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Quantitative Systems Pharmacology can reduce attrition and improve productivity in pharmaceutical research and development

Frontiers in pharmacology, 2014-11, Vol.5, p.247-247

2014

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Chemoimmunotherapy Reinduction With Epratuzumab in Children With Acute Lymphoblastic Leukemia in Marrow Relapse: A Children's Oncology Group Pilot Study

Journal of clinical oncology, 2008-08, Vol.26 (22), p.3756-3762

2008

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Exposure Matching‐Based Pediatric Dose Selection for Drugs with Renal Excretion – Lessons Learned from Pediatric Development of Direct Oral Anticoagulants

Clinical pharmacology and therapeutics, 2024-11, Vol.116 (5), p.1174-1187

2024

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Use of systems pharmacology modeling to elucidate the operating characteristics of SGLT1 and SGLT2 in renal glucose reabsorption in humans

Frontiers in pharmacology, 2014-12, Vol.5, p.274-274

2014

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Pharmacokinetics, Pharmacodynamics, and Safety of Edoxaban in Pediatric Subjects: A Phase I Single‐Dose Study

Clinical pharmacology and therapeutics, 2024-09, Vol.116 (3), p.736-746

2024

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Antibodies to Modulate Surface Receptor Systems Are Often Bivalent and Must Compete in a Two‐Dimensional Cell Contact Region

CPT: pharmacometrics and systems pharmacology, 2019-12, Vol.8 (12), p.873-877

2019

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Cardiac Myocyte-Specific Excision of the β1 Integrin Gene Results in Myocardial Fibrosis and Cardiac Failure

Circulation research, 2002-03, Vol.90 (4), p.458-464

2002

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Virtual Populations for Quantitative Systems Pharmacology Models

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2486, p.129

2022

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Model‐Based Meta‐Analysis Compares DAS28 Rheumatoid Arthritis Treatment Effects and Suggests an Expedited Trial Design for Early Clinical Development

Clinical pharmacology and therapeutics, 2021-02, Vol.109 (2), p.517-527

2021

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QSP Toolbox: Computational Implementation of Integrated Workflow Components for Deploying Multi-Scale Mechanistic Models

The AAPS journal, 2017-07, Vol.19 (4), p.1002-1016

2017

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Tamoxifen Induces Expression of Immune Response―Related Genes in Cultured Normal Human Mammary Epithelial Cells

Cancer research (Chicago, Ill.), 2009-02, Vol.69 (3), p.1150-1155

2009

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GABAA Receptor-Associated Protein Regulates GABAA Receptor Cell-Surface Number in Xenopus laevis Oocytes

Molecular pharmacology, 2005-07, Vol.68 (1), p.152-159

2005

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Editorial: The emerging discipline of quantitative systems pharmacology

Frontiers in pharmacology, 2015-06, Vol.6, p.129-129

2015

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Evaluating a Multiscale Mechanistic Model of the Immune System to Predict Human Immunogenicity for a Biotherapeutic in Phase 1

The AAPS journal, 2019-09, Vol.21 (5), p.94-94, Article 94

2019

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Quantitative Extrapolation: An Approach to Validation of Adult Drug Efficacy in Pediatric Subjects

Therapeutic innovation & regulatory science, 2013-09, Vol.47 (5), p.557-565

2013

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GABAA Receptor-Associated Protein Traffics GABAA Receptors to the Plasma Membrane in Neurons

The Journal of neuroscience, 2004-12, Vol.24 (50), p.11429-11438

2004

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Genes regulated by learning in the hippocampus

Journal of neuroscience research, 2003-03, Vol.71 (6), p.763-768

2003

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Modeling and Simulation of the Pharmacokinetics and Target Engagement of an Antagonist Monoclonal Antibody to Interferon‐γ–Induced Protein 10, BMS‐986184, in Healthy Participants to Guide Therapeutic Dosing

