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AKT as a Therapeutic Target for Cancer

Cancer research (Chicago, Ill.), 2019-03, Vol.79 (6), p.1019-1031

2019

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Vitamin C alleviates hyperuricemia nephropathy by reducing inflammation and fibrosis

Journal of food science, 2021-07, Vol.86 (7), p.3265-3276

2021

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Targeting LIMK1 with luteolin inhibits the growth of lung cancer in vitro and in vivo

Journal of cellular and molecular medicine, 2021-06, Vol.25 (12), p.5560-5571

2021

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Acetylshikonin suppressed growth of colorectal tumour tissue and cells by inhibiting the intracellular kinase, T‐lymphokine‐activated killer cell‐originated protein kinase

British journal of pharmacology, 2020-05, Vol.177 (10), p.2303-2319

2020

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Implications of Genetic and Epigenetic Alterations of CDKN2A (p16INK4a) in Cancer

EBioMedicine, 2016-06, Vol.8 (C), p.30-39

2016

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Echinatin induces reactive oxygen species‐mediated apoptosis via JNK/p38 MAPK signaling pathway in colorectal cancer cells

Phytotherapy research, 2023-02, Vol.37 (2), p.563-577

2023

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Costunolide is a dual inhibitor of MEK1 and AKT1/2 that overcomes osimertinib resistance in lung cancer

Molecular cancer, 2022-10, Vol.21 (1), p.1-193, Article 193

2022

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Targeted therapy of the AKT kinase inhibits esophageal squamous cell carcinoma growth in vitro and in vivo

International journal of cancer, 2019-08, Vol.145 (4), p.1007-1019

2019

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Targeting ROCK/LIMK/cofilin signaling pathway in cancer

Archives of Pharmacal Research, 2019, 42(6), , pp.481-491

2019

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Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration

International journal of molecular sciences, 2021-06, Vol.22 (13), p.6794

2021

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Targeting AKT with Oridonin Inhibits Growth of Esophageal Squamous Cell Carcinoma In Vitro and Patient-Derived Xenografts In Vivo

Molecular cancer therapeutics, 2018-07, Vol.17 (7), p.1540-1553

2018

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The 3-deoxysappanchalcone induces ROS-mediated apoptosis and cell cycle arrest via JNK/p38 MAPKs signaling pathway in human esophageal cancer cells

Phytomedicine (Stuttgart), 2021-06, Vol.86, p.153564-153564, Article 153564

2021

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PBK/TOPK: An Effective Drug Target with Diverse Therapeutic Potential

Cancers, 2021-05, Vol.13 (9), p.2232

2021

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Targeting TAOK1 with resveratrol inhibits esophageal squamous cell carcinoma growth in vitro and in vivo

Molecular carcinogenesis, 2024-05, Vol.63 (5), p.991-1008

2024

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Induction of Autophagy by Extract from Corydalis heterocarpa for Skin Anti-Aging

Marine drugs, 2024-03, Vol.22 (3), p.127

2024

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Janus kinase 2 inhibition by Licochalcone B suppresses esophageal squamous cell carcinoma growth

Phytotherapy research, 2020-08, Vol.34 (8), p.2032-2043

2020

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FGFR2 regulation by picrasidine Q inhibits the cell growth and induces apoptosis in esophageal squamous cell carcinoma

Journal of cellular biochemistry, 2018-02, Vol.119 (2), p.2231-2239

2018

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USP8 Is a Novel Target for Overcoming Gefitinib Resistance in Lung Cancer

Clinical cancer research, 2013-07, Vol.19 (14), p.3894-3904

2013

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Picropodophyllotoxin, an Epimer of Podophyllotoxin, Causes Apoptosis of Human Esophageal Squamous Cell Carcinoma Cells Through ROS-Mediated JNK/P38 MAPK Pathways

International journal of molecular sciences, 2020-06, Vol.21 (13), p.4640

2020

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Licochalcone C induced apoptosis in human oral squamous cell carcinoma cells by regulation of the JAK2/STAT3 signaling pathway

Journal of cellular biochemistry, 2018-12, Vol.119 (12), p.10118-10130

2018

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Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis

Cell death & disease, 2018-03, Vol.9 (3), p.401-21, Article 401

2018

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Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo

Journal of experimental & clinical cancer research, 2021-03, Vol.40 (1), p.114-114, Article 114

2021

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Licochalcone D directly targets JAK2 to induced apoptosis in human oral squamous cell carcinoma

Journal of cellular physiology, 2019-02, Vol.234 (2), p.1780-1793

2019

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Licochalcone B inhibits growth and induces apoptosis of human non-small-cell lung cancer cells by dual targeting of EGFR and MET

Phytomedicine (Stuttgart), 2019-10, Vol.63, p.153014-153014, Article 153014

2019

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A Small Molecule Antagonist of PD-1/PD-L1 Interactions Acts as an Immune Checkpoint Inhibitor for NSCLC and Melanoma Immunotherapy

Frontiers in immunology, 2021-05, Vol.12, p.654463-654463

2021

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AKT as a Therapeutic Target for Cancer

Vitamin C alleviates hyperuricemia nephropathy by reducing inflammation and fibrosis

Targeting LIMK1 with luteolin inhibits the growth of lung cancer in vitro and in vivo

Acetylshikonin suppressed growth of colorectal tumour tissue and cells by inhibiting the intracellular kinase, T‐lymphokine‐activated killer cell‐originated protein kinase

Implications of Genetic and Epigenetic Alterations of CDKN2A (p16INK4a) in Cancer

Echinatin induces reactive oxygen species‐mediated apoptosis via JNK/p38 MAPK signaling pathway in colorectal cancer cells

Costunolide is a dual inhibitor of MEK1 and AKT1/2 that overcomes osimertinib resistance in lung cancer

Targeted therapy of the AKT kinase inhibits esophageal squamous cell carcinoma growth in vitro and in vivo

Targeting ROCK/LIMK/cofilin signaling pathway in cancer

Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration

Targeting AKT with Oridonin Inhibits Growth of Esophageal Squamous Cell Carcinoma In Vitro and Patient-Derived Xenografts In Vivo

The 3-deoxysappanchalcone induces ROS-mediated apoptosis and cell cycle arrest via JNK/p38 MAPKs signaling pathway in human esophageal cancer cells

PBK/TOPK: An Effective Drug Target with Diverse Therapeutic Potential

Targeting TAOK1 with resveratrol inhibits esophageal squamous cell carcinoma growth in vitro and in vivo

Induction of Autophagy by Extract from Corydalis heterocarpa for Skin Anti-Aging

Janus kinase 2 inhibition by Licochalcone B suppresses esophageal squamous cell carcinoma growth

FGFR2 regulation by picrasidine Q inhibits the cell growth and induces apoptosis in esophageal squamous cell carcinoma

USP8 Is a Novel Target for Overcoming Gefitinib Resistance in Lung Cancer

Picropodophyllotoxin, an Epimer of Podophyllotoxin, Causes Apoptosis of Human Esophageal Squamous Cell Carcinoma Cells Through ROS-Mediated JNK/P38 MAPK Pathways

Licochalcone C induced apoptosis in human oral squamous cell carcinoma cells by regulation of the JAK2/STAT3 signaling pathway

Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis

Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo

Licochalcone D directly targets JAK2 to induced apoptosis in human oral squamous cell carcinoma

Licochalcone B inhibits growth and induces apoptosis of human non-small-cell lung cancer cells by dual targeting of EGFR and MET

A Small Molecule Antagonist of PD-1/PD-L1 Interactions Acts as an Immune Checkpoint Inhibitor for NSCLC and Melanoma Immunotherapy

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