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Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (13), p.1-10

2021

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Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

Proceedings of the National Academy of Sciences - PNAS, 2014-11, Vol.111 (47), p.E5114-E5122

2014

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Piezo1 Regulation In Cartilage And Joint-Innervating Nerve Using An ACL-Injury-Induced Mouse OA Model

The journal of pain, 2023-04, Vol.24 (4), p.44-44

Lee, Whasil

2023

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TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor

Pain (Amsterdam), 2014-12, Vol.155 (12), p.2662-2672

2014

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The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis

Frontiers in cell and developmental biology, 2022-05, Vol.10, p.885224

2022

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Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain

Scientific reports, 2016-06, Vol.6 (1), p.26894-26894, Article 26894

2016

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PIEZO1 is downregulated in glenohumeral chondrocytes in early cuff tear arthropathy following a massive rotator cuff tear in a mouse model

Frontiers in bioengineering and biotechnology, 2023-09, Vol.11, p.1244975-1244975

2023

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Effect of knee joint loading on chondrocyte mechano-vulnerability and severity of post-traumatic osteoarthritis induced by ACL-injury in mice

Osteoarthritis and cartilage open, 2022-03, Vol.4 (1), p.100227-100227, Article 100227

2022

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Mechanical Unfolding of an Ankyrin Repeat Protein

Biophysical journal, 2010-04, Vol.98 (7), p.1294-1301

2010

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Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement

Journal of visualized experiments, 2023-12 (202)

2023

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Inflammatory Cytokine Il-1α Up-Regulates Piezo1 and Hyper-Sensitizes Chondrocytes to Compression

Biophysical journal, 2016-02, Vol.110 (3), p.349a-349a

2016

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UVA Generates Pyrimidine Dimers in DNA Directly

Biophysical journal, 2009-02, Vol.96 (3), p.1151-1158

2009

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Hydrogel Swelling-Mediated Strain Induces Cell Alignment at Dentin Interfaces

ACS biomaterials science & engineering, 2022-08, Vol.8 (8), p.3568-3575

2022

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Characterization of Mechanotransensitivity of Articular Chondrocytes

Biophysical journal, 2014-01, Vol.106 (2), p.389a-390a

2014

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Full Reconstruction of a Vectorial Protein Folding Pathway by Atomic Force Microscopy and Molecular Dynamics Simulations

The Journal of biological chemistry, 2010-12, Vol.285 (49), p.38167-38172

2010

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Fast and Forceful Refolding of Stretched α-Helical Solenoid Proteins

Biophysical journal, 2010-06, Vol.98 (12), p.3086-3092

2010

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Fast and Forceful Refolding of Stretched [alpha]-Helical Solenoid Proteins

Biophysical journal, 2010-06, Vol.98 (12), p.3086

2010

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Mutation of Conserved Histidines Alters Tertiary Structure and Nanomechanics of Consensus Ankyrin Repeats

The Journal of biological chemistry, 2012-06, Vol.287 (23), p.19115-19121

2012

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Mutation of conserved histidines alters tertiary structure and nanomechanics of consensus ankyrin repeats

The Journal of biological chemistry, 2012-10, Vol.287 (42), p.35539-35539

2012

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Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

Proceedings of the National Academy of Sciences - PNAS, 2014-11, Vol.111 (47), p.16646-16646

2014

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Mechanical Anisotropy of Ankyrin Repeats

Biophysical journal, 2012-03, Vol.102 (5), p.1118-1126

2012

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Nanomechanics of Ankyrin-R Repeats Probed by AFM and SMD Simulations

Biophysical journal, 2010-01, Vol.98 (3), p.447a-447a

2010

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Full Reconstruction of a Vectorial Protein Folding Pathway by Afm and Smd: Insights Into the Co-Translational Folding of the Nascent-Polypeptide-Chain

Biophysical journal, 2011-02, Vol.100 (3), p.483a-483a

2011

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Full reconstruction of a vectorial protein folding pathway by atomic force microscopy and molecular dynamics simulations

The Journal of biological chemistry, 2011-03, Vol.286 (10), p.8708-8708

2011

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Single-Molecule Atomic-Force Spectroscopy Captures a Novel Class of Molecular Nanosprings with Robust Stepwise Refolding Properties

Biophysical journal, 2010-01, Vol.98 (3), p.593a-594a

2010

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Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

Piezo1 Regulation In Cartilage And Joint-Innervating Nerve Using An ACL-Injury-Induced Mouse OA Model

TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor

The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis

Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain

PIEZO1 is downregulated in glenohumeral chondrocytes in early cuff tear arthropathy following a massive rotator cuff tear in a mouse model

Effect of knee joint loading on chondrocyte mechano-vulnerability and severity of post-traumatic osteoarthritis induced by ACL-injury in mice

Mechanical Unfolding of an Ankyrin Repeat Protein

Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement

Inflammatory Cytokine Il-1α Up-Regulates Piezo1 and Hyper-Sensitizes Chondrocytes to Compression

UVA Generates Pyrimidine Dimers in DNA Directly

Hydrogel Swelling-Mediated Strain Induces Cell Alignment at Dentin Interfaces

Characterization of Mechanotransensitivity of Articular Chondrocytes

Full Reconstruction of a Vectorial Protein Folding Pathway by Atomic Force Microscopy and Molecular Dynamics Simulations

Fast and Forceful Refolding of Stretched α-Helical Solenoid Proteins

Fast and Forceful Refolding of Stretched [alpha]-Helical Solenoid Proteins

Mutation of Conserved Histidines Alters Tertiary Structure and Nanomechanics of Consensus Ankyrin Repeats

Mutation of conserved histidines alters tertiary structure and nanomechanics of consensus ankyrin repeats

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

Mechanical Anisotropy of Ankyrin Repeats

Nanomechanics of Ankyrin-R Repeats Probed by AFM and SMD Simulations

Full Reconstruction of a Vectorial Protein Folding Pathway by Afm and Smd: Insights Into the Co-Translational Folding of the Nascent-Polypeptide-Chain

Full reconstruction of a vectorial protein folding pathway by atomic force microscopy and molecular dynamics simulations

Single-Molecule Atomic-Force Spectroscopy Captures a Novel Class of Molecular Nanosprings with Robust Stepwise Refolding Properties

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