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Molecular mechanisms of epistasis within and between genes

Trends in genetics, 2011-08, Vol.27 (8), p.323-331

Lehner, Ben

2011

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Clustered Mutation Signatures Reveal that Error-Prone DNA Repair Targets Mutations to Active Genes

Cell, 2017-07, Vol.170 (3), p.534-547.e23

2017

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Differential DNA mismatch repair underlies mutation rate variation across the human genome

Nature (London), 2015-05, Vol.521 (7550), p.81-84

2015

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Transgenerational transmission of environmental information in C. elegans

Science (American Association for the Advancement of Science), 2017-04, Vol.356 (6335), p.320-323

2017

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Genes confer similar robustness to environmental, stochastic, and genetic perturbations in yeast

PloS one, 2010-02, Vol.5 (2), p.e9035-e9035

2010

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Conflict between noise and plasticity in yeast

PLoS genetics, 2010-11, Vol.6 (11), p.e1001185

2010

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The genetic landscape of a physical interaction

eLife, 2018-04, Vol.7

2018

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The Causes and Consequences of Genetic Interactions (Epistasis)

Annual review of genomics and human genetics, 2019-08, Vol.20 (1), p.433-460

2019

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Chromatin organization is a major influence on regional mutation rates in human cancer cells

Nature (London), 2012-08, Vol.488 (7412), p.504-507

2012

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Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits

Nature communications, 2018-07, Vol.9 (1), p.2601-13, Article 2601

2018

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Cancer type‐dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types

Molecular systems biology, 2015-07, Vol.11 (7), p.824-n/a

2015

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The rules and impact of nonsense-mediated mRNA decay in human cancers

Nature genetics, 2016-10, Vol.48 (10), p.1112-1118

2016

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Vitellogenins - Yolk Gene Function and Regulation in Caenorhabditis elegans

Frontiers in physiology, 2019-08, Vol.10, p.1067

2019

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The effects of genetic variation on gene expression dynamics during development

Nature (London), 2014-01, Vol.505 (7482), p.208-211

2014

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MUFFINN: cancer gene discovery via network analysis of somatic mutation data

Genome Biology, 2016-06, Vol.17 (1), p.129-129, Article 129

2016

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Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers

Cell, 2014-03, Vol.156 (6), p.1324-1335

2014

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Tissue specificity and the human protein interaction network

Molecular systems biology, 2009, Vol.5 (1), p.260-n/a

2009

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Biophysical ambiguities prevent accurate genetic prediction

Nature communications, 2020-10, Vol.11 (1), p.4923-4923, Article 4923

2020

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The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy

Nature genetics, 2019-11, Vol.51 (11), p.1645-1651

2019

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An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation

Nature communications, 2022-11, Vol.13 (1), p.7084-13, Article 7084

2022

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Harmonious genetic combinations rewire regulatory networks and flip gene essentiality

Nature communications, 2019-08, Vol.10 (1), p.3657-12, Article 3657

2019

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Reaching the limit

eLife, 2018-08, Vol.7

2018

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Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise

Nature communications, 2019-07, Vol.10 (1), p.3180-12, Article 3180

2019

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Chromatin organization in sperm may be the major functional consequence of base composition variation in the human genome

PLoS genetics, 2011-04, Vol.7 (4), p.e1002036-e1002036

2011

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Changes in gene expression predictably shift and switch genetic interactions

Nature communications, 2019-08, Vol.10 (1), p.3886-15, Article 3886

2019

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Molecular mechanisms of epistasis within and between genes

Clustered Mutation Signatures Reveal that Error-Prone DNA Repair Targets Mutations to Active Genes

Differential DNA mismatch repair underlies mutation rate variation across the human genome

Transgenerational transmission of environmental information in C. elegans

Genes confer similar robustness to environmental, stochastic, and genetic perturbations in yeast

Conflict between noise and plasticity in yeast

The genetic landscape of a physical interaction

The Causes and Consequences of Genetic Interactions (Epistasis)

Chromatin organization is a major influence on regional mutation rates in human cancer cells

Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits

Cancer type‐dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types

The rules and impact of nonsense-mediated mRNA decay in human cancers

Vitellogenins - Yolk Gene Function and Regulation in Caenorhabditis elegans

The effects of genetic variation on gene expression dynamics during development

MUFFINN: cancer gene discovery via network analysis of somatic mutation data

Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers

Tissue specificity and the human protein interaction network

Biophysical ambiguities prevent accurate genetic prediction

The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy

An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation

Harmonious genetic combinations rewire regulatory networks and flip gene essentiality

Reaching the limit

Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise

Chromatin organization in sperm may be the major functional consequence of base composition variation in the human genome

Changes in gene expression predictably shift and switch genetic interactions

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