Clinical pharmacology in drug development, 2020-08, Vol.9 (6), p.689-698

2020

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A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins

CPT: pharmacometrics and systems pharmacology, 2019-11, Vol.8 (11), p.773-776

2019

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Finding new candidate genes for learning and memory

Journal of neuroscience research, 2002-04, Vol.68 (2), p.127-137

2002

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Virtual Systems Pharmacology (ViSP) software for simulation from mechanistic systems-level models

Frontiers in pharmacology, 2014-10, Vol.5, p.232-232

2014

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C-terminal modification is required for GABARAP-mediated GABA(A) receptor trafficking

The Journal of neuroscience, 2007-06, Vol.27 (25), p.6655-6663

2007

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The Emerging Discipline of Quantitative Systems Pharmacology

2015

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C-Terminal Modification Is Required for GABARAP-Mediated GABAA Receptor Trafficking

The Journal of neuroscience, 2007-06, Vol.27 (25), p.6655-6663

2007

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Identification and characterization of genetic variation in the folylpolyglutamate synthase gene

Cancer research (Chicago, Ill.), 2007-09, Vol.67 (18), p.8772-8782

2007

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Quantitative Systems Pharmacology can reduce attrition and improve productivity in pharmaceutical research and development

Chemoimmunotherapy Reinduction With Epratuzumab in Children With Acute Lymphoblastic Leukemia in Marrow Relapse: A Children's Oncology Group Pilot Study

Exposure Matching‐Based Pediatric Dose Selection for Drugs with Renal Excretion – Lessons Learned from Pediatric Development of Direct Oral Anticoagulants

Use of systems pharmacology modeling to elucidate the operating characteristics of SGLT1 and SGLT2 in renal glucose reabsorption in humans

Pharmacokinetics, Pharmacodynamics, and Safety of Edoxaban in Pediatric Subjects: A Phase I Single‐Dose Study

Antibodies to Modulate Surface Receptor Systems Are Often Bivalent and Must Compete in a Two‐Dimensional Cell Contact Region

Cardiac Myocyte-Specific Excision of the β1 Integrin Gene Results in Myocardial Fibrosis and Cardiac Failure

Virtual Populations for Quantitative Systems Pharmacology Models

Model‐Based Meta‐Analysis Compares DAS28 Rheumatoid Arthritis Treatment Effects and Suggests an Expedited Trial Design for Early Clinical Development

QSP Toolbox: Computational Implementation of Integrated Workflow Components for Deploying Multi-Scale Mechanistic Models

Tamoxifen Induces Expression of Immune Response―Related Genes in Cultured Normal Human Mammary Epithelial Cells

GABAA Receptor-Associated Protein Regulates GABAA Receptor Cell-Surface Number in Xenopus laevis Oocytes

Editorial: The emerging discipline of quantitative systems pharmacology

Evaluating a Multiscale Mechanistic Model of the Immune System to Predict Human Immunogenicity for a Biotherapeutic in Phase 1

Quantitative Extrapolation: An Approach to Validation of Adult Drug Efficacy in Pediatric Subjects

GABAA Receptor-Associated Protein Traffics GABAA Receptors to the Plasma Membrane in Neurons

Genes regulated by learning in the hippocampus

Modeling and Simulation of the Pharmacokinetics and Target Engagement of an Antagonist Monoclonal Antibody to Interferon‐γ–Induced Protein 10, BMS‐986184, in Healthy Participants to Guide Therapeutic Dosing

A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins

Finding new candidate genes for learning and memory

Virtual Systems Pharmacology (ViSP) software for simulation from mechanistic systems-level models

C-terminal modification is required for GABARAP-mediated GABA(A) receptor trafficking

The Emerging Discipline of Quantitative Systems Pharmacology

C-Terminal Modification Is Required for GABARAP-Mediated GABAA Receptor Trafficking

Identification and characterization of genetic variation in the folylpolyglutamate synthase gene

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