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Galectins at a glance

Journal of cell science, 2018-05, Vol.131 (9), p.jcs208884-jcs208884

2018

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Extracellular and intracellular small-molecule galectin-3 inhibitors

Scientific reports, 2019-02, Vol.9 (1), p.2186, Article 2186

2019

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Galectin History, Some Stories, and Some Outstanding Questions

Trends in Glycoscience and Glycotechnology, 2018/05/25, Vol.30(172), pp.SE129-SE135

Leffler, Hakon

2018

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Interplay between Conformational Entropy and Solvation Entropy in Protein–Ligand Binding

Journal of the American Chemical Society, 2019-02, Vol.141 (5), p.2012-2026

2019

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Regulation of Transforming Growth Factor-β1-driven Lung Fibrosis by Galectin-3

American journal of respiratory and critical care medicine, 2012-03, Vol.185 (5), p.537-546

2012

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Ligand Induced Galectin-3 Protein Self-association

The Journal of biological chemistry, 2012-06, Vol.287 (26), p.21751-21756

2012

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Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3

Nature communications, 2016-04, Vol.7 (1), p.11302-11302, Article 11302

2016

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A Selective Galactose–Coumarin-Derived Galectin‑3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.8141-8147

2016

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Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3

Journal of the American Chemical Society, 2010-10, Vol.132 (41), p.14577-14589

2010

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Galectin-3, a marker for vacuole lysis by invasive pathogens

Cellular microbiology, 2010-04, Vol.12 (4), p.530-544

2010

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Galectin-1, -2, and -3 Exhibit Differential Recognition of Sialylated Glycans and Blood Group Antigens

The Journal of biological chemistry, 2008-04, Vol.283 (15), p.10109-10123

2008

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Entropy–Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C

JACS Au, 2021-04, Vol.1 (4), p.484-500

2021

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Different angioregulatory activity of monovalent galectin-9 isoforms

Angiogenesis (London), 2018-08, Vol.21 (3), p.545-555

2018

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Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2021-09, Vol.24 (5), p.1050-1062

2021

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Regulation of Alternative Macrophage Activation by Galectin-3

The Journal of immunology (1950), 2008-02, Vol.180 (4), p.2650-2658

2008

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The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

Biochemistry (Easton), 2012-01, Vol.51 (1), p.296-306

2012

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Structural characterization of human galectin‐4 C‐terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens

The FEBS journal, 2015-09, Vol.282 (17), p.3348-3367

2015

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Galectin‐3 type‐C self‐association on neutrophil surfaces; The carbohydrate recognition domain regulates cell function

Journal of leukocyte biology, 2018-02, Vol.103 (2), p.341-353

2018

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A Galactoside-Binding Protein Tricked into Binding Unnatural Pyranose Derivatives: 3-Deoxy-3-Methyl-Gulosides Selectively Inhibit Galectin-1

International journal of molecular sciences, 2019-08, Vol.20 (15), p.3786

2019

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Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance

International journal of molecular sciences, 2024-06, Vol.25 (12), p.6704

2024

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Differential Roles of Galectin-1 and Galectin-3 in Regulating Leukocyte Viability and Cytokine Secretion

The Journal of immunology (1950), 2008-03, Vol.180 (5), p.3091-3102

2008

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Intra- and intermolecular interactions of human galectin-3: assessment by full-assignment-based NMR

Glycobiology (Oxford), 2016-08, Vol.26 (8), p.888-903

2016

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Letter by Leffler Regarding Article, “Modified Citrus Pectin Prevents Blood-Brain Barrier Disruption in Mouse Subarachnoid Hemorrhage by Inhibiting Galectin-3”

Stroke (1970), 2019-05, Vol.50 (5), p.e136-e136

Leffler, Hakon

2019

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The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis

Frontiers in pharmacology, 2024-07, Vol.15, p.1430109

2024

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Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2021-09, Vol.24 (5), p.1050-1062

2021

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Galectins at a glance

Extracellular and intracellular small-molecule galectin-3 inhibitors

Galectin History, Some Stories, and Some Outstanding Questions

Interplay between Conformational Entropy and Solvation Entropy in Protein–Ligand Binding

Regulation of Transforming Growth Factor-β1-driven Lung Fibrosis by Galectin-3

Ligand Induced Galectin-3 Protein Self-association

Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3

A Selective Galactose–Coumarin-Derived Galectin‑3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model

Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3

Galectin-3, a marker for vacuole lysis by invasive pathogens

Galectin-1, -2, and -3 Exhibit Differential Recognition of Sialylated Glycans and Blood Group Antigens

Entropy–Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C

Different angioregulatory activity of monovalent galectin-9 isoforms

Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression

Regulation of Alternative Macrophage Activation by Galectin-3

The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

Structural characterization of human galectin‐4 C‐terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens

Galectin‐3 type‐C self‐association on neutrophil surfaces; The carbohydrate recognition domain regulates cell function

A Galactoside-Binding Protein Tricked into Binding Unnatural Pyranose Derivatives: 3-Deoxy-3-Methyl-Gulosides Selectively Inhibit Galectin-1

Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance

Differential Roles of Galectin-1 and Galectin-3 in Regulating Leukocyte Viability and Cytokine Secretion

Intra- and intermolecular interactions of human galectin-3: assessment by full-assignment-based NMR

Letter by Leffler Regarding Article, “Modified Citrus Pectin Prevents Blood-Brain Barrier Disruption in Mouse Subarachnoid Hemorrhage by Inhibiting Galectin-3”

The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis

Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression

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