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The Generation, Detection, and Effects of Reactive Drug Metabolites

Medicinal research reviews, 2013-09, Vol.33 (5), p.985-1080

2013

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CYP2D6 is Primarily Responsible for the Metabolism of Clomiphene

DRUG METABOLISM AND PHARMACOKINETICS, 2008-01, Vol.23 (2), p.101-105

2008

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PRN prescribing in psychiatric inpatients – potential for pharmacokinetic drug interactions

Journal of psychopharmacology (Oxford), 2007-03, Vol.21 (2), p.153-160

2007

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Evaluation of the relationship between plasma concentrations of en- and zuclomiphene and induction of ovulation in anovulatory women being treated with clomiphene citrate

Fertility and sterility, 2009-04, Vol.91 (4), p.1135-1140

2009

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Evaluation of an existing nomogram for predicting the response to clomiphene citrate

Fertility and sterility, 2007-03, Vol.87 (3), p.597-602

2007

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Influence of dose, cigarette smoking, age, sex, and metabolic activity on plasma clozapine concentrations: a predictive model and nomograms to aid clozapine dose adjustment and to assess compliance in individual patients

Journal of clinical psychopharmacology, 2004-02, Vol.24 (1), p.70-78

2004

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Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen

Drug metabolism and disposition, 2002-08, Vol.30 (8), p.869-874

2002

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Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment

British journal of clinical pharmacology, 2009-01, Vol.67 (1), p.29-37

2009

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The use of mechanistic DM‐PK‐PD modelling to assess the power of pharmacogenetic studies –CYP2C9 and warfarin as an example

British journal of clinical pharmacology, 2007-07, Vol.64 (1), p.14-26

2007

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Single-Dose Pharmacokinetic Study of Clomiphene Citrate Isomers in Anovular Patients With Polycystic Ovary Disease

Journal of clinical pharmacology, 2009-02, Vol.49 (2), p.147-154

2009

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Pharmacokinetic-pharmacodynamic modeling of mood and withdrawal symptoms in relation to plasma concentrations of methadone in patients undergoing methadone maintenance treatment

Journal of clinical psychopharmacology, 2012-10, Vol.32 (5), p.666-671

2012

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Incorporating In Vitro Information on Drug Metabolism Into Clinical Trial Simulations to Assess the Effect of CYP2D6 Polymorphism on Pharmacokinetics and Pharmacodynamics: Dextromethorphan as a Model Application

Journal of clinical pharmacology, 2007-02, Vol.47 (2), p.175-186

2007

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Monitoring plasma concentrations to individualize treatment with clomiphene citrate

Fertility and sterility, 2004-05, Vol.81 (5), p.1187-1193

2004

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Variable contribution of cytochromes p450 2d6, 2c9 and 3a4 to the 4-hydroxylation of tamoxifen by human liver microsomes

Biochemical pharmacology, 1997-01, Vol.53 (2), p.171-178

1997

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The impact of experimental design on assessing mechanism-based inactivation of CYP2D6 by MDMA (Ecstasy)

Journal of psychopharmacology (Oxford), 2006-11, Vol.20 (6), p.834-841

2006

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Metabolism of ethylbenzene by human liver microsomes and recombinant human cytochrome P450s (CYP)

Toxicology letters, 2004-03, Vol.147 (3), p.253-260

2004

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Inactivation of CYP2D6 by methylenedioxymethamphetamine in different recombinant expression systems

European journal of pharmaceutical sciences, 2007-09, Vol.32 (1), p.8-16

2007

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Can saliva replace plasma for the monitoring of methadone?

Therapeutic drug monitoring, 2005-10, Vol.27 (5), p.580-586

2005

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Solid-Phase Microextraction: Investigation of the Metabolism of Substances that May be Abused by Inhalation

Journal of chromatographic science, 2006-08, Vol.44 (7), p.387-393

2006

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Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6

Biochemical journal, 2001-04, Vol.355 (Pt 2), p.373-379

2001

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Evidence That Aspartic Acid 301 Is a Critical Substrate-Contact Residue in the Active Site of Cytochrome P450 2D6

The Journal of biological chemistry, 1995-12, Vol.270 (49), p.29055-29058

1995

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Oxidation phenotype--a major determinant of metoprolol metabolism and response

The New England journal of medicine, 1982-12, Vol.307 (25), p.1558-1560

1982

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Editors’ review of 2006 and the BJCP prize

British journal of clinical pharmacology, 2007-01, Vol.63 (1), p.1-4

2007

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Editors’ Report 2005

British journal of clinical pharmacology, 2006-05, Vol.61 (5), p.492-493

2006

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Today's science, tomorrow's medicines

British journal of clinical pharmacology, 2006-01, Vol.61 (1), p.1-4

2006

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The Generation, Detection, and Effects of Reactive Drug Metabolites

CYP2D6 is Primarily Responsible for the Metabolism of Clomiphene

PRN prescribing in psychiatric inpatients – potential for pharmacokinetic drug interactions

Evaluation of the relationship between plasma concentrations of en- and zuclomiphene and induction of ovulation in anovulatory women being treated with clomiphene citrate

Evaluation of an existing nomogram for predicting the response to clomiphene citrate

Influence of dose, cigarette smoking, age, sex, and metabolic activity on plasma clozapine concentrations: a predictive model and nomograms to aid clozapine dose adjustment and to assess compliance in individual patients

Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen

Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment

The use of mechanistic DM‐PK‐PD modelling to assess the power of pharmacogenetic studies –CYP2C9 and warfarin as an example

Single-Dose Pharmacokinetic Study of Clomiphene Citrate Isomers in Anovular Patients With Polycystic Ovary Disease

Pharmacokinetic-pharmacodynamic modeling of mood and withdrawal symptoms in relation to plasma concentrations of methadone in patients undergoing methadone maintenance treatment

Incorporating In Vitro Information on Drug Metabolism Into Clinical Trial Simulations to Assess the Effect of CYP2D6 Polymorphism on Pharmacokinetics and Pharmacodynamics: Dextromethorphan as a Model Application

Monitoring plasma concentrations to individualize treatment with clomiphene citrate

Variable contribution of cytochromes p450 2d6, 2c9 and 3a4 to the 4-hydroxylation of tamoxifen by human liver microsomes

The impact of experimental design on assessing mechanism-based inactivation of CYP2D6 by MDMA (Ecstasy)

Metabolism of ethylbenzene by human liver microsomes and recombinant human cytochrome P450s (CYP)

Inactivation of CYP2D6 by methylenedioxymethamphetamine in different recombinant expression systems

Can saliva replace plasma for the monitoring of methadone?

Solid-Phase Microextraction: Investigation of the Metabolism of Substances that May be Abused by Inhalation

Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6

Evidence That Aspartic Acid 301 Is a Critical Substrate-Contact Residue in the Active Site of Cytochrome P450 2D6

Oxidation phenotype--a major determinant of metoprolol metabolism and response

Editors’ review of 2006 and the BJCP prize

Editors’ Report 2005

Today's science, tomorrow's medicines

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