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Efficient Synthesis of Imidazoles from Aldehydes and 1,2-Diketones Using Microwave Irradiation

Organic letters, 2004-04, Vol.6 (9), p.1453-1456

2004

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High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells

Proceedings of the National Academy of Sciences - PNAS, 2014-02, Vol.111 (6), p.2349-2354

2014

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Discovery, Structure–Activity Relationship, and Biological Evaluation of Noninhibitory Small Molecule Chaperones of Glucocerebrosidase

Journal of medicinal chemistry, 2012-06, Vol.55 (12), p.5734-5748

2012

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Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.761-764

2005

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General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic pyrazines

Tetrahedron letters, 2004-06, Vol.45 (25), p.4873-4876

2004

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Evaluation of Substituted N,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase

Journal of medicinal chemistry, 2010-02, Vol.53 (3), p.1048-1055

2010

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Discovery of Potent and Selective Inhibitors of Human Reticulocyte 15-Lipoxygenase-1

Journal of medicinal chemistry, 2010-10, Vol.53 (20), p.7392-7404

2010

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Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)

Journal of medicinal chemistry, 2008-12, Vol.51 (24), p.8012-8018

2008

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Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (11), p.3387-3393

2010

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Cross-Pharma Collaboration on the Development and Evaluation of a New Mid-Scale Preparative Supercritical Fluid Chromatography Instrument

Organic process research & development, 2020-07, Vol.24 (7), p.1271-1280

2020

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Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (4), p.905-909

2005

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Structure activity relationships of human galactokinase inhibitors

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (3), p.721-727

2015

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Discovery of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 5 from a Series of N-(1,3-Diphenyl-1H- pyrazol-5-yl)benzamides That Potentiate Receptor Function in Vivo

Journal of medicinal chemistry, 2004-11, Vol.47 (24), p.5825-5828

2004

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Structure Mechanism Insights and the Role of Nitric Oxide Donation Guide the Development of Oxadiazole-2-Oxides as Therapeutic Agents against Schistosomiasis

Journal of medicinal chemistry, 2009-10, Vol.52 (20), p.6474-6483

2009

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A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide

Analytical and bioanalytical chemistry, 2012-01, Vol.402 (2), p.731-739

2012

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Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (5), p.1488-1491

2009

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A ‘one pot’ microwave-mediated synthesis of the basic canthine skeleton: expedient access to unnatural β-carboline alkaloids

Tetrahedron letters, 2003-06, Vol.44 (24), p.4495-4498

2003

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Identification of a potent new chemotype for the selective inhibition of PDE4

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (4), p.1297-1303

2008

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Discovery of GlyT1 inhibitors with improved pharmacokinetic properties

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (5), p.1492-1495

2009

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The pilot phase of the NIH Chemical Genomics Center

Current topics in medicinal chemistry, 2009-09, Vol.9 (13), p.1181

2009

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Facile High-Performance Liquid Chromatography Mass Spectrometry Method for Analysis of Cyclocreatine and Phosphocyclocreatine in Complex Mixtures of Amino Acids

Journal of agricultural and food chemistry, 2019-06, Vol.67 (25), p.7190-7196

2019

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Nature chemical biology, 2012-10, Vol.8 (10), p.839

2012

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Fluorous-tethered amine bases for organic and parallel synthesis: scope and limitations

Tetrahedron letters, 2002-09, Vol.43 (36), p.6319-6323

2002

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A general Staudinger protocol for solution-phase parallel synthesis

Tetrahedron letters, 2002-06, Vol.43 (25), p.4467-4470

2002

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Efficient Synthesis of Imidazoles from Aldehydes and 1,2-Diketones Using Microwave Irradiation

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells

Discovery, Structure–Activity Relationship, and Biological Evaluation of Noninhibitory Small Molecule Chaperones of Glucocerebrosidase

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic pyrazines

Evaluation of Substituted N,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase

Discovery of Potent and Selective Inhibitors of Human Reticulocyte 15-Lipoxygenase-1

Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

Cross-Pharma Collaboration on the Development and Evaluation of a New Mid-Scale Preparative Supercritical Fluid Chromatography Instrument

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

Structure activity relationships of human galactokinase inhibitors

Discovery of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 5 from a Series of N-(1,3-Diphenyl-1H- pyrazol-5-yl)benzamides That Potentiate Receptor Function in Vivo

Structure Mechanism Insights and the Role of Nitric Oxide Donation Guide the Development of Oxadiazole-2-Oxides as Therapeutic Agents against Schistosomiasis

A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide

Design, Synthesis, and In Vivo Efficacy of Glycine Transporter-1 (GlyT1) Inhibitors Derived from a Series of [4-Phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl Benzamides

Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors

A ‘one pot’ microwave-mediated synthesis of the basic canthine skeleton: expedient access to unnatural β-carboline alkaloids

Identification of a potent new chemotype for the selective inhibition of PDE4

Discovery of GlyT1 inhibitors with improved pharmacokinetic properties

The pilot phase of the NIH Chemical Genomics Center

Facile High-Performance Liquid Chromatography Mass Spectrometry Method for Analysis of Cyclocreatine and Phosphocyclocreatine in Complex Mixtures of Amino Acids

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Fluorous-tethered amine bases for organic and parallel synthesis: scope and limitations

A general Staudinger protocol for solution-phase parallel synthesis

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