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A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors

Scientific reports, 2019-01, Vol.9 (1), p.201, Article 201

2019

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Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen

Journal of medicinal chemistry, 2015-02, Vol.58 (4), p.1717-1735

2015

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Structure-based optimization of non-peptidic Cathepsin D inhibitors

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (17), p.4141-4150

2014

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Anaerobic Toluene Catabolism of Thauera aromatica: the bbs Operon Codes for Enzymes of β Oxidation of the Intermediate Benzylsuccinate

Journal of Bacteriology, 2000-01, Vol.182 (2), p.272-277

2000

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Differences in Sustained Cellular Effects of MET inhibitors Are Driven by Prolonged Target Engagement and Lysosomal Retention

Molecular pharmacology, 2023-02, Vol.103 (2), p.77-88

2023

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Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects

Journal of chemical information and modeling, 2020-11, Vol.60 (11), p.5457-5474

2020

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Cryo-EM Structures of CRAF2/14-3-32 and CRAF2/14-3-32/MEK12 Complexes

Journal of molecular biology, 2024-03, Vol.436 (6), p.168483, Article 168483

2024

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Corrigendum to “Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors” [Bioorg. Med. Chem. Lett. 30 (2020) 127551]

Bioorganic & medicinal chemistry letters, 2021-10, Vol.49, p.128262-128262, Article 128262

2021

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Discovery and Optimization of 2‑Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity

Journal of medicinal chemistry, 2019-09, Vol.62 (17), p.7897-7909

2019

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Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (22), p.127551-127551, Article 127551

2020

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Abstract 1019: The MET inhibitor tepotinib shows sustained effects on MET phosphorylation and viability in cellular washout experiments

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1019-1019

2021

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Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies

Bioorganic & medicinal chemistry letters, 2019-12, Vol.29 (23), p.126717-126717, Article 126717

2019

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Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase‑2 (MetAP-2) Inhibitors

Journal of medicinal chemistry, 2019-05, Vol.62 (10), p.5025-5039

2019

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Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes

Journal of molecular biology, 2024-03, Vol.436 (6), p.168483

2024

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Identification of Methionine Aminopeptidase‑2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer

Journal of medicinal chemistry, 2019-12, Vol.62 (24), p.11119-11134

2019

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Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design

ChemMedChem, 2023-04, Vol.18 (8), p.e202200615-n/a

2023

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Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models

Molecular cancer therapeutics, 2024-02, Vol.23 (2), p.159

2024

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Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors

Journal of medicinal chemistry, 2023-07, Vol.66 (13), p.8666-8686

2023

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Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models

Journal of medicinal chemistry, 2021-07, Vol.64 (14), p.10371-10392

2021

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Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (3), p.551-556

2017

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A two-component system involved in regulation of anaerobic toluene metabolism in Thauera aromatica

FEMS microbiology letters, 1998-09, Vol.166 (1), p.35-41

1998

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Biochemical and genetic characterization of benzylsuccinate synthase from Thauera aromatica: a new glycyl radical enzyme catalysing the first step in anaerobic toluene metabolism

Molecular microbiology, 1998-05, Vol.28 (3), p.615-628

1998

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Operon structure and expression of the genes for benzylsuccinate synthase in Thauera aromatica strain K172

Archives of microbiology, 2002-02, Vol.177 (2), p.132-138

2002

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A two-component system involved in regulation of anaerobic toluene metabolism in Thauera aromatica

FEMS microbiology letters, 1998-09, Vol.166 (1), p.35-41

1998

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Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica

Archives of microbiology, 1998-08, Vol.170 (2), p.120-131

1998

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A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors

Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen

Structure-based optimization of non-peptidic Cathepsin D inhibitors

Anaerobic Toluene Catabolism of Thauera aromatica: the bbs Operon Codes for Enzymes of β Oxidation of the Intermediate Benzylsuccinate

Differences in Sustained Cellular Effects of MET inhibitors Are Driven by Prolonged Target Engagement and Lysosomal Retention

Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects

Cryo-EM Structures of CRAF2/14-3-32 and CRAF2/14-3-32/MEK12 Complexes

Corrigendum to “Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors” [Bioorg. Med. Chem. Lett. 30 (2020) 127551]

Discovery and Optimization of 2‑Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity

Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors

Abstract 1019: The MET inhibitor tepotinib shows sustained effects on MET phosphorylation and viability in cellular washout experiments

Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies

Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase‑2 (MetAP-2) Inhibitors

Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes

Identification of Methionine Aminopeptidase‑2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer

Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design

Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models

Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors

Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models

Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates

A two-component system involved in regulation of anaerobic toluene metabolism in Thauera aromatica

Biochemical and genetic characterization of benzylsuccinate synthase from Thauera aromatica: a new glycyl radical enzyme catalysing the first step in anaerobic toluene metabolism

Operon structure and expression of the genes for benzylsuccinate synthase in Thauera aromatica strain K172

A two-component system involved in regulation of anaerobic toluene metabolism in Thauera aromatica

Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica

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