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Mathematical modelling of oxygen gradients in stem cell-derived liver tissue

PloS one, 2021-02, Vol.16 (2), p.e0244070-e0244070

2021

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An advanced in silico model of the oral mucosa reveals the impact of extracellular spaces on chemical permeation

International journal of pharmaceutics, 2024-12, Vol.666, p.124827, Article 124827

2024

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A mathematical investigation into the uptake kinetics of nanoparticles in vitro

PloS one, 2021-07, Vol.16 (7), p.e0254208

2021

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Multiscale modelling of drug transport and metabolism in liver spheroids

Interface focus, 2020-04, Vol.10 (2), p.20190041-20190041

2020

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Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture

PloS one, 2018-11, Vol.13 (11), p.e0207803-e0207803

2018

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Projecting malaria hazard from climate change in eastern Africa using large ensembles to estimate uncertainty

Geospatial health, 2016-03, Vol.11 (1 Suppl), p.393-393

2016

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A dynamic, climate-driven model of Rift Valley fever

Geospatial health, 2016-03, Vol.11 (1 Suppl), p.394-394

2016

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Environmental change and Rift Valley fever in eastern Africa: projecting beyond HEALTHY FUTURES

Geospatial health, 2016-03, Vol.11 (1 Suppl), p.387-387

2016

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A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity

iScience, 2018-06, Vol.4, p.84-96

2018

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Modelling changes in glutathione homeostasis as a function of quinone redox metabolism

Scientific reports, 2019-04, Vol.9 (1), p.6333, Article 6333

2019

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Impact of cell types and culture methods on the functionality of in vitro liver systems – A review of cell systems for hepatotoxicity assessment

Toxicology in vitro, 2018-04, Vol.48, p.262-275

2018

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Characterisation of a functional rat hepatocyte spheroid model

Toxicology in vitro, 2019-03, Vol.55, p.160-172

2019

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Modelling the impact of changes in the extracellular environment on the cytosolic free NAD.sup.+/NADH ratio during cell culture

PloS one, 2018-11, Vol.13 (11), p.e0207803

2018

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Using Read-Across to build Physiologically-Based Kinetic models: Part 2. Case studies for atenolol and flumioxazin

Computational toxicology, 2024-03, Vol.29, p.100293, Article 100293

2024

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Using read-across to build physiologically-based kinetic models: Part 1. Development of a KNIME workflow to assist analogue selection for PBK modelling

Computational toxicology, 2024-03, Vol.29, p.100292, Article 100292

2024

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Tight Control of Hypoxia-inducible Factor-α Transient Dynamics Is Essential for Cell Survival in Hypoxia

The Journal of biological chemistry, 2014-02, Vol.289 (9), p.5549-5564

2014

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Modeling the dynamics of hypoxia inducible factor-1α (HIF-1α) within single cells and 3D cell culture systems

Mathematical biosciences, 2014-12, Vol.258, p.33-43

2014

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Mathematical modelling and statistical analysis of indocyanine green and other biomarkers of hepatic function and drug-induced liver injury

Computational toxicology, 2020-11, Vol.16, p.100134, Article 100134

2020

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A systems toxicology paracetamol overdose framework: accounting for high-risk individuals

Computational toxicology, 2019-11, Vol.12, p.100103, Article 100103

2019

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In silico-guided optimisation of oxygen gradients in hepatic spheroids

Computational toxicology, 2019-11, Vol.12, p.100093, Article 100093

2019

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Preparation of Primary Rat Hepatocyte Spheroids Utilizing the Liquid‐Overlay Technique

Current Protocols in Toxicology, 2019-09, Vol.81 (1), p.e87-n/a

2019

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Systems Toxicology Approach to Identifying Paracetamol Overdose

CPT: pharmacometrics and systems pharmacology, 2018-06, Vol.7 (6), p.394-403

2018

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Modelling hif-1α dynamics within single cells and neurospheres

Leedale, Joseph

2013

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Mathematical modelling of oxygen gradients in stem cell-derived liver tissue

An advanced in silico model of the oral mucosa reveals the impact of extracellular spaces on chemical permeation

A mathematical investigation into the uptake kinetics of nanoparticles in vitro

Multiscale modelling of drug transport and metabolism in liver spheroids

Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture

Projecting malaria hazard from climate change in eastern Africa using large ensembles to estimate uncertainty

A dynamic, climate-driven model of Rift Valley fever

Environmental change and Rift Valley fever in eastern Africa: projecting beyond HEALTHY FUTURES

A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity

Modelling changes in glutathione homeostasis as a function of quinone redox metabolism

Impact of cell types and culture methods on the functionality of in vitro liver systems – A review of cell systems for hepatotoxicity assessment

Characterisation of a functional rat hepatocyte spheroid model

Modelling the impact of changes in the extracellular environment on the cytosolic free NAD.sup.+/NADH ratio during cell culture

Using Read-Across to build Physiologically-Based Kinetic models: Part 2. Case studies for atenolol and flumioxazin

Using read-across to build physiologically-based kinetic models: Part 1. Development of a KNIME workflow to assist analogue selection for PBK modelling

Tight Control of Hypoxia-inducible Factor-α Transient Dynamics Is Essential for Cell Survival in Hypoxia

Modeling the dynamics of hypoxia inducible factor-1α (HIF-1α) within single cells and 3D cell culture systems

Mathematical modelling and statistical analysis of indocyanine green and other biomarkers of hepatic function and drug-induced liver injury

A systems toxicology paracetamol overdose framework: accounting for high-risk individuals

Challenges and opportunities for overcoming dog use in agrochemical evaluation and registration

In silico-guided optimisation of oxygen gradients in hepatic spheroids

Preparation of Primary Rat Hepatocyte Spheroids Utilizing the Liquid‐Overlay Technique

Systems Toxicology Approach to Identifying Paracetamol Overdose

Modelling hif-1α dynamics within single cells and neurospheres

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