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Approaches to Inducing β-Cell Regeneration

Biomedicines, 2022-02, Vol.10 (3), p.571

Levine, Fred

2022

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A potent HNF4α agonist reveals that HNF4α controls genes important in inflammatory bowel disease and Paneth cells

PloS one, 2022-04, Vol.17 (4), p.e0266066-e0266066

2022

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Liver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonist

Cell death & disease, 2021-06, Vol.12 (6), p.603-603, Article 603

2021

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Long-term oral administration of an HNF4α agonist prevents weight gain and hepatic steatosis by promoting increased mitochondrial mass and function

Cell death & disease, 2022-01, Vol.13 (1), p.89-89, Article 89

2022

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Resolving the conflicts around Par2 opposing roles in regeneration by comparing immune-mediated and toxic-induced injuries

Inflammation and regeneration, 2022-11, Vol.42

2022

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Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas

Nature medicine, 2006-03, Vol.12 (3), p.310-316

2006

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Trehalose expression confers desiccation tolerance on human cells

Nature biotechnology, 2000-02, Vol.18 (2), p.168-171

2000

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A potent HNF4[alpha] agonist reveals that HNF4[alpha] controls genes important in inflammatory bowel disease and Paneth cells

PloS one, 2022-04, Vol.17 (4), p.e0266066

2022

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Adult pancreatic alpha-cells: a new source of cells for beta-cell regeneration

The review of diabetic studies, 2010, Vol.7 (2), p.124-131

2010

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Telomere‐independent cellular senescence in human fetal cardiomyocytes

Aging cell, 2005-02, Vol.4 (1), p.21-30

2005

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Prediction of the glass transition temperature of water solutions: comparison of different models

Cryobiology, 2004-08, Vol.49 (1), p.62-82

2004

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The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma

Molecular cancer research, 2011-06, Vol.9 (6), p.782-790

2011

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Telomerase Activity Is Sufficient To Allow Transformed Cells To Escape from Crisis

Molecular and Cellular Biology, 1999-03, Vol.19 (3), p.1864-1870

1999

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β-cell replication and islet neogenesis following partial pancreatectomy

Islets, 2011-07, Vol.3 (4), p.188-195

2011

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Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic β-cells

Islets, 2011-11, Vol.3 (6), p.358-366

2011

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Phenothiazine Neuroleptics Signal to the Human Insulin Promoter as Revealed by a Novel High-Throughput Screen

Journal of biomolecular screening, 2010-07, Vol.15 (6), p.663-670

2010

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T-cadherin (Cdh13) in association with pancreatic β-cell granules contributes to second phase insulin secretion

Islets, 2011-11, Vol.3 (6), p.327-337

2011

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Islet Specific Wnt Activation in Human Type II Diabetes

Experimental diabetes research, 2008-01, Vol.2008 (1), p.728763-728763

2008

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Pancreatic β‐Cell Neogenesis by Direct Conversion from Mature α‐Cells

Stem cells (Dayton, Ohio), 2010-09, Vol.28 (9), p.1630-1638

2010

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Opposite PAR2 roles in liver regeneration from autoimmune or direct damage. Solving the conflict

Journal of hepatology, 2022-07, Vol.77, p.S742

2022

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β-cell regeneration: Neogenesis, replication or both?

Journal of molecular medicine (Berlin, Germany), 2008-03, Vol.86 (3), p.247-258

2008

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SY12-3-4 Beta-cell regeneration:Pancreatic endocrine stem cells and high-throughput screening

ENDOCRINE JOURNAL, 2010, Vol.57 (suppl.2-1), p.S291-S292

Fred Levine

2010

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High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis

Biochemical pharmacology, 2017-08, Vol.138, p.140-149

2017

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Efficient [beta]-Cell Regeneration by a Combination of Neogenesis and Replication Following [beta]-Cell Ablation and Reversal of Pancreatic Duct Ligation

Stem cells (Dayton, Ohio), 2013-11, Vol.31 (11), p.2388-2395

2013

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Insulin acts as a repressive factor to inhibit the ability of PAR2 to induce islet cell transdifferentiation

Islets, 2018-11, Vol.10 (6), p.201-212

2018

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Approaches to Inducing β-Cell Regeneration

A potent HNF4α agonist reveals that HNF4α controls genes important in inflammatory bowel disease and Paneth cells

Liver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonist

Long-term oral administration of an HNF4α agonist prevents weight gain and hepatic steatosis by promoting increased mitochondrial mass and function

Resolving the conflicts around Par2 opposing roles in regeneration by comparing immune-mediated and toxic-induced injuries

Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas

Trehalose expression confers desiccation tolerance on human cells

A potent HNF4[alpha] agonist reveals that HNF4[alpha] controls genes important in inflammatory bowel disease and Paneth cells

Adult pancreatic alpha-cells: a new source of cells for beta-cell regeneration

Telomere‐independent cellular senescence in human fetal cardiomyocytes

Prediction of the glass transition temperature of water solutions: comparison of different models

The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma

Telomerase Activity Is Sufficient To Allow Transformed Cells To Escape from Crisis

β-cell replication and islet neogenesis following partial pancreatectomy

Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic β-cells

Phenothiazine Neuroleptics Signal to the Human Insulin Promoter as Revealed by a Novel High-Throughput Screen

T-cadherin (Cdh13) in association with pancreatic β-cell granules contributes to second phase insulin secretion

Islet Specific Wnt Activation in Human Type II Diabetes

Pancreatic β‐Cell Neogenesis by Direct Conversion from Mature α‐Cells

Opposite PAR2 roles in liver regeneration from autoimmune or direct damage. Solving the conflict

β-cell regeneration: Neogenesis, replication or both?

SY12-3-4 Beta-cell regeneration:Pancreatic endocrine stem cells and high-throughput screening

High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis

Efficient [beta]-Cell Regeneration by a Combination of Neogenesis and Replication Following [beta]-Cell Ablation and Reversal of Pancreatic Duct Ligation

Insulin acts as a repressive factor to inhibit the ability of PAR2 to induce islet cell transdifferentiation

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