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In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context

Molecular pharmaceutics, 2017-04, Vol.14 (4), p.1307-1314

2017

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Oral biopharmaceutics tools – Time for a new initiative – An introduction to the IMI project OrBiTo

European journal of pharmaceutical sciences, 2014-06, Vol.57 (SI), p.292-299

2014

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Intestinal permeability and its relevance for absorption and elimination

Xenobiotica, 2007-11, Vol.37 (10-11), p.1015-1051

Lennernaes, H

2007

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Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

European journal of pharmaceutics and biopharmaceutics, 2019-09, Vol.142, p.411-420

2019

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Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport

International journal of pharmaceutics, 2018-10, Vol.549 (1-2), p.239-248

2018

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Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability

European journal of pharmaceutics and biopharmaceutics, 2021-06, Vol.163, p.240-251

2021

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Improved Cortisol Exposure-Time Profile and Outcome in Patients with Adrenal Insufficiency: A Prospective Randomized Trial of a Novel Hydrocortisone Dual-Release Formulation

The journal of clinical endocrinology and metabolism, 2012-02, Vol.97 (2), p.473-481

2012

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Increased Understanding of Intestinal Drug Permeability Determined by the LOC-I-GUT Approach Using Multislice Computed Tomography

Molecular pharmaceutics, 2009-01, Vol.6 (1), p.2-10

2009

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Mechanistic modelling of intestinal drug absorption – The in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

European journal of pharmaceutics and biopharmaceutics, 2018-12, Vol.133, p.70-76

2018

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Rat intestinal drug permeability: A status report and summary of repeated determinations

European journal of pharmaceutics and biopharmaceutics, 2019-09, Vol.142, p.364-376

2019

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Single bead investigation of a clinical drug delivery system – A novel release mechanism

Journal of controlled release, 2018-12, Vol.292, p.235-247

2018

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Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

European journal of pharmaceutics and biopharmaceutics, 2019-09, Vol.142, p.31-37

2019

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Six years of progress in the oral biopharmaceutics area – A summary from the IMI OrBiTo project

European journal of pharmaceutics and biopharmaceutics, 2020-07, Vol.152, p.236-247

2020

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Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: a new approach to treatment of incident pain

British journal of clinical pharmacology, 2005-02, Vol.59 (2), p.249-253

2005

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Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer

European journal of pharmaceutics and biopharmaceutics, 2018-11, Vol.132, p.222-230

2018

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Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

European journal of pharmaceutics and biopharmaceutics, 2019-09, Vol.142, p.387-395

2019

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Levodopa infusion combined with entacapone or tolcapone in Parkinson disease: a pilot trial

European journal of neurology, 2012-06, Vol.19 (6), p.820-826

2012

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The progression of doxorubicin-induced intestinal mucositis in rats

Naunyn-Schmiedeberg's archives of pharmacology, 2023-02, Vol.396 (2), p.247-260

2023

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Correlation of Human Jejunal Permeability (in Vivo) of Drugs with Experimentally and Theoretically Derived Parameters. A Multivariate Data Analysis Approach

Journal of medicinal chemistry, 1998-12, Vol.41 (25), p.4939-4949

1998

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Comparison between active and passive drug transport in human intestinal epithelial (caco-2) cells in vitro and human jejunum in vivo

International journal of pharmaceutics, 1996-01, Vol.127 (1), p.103-107

1996

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Time-dependent effects on small intestinal transport by absorption-modifying excipients

European journal of pharmaceutics and biopharmaceutics, 2018-11, Vol.132, p.19-28

2018

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A miniaturized in vitro release method for investigating drug-release mechanisms

International journal of pharmaceutics, 2015, Vol.486 (1-2), p.339-349

2015

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Variable expression of CYP and Pgp genes in the human small intestine

European journal of clinical investigation, 2003-06, Vol.33 (6), p.493-499

2003

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Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

International journal of pharmaceutics, 2017-04, Vol.521 (1-2), p.274-281

2017

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Jejunal permeability : A comparison between the ussing chamber technique and the single-pass perfusion in humans

Pharmaceutical research, 1997-05, Vol.14 (5), p.667-671

1997

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In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context

Oral biopharmaceutics tools – Time for a new initiative – An introduction to the IMI project OrBiTo

Intestinal permeability and its relevance for absorption and elimination

Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport

Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability

Improved Cortisol Exposure-Time Profile and Outcome in Patients with Adrenal Insufficiency: A Prospective Randomized Trial of a Novel Hydrocortisone Dual-Release Formulation

Increased Understanding of Intestinal Drug Permeability Determined by the LOC-I-GUT Approach Using Multislice Computed Tomography

Mechanistic modelling of intestinal drug absorption – The in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

Rat intestinal drug permeability: A status report and summary of repeated determinations

Single bead investigation of a clinical drug delivery system – A novel release mechanism

Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

Six years of progress in the oral biopharmaceutics area – A summary from the IMI OrBiTo project

Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: a new approach to treatment of incident pain

Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Levodopa infusion combined with entacapone or tolcapone in Parkinson disease: a pilot trial

The progression of doxorubicin-induced intestinal mucositis in rats

Correlation of Human Jejunal Permeability (in Vivo) of Drugs with Experimentally and Theoretically Derived Parameters. A Multivariate Data Analysis Approach

Comparison between active and passive drug transport in human intestinal epithelial (caco-2) cells in vitro and human jejunum in vivo

Time-dependent effects on small intestinal transport by absorption-modifying excipients

A miniaturized in vitro release method for investigating drug-release mechanisms

Variable expression of CYP and Pgp genes in the human small intestine

Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

Jejunal permeability : A comparison between the ussing chamber technique and the single-pass perfusion in humans

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