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Heat Shock Protein 90: Inhibitors in Clinical Trials

Journal of medicinal chemistry, 2010-01, Vol.53 (1), p.3-17

2010

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Small Molecular Inhibitor of Transforming Growth Factor-β Protects Against Development of Radiation-Induced Lung Injury

International journal of radiation oncology, biology, physics, 2008-07, Vol.71 (3), p.829-837

2008

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A modified Curtius reaction: an efficient and simple method for direct isolation of free amine

Tetrahedron letters, 2010-01, Vol.51 (2), p.385-386

2010

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Tgf-beta type I receptor (Alk5) kinase inhibitors in oncology

Current pharmaceutical biotechnology, 2011-12, Vol.12 (12), p.2190-2202

2011

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The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis

Cancer Immunology, Immunotherapy, 2012-04, Vol.61 (4), p.511-521

2012

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Strategies for TGF-β modulation: a review of recent patents

Expert opinion on therapeutic patents, 2009-12, Vol.19 (12), p.1759-1769

2009

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Stereochemistry–activity relationship of orally active tetralin S1P agonist prodrugs

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2264-2269

2010

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Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.3078-3083

2011

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A novel small-molecule inhibitor of transforming growth factor β type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection

Cancer research (Chicago, Ill.), 2007-03, Vol.67 (5), p.2351-2359

2007

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Intracellular TGF-β Receptor Blockade Abrogates Smad-Dependent Fibroblast Activation In Vitro and In Vivo

Journal of investigative dermatology, 2006-08, Vol.126 (8), p.1733-1744

2006

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A Kinase-focused Compound Collection: Compilation and Screening Strategy

Chemical biology & drug design, 2006-06, Vol.67 (6), p.385-394

2006

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An Abiotic Strategy for the Enantioselective Synthesis of Erythromycin B

Angewandte Chemie International Edition, 2003-07, Vol.42 (28), p.3278-3281

2003

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Duplexed, bead‐based competitive assay for inhibitors of protein kinases

Cytometry. Part A, 2007-07, Vol.71A (7), p.451-459

2007

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SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model

Arteriosclerosis, thrombosis, and vascular biology, 2008-04, Vol.28 (4), p.665-671

2008

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Pyrazolone based TGFβR1 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.326-329

2010

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Rational design of potent and selective VLA-4 inhibitors and their utility in the treatment of asthma

Current topics in medicinal chemistry, 2004-01, Vol.4 (14), p.1497-1507

2004

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Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (24), p.4355-4359

2003

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Total synthesis of erythromycin B

Tetrahedron, 2007-06, Vol.63 (26), p.5709-5729

2007

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An Orally Active Small Molecule TGF-β Receptor I Antagonist Inhibits the Growth of Metastatic Murine Breast Cancer

Anticancer research, 2009-06, Vol.29 (6), p.2099-2109

2009

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2-Aminoimidazoles inhibitors of TGF-β receptor 1

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.912-916

2009

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Selective, Tight-Binding Inhibitors of Integrin α4β1 That Inhibit Allergic Airway Responses

Journal of medicinal chemistry, 1999-03, Vol.42 (5), p.920-934

1999

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Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I)

Bioorganic & medicinal chemistry letters, 2011-09, Vol.21 (18), p.5633-5637

2011

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Identification of Potent and Novel α4β1 Antagonists Using in Silico Screening

Journal of medicinal chemistry, 2002-07, Vol.45 (14), p.2988-2993

2002

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Strategies for Macrolide Synthesis. A Concise Approach to Protected Seco-Acids of Erythronolides A and B

Journal of the American Chemical Society, 1994-06, Vol.116 (11), p.4674-4688

1994

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Effect of metal counterions on the stereoselectivity of aldol reactions used to assemble the seco acid backbone of erythromycin b

Tetrahedron letters, 1993-04, Vol.34 (17), p.2711-2714

1993

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Heat Shock Protein 90: Inhibitors in Clinical Trials

Small Molecular Inhibitor of Transforming Growth Factor-β Protects Against Development of Radiation-Induced Lung Injury

A modified Curtius reaction: an efficient and simple method for direct isolation of free amine

Tgf-beta type I receptor (Alk5) kinase inhibitors in oncology

The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis

Strategies for TGF-β modulation: a review of recent patents

Stereochemistry–activity relationship of orally active tetralin S1P agonist prodrugs

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery

A novel small-molecule inhibitor of transforming growth factor β type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection

Intracellular TGF-β Receptor Blockade Abrogates Smad-Dependent Fibroblast Activation In Vitro and In Vivo

A Kinase-focused Compound Collection: Compilation and Screening Strategy

An Abiotic Strategy for the Enantioselective Synthesis of Erythromycin B

Duplexed, bead‐based competitive assay for inhibitors of protein kinases

SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model

Pyrazolone based TGFβR1 kinase inhibitors

Rational design of potent and selective VLA-4 inhibitors and their utility in the treatment of asthma

Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)

Total synthesis of erythromycin B

An Orally Active Small Molecule TGF-β Receptor I Antagonist Inhibits the Growth of Metastatic Murine Breast Cancer

2-Aminoimidazoles inhibitors of TGF-β receptor 1

Selective, Tight-Binding Inhibitors of Integrin α4β1 That Inhibit Allergic Airway Responses

Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I)

Identification of Potent and Novel α4β1 Antagonists Using in Silico Screening

Strategies for Macrolide Synthesis. A Concise Approach to Protected Seco-Acids of Erythronolides A and B

Effect of metal counterions on the stereoselectivity of aldol reactions used to assemble the seco acid backbone of erythromycin b

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