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Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert

Neuron (Cambridge, Mass.), 2018-06, Vol.98 (6), p.1080-1098

2018

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Conformational dynamics of a class C G-protein-coupled receptor

Nature (London), 2015-08, Vol.524 (7566), p.497-501

2015

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Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function

Trends in biochemical sciences (Amsterdam. Regular ed.), 2020-12, Vol.45 (12), p.1049-1064

2020

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Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor

Journal of the American Chemical Society, 2019-07, Vol.141 (29), p.11522-11530

2019

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Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors

Neuron (Cambridge, Mass.), 2016-10, Vol.92 (1), p.143-159

2016

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Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK

Neuron (Cambridge, Mass.), 2019-01, Vol.101 (2), p.232-245.e6

2019

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Restoration of high-sensitivity and adapting vision with a cone opsin

Nature communications, 2019-03, Vol.10 (1), p.1221-1221, Article 1221

2019

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Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo

Neuron (Cambridge, Mass.), 2020-02, Vol.105 (3), p.446-463.e13

2020

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Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors

Cell reports (Cambridge), 2020-05, Vol.31 (5), p.107605-107605, Article 107605

2020

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Structural basis of agonist specificity of α1A-adrenergic receptor

Nature communications, 2023-08, Vol.14 (1), p.4819-12, Article 4819

2023

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Optical control of metabotropic glutamate receptors

Nature neuroscience, 2013-04, Vol.16 (4), p.507-516

2013

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Conformational pathway provides unique sensitivity to a synaptic mGluR

Nature communications, 2019-12, Vol.10 (1), p.5572-13, Article 5572

2019

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Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist

Journal of the American Chemical Society, 2017-12, Vol.139 (51), p.18522-18535

2017

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Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

Nature communications, 2017-11, Vol.8 (1), p.1862-12, Article 1862

2017

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Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics

Proceedings of the National Academy of Sciences - PNAS, 2015-02, Vol.112 (7), p.E776-E785

2015

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Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization

Nature communications, 2024-08, Vol.15 (1), p.6498-17, Article 6498

2024

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Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels

Proceedings of the National Academy of Sciences - PNAS, 2016-04, Vol.113 (15), p.4194-4199

2016

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Mechanism for Tunable Autoinhibition in the Structure of a Human Ca²⁺/Calmodulin- Dependent Kinase II Holoenzyme

Cell, 2011-09, Vol.146 (5), p.732-745

2011

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Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk

Cell reports (Cambridge), 2024-01, Vol.43 (1), p.113595-113595, Article 113595

2024

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Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor

eLife, 2019-06, Vol.8

2019

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Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (37), p.13547-13552

2014

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Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO)

Chemical science (Cambridge), 2016-01, Vol.7 (3), p.2347-2352

2016

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Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

Scientific reports, 2021-05, Vol.11 (1), p.10536-10536, Article 10536

2021

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Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

eLife, 2021-04, Vol.10

2021

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Advances in tethered photopharmacology for precise optical control of signaling proteins

Current opinion in pharmacology, 2022-04, Vol.63, p.102196-102196, Article 102196

2022

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Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert

Conformational dynamics of a class C G-protein-coupled receptor

Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function

Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor

Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors

Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK

Restoration of high-sensitivity and adapting vision with a cone opsin

Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo

Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors

Structural basis of agonist specificity of α1A-adrenergic receptor

Optical control of metabotropic glutamate receptors

Conformational pathway provides unique sensitivity to a synaptic mGluR

Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist

Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics

Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization

Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels

Mechanism for Tunable Autoinhibition in the Structure of a Human Ca²⁺/Calmodulin- Dependent Kinase II Holoenzyme

Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk

Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor

Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid

Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO)

Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

Advances in tethered photopharmacology for precise optical control of signaling proteins

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