

Journal of chemometrics, 2005-05, Vol.19 (5-7), p.282-287

Lewi, Paul J.

2005

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Structure Based Activity Prediction of HIV-1 Reverse Transcriptase Inhibitors

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.2176-2183

2005

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High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations

The pregnancy and long-term neurodevelopmental outcome of monochorionic diamniotic twin gestations: a multicenter prospective cohort study from the first trimester onward

Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors

In Search of a Novel Anti-HIV Drug: Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, Rilpivirine)

Concentration and pH Dependent Aggregation of Hydrophobic Drug Molecules and Relevance to Oral Bioavailability

SYNOPSIS: SYNthesize and OPtimize System in Silico

Novel triazine dimers with potent antitrypanosomal activity

Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants

Development and in vitro evaluation of a vaginal microbicide gel formulation for UAMC01398, a novel diaryltriazine NNRTI against HIV-1

From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds

Synthesis of Novel Diarylpyrimidine Analogues and Their Antiviral Activity against Human Immunodeficiency Virus Type 1

The conductor and his orchestra

Diaryltriazine non-nucleoside reverse transcriptase inhibitors are potent candidates for pre-exposure prophylaxis in the prevention of sexual HIV transmission

Stereotypy in schizophrenia

Synthesis, evaluation and structure–activity relationships of triazine dimers as novel antiviral agents

Evolution of anti-HIV drug candidates. Part 3: diarylpyrimidine (DAPY) analogues

Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs)

Successful pharmaceutical discovery: Paul Janssen's concept of drug research

Evolution of anti-HIV drug candidates. Part 2 : Diaryltriazine (DATA) analogues

Graphical Exploration of Gene Expression Data: A Comparative Study of Three Multivariate Methods

Design, Synthesis, and SAR of a Novel Pyrazinone Series with Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitory Activity

Preterm rabbit lung tissue mechanics: Maturational changes and effect of antenatal steroids

The effect of maternal betamethasone and fetal tracheal occlusion on pulmonary vascular morphometry in fetal rabbits with surgically induced diaphragmatic hernia: a placebo controlled morphologic study

The role of statistics in the success of a pharmaceutical research laboratory: A historical case description

Structure Based Activity Prediction of HIV-1 Reverse Transcriptase Inhibitors

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