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Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC)

Biochemical and biophysical research communications, 2018-10, Vol.505 (2), p.542-547

2018

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Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer

PloS one, 2018-06, Vol.13 (6), p.e0198347-e0198347

2018

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Design and characterization of cereblon-mediated androgen receptor proteolysis-targeting chimeras

European journal of medicinal chemistry, 2020-12, Vol.208, p.112769-112769, Article 112769

2020

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A novel cereblon modulator for targeted protein degradation

European journal of medicinal chemistry, 2019-03, Vol.166, p.65-74

2019

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Synthesis and cytotoxicity of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives

Bioorganic & medicinal chemistry, 2004-07, Vol.12 (13), p.3683-3686

2004

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Structure–Activity Relationship of Oleanane Disaccharides Isolated from Akebia quinata versus Cytotoxicity against Cancer Cells and NO Inhibition

Biological and Pharmaceutical Bulletin, 2004, Vol.27(5), pp.744-747

2004

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Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM)

European journal of medicinal chemistry, 2015-10, Vol.103, p.210-222

2015

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Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5- g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition

Bioorganic & medicinal chemistry, 2008-04, Vol.16 (8), p.4545-4550

2008

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In vivo distribution and antitumor activity of heparin-stabilized doxorubicin-loaded liposomes

International journal of pharmaceutics, 2006-04, Vol.313 (1), p.181-188

2006

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Cytotoxic steroidal saponins from the rhizomes of Asparagus oligoclonos

Journal of natural products (Washington, D.C.), 2005-05, Vol.68 (5), p.766-768

2005

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Synthesis and structure–activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors

Bioorganic & medicinal chemistry letters, 2012-06, Vol.22 (12), p.4044-4048

2012

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Discovery of aminopyridines substituted with benzoxazole as orally active c-Met kinase inhibitors

Bioorganic & medicinal chemistry letters, 2010-07, Vol.20 (14), p.4223-4227

2010

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Cytotoxic Compounds from a Two-Sponge Association

Journal of natural products (Washington, D.C.), 1995-11, Vol.58 (11), p.1722-1726

1995

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3D-QSAR studies of cytotoxic heterocyclic quinones using calculated reduction potential

Drug development research, 2009-09, Vol.70 (6), p.438-444

2009

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Synthesis, cytotoxicity, and DNA topoisomerase II inhibitory activity of benzofuroquinolinediones

Bioorganic & medicinal chemistry, 2007-02, Vol.15 (4), p.1651-1658

2007

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Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (23), p.7185-7188

2011

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Synthesis, topoisomerase I inhibition and structure-activity relationship study of 2,4,6-trisubstituted pyridine derivatives

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1333-1337

2004

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BCNU-loaded poly( d, l-lactide-co-glycolide) wafer and antitumor activity against XF-498 human CNS tumor cells in vitro

International journal of pharmaceutics, 2003-01, Vol.251 (1), p.1-12

2003

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New Bioactive Cerebrosides from Arisaema amurense

Journal of natural products (Washington, D.C.), 1996-03, Vol.59 (3), p.319-322

1996

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Synthesis and cytotoxicity evaluation of 2-amino- and 2-hidroxy-3-ethoxycarbonyl-N-substituted-benzo[f]indole-4,9-dione derivatives

Bioorganic & medicinal chemistry, 2003-04, Vol.11 (7), p.1511-1519

2003

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Differential effects of the optical isomers of KR30031 on cardiotoxicity and on multidrug resistance reversal activity

Anti-cancer drugs, 2003-02, Vol.14 (2), p.175-181

2003

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Synthesis and cytotoxicity of 6,11-Dihydro-pyrido- and 6,11-Dihydro-benzo[2,3- b]phenazine-6,11-dione derivatives

Bioorganic & medicinal chemistry, 2003-04, Vol.11 (8), p.1709-1714

2003

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Synthesis and cytotoxicity evaluation of substituted pyridazino[4,5- b]phenazine-5,12-diones and tri/tetra-azabenzofluorene-5,6-diones

European journal of medicinal chemistry, 2007-02, Vol.42 (2), p.168-174

2007

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Novel benzoylurea derivatives as potential antitumor agents; synthesis, activities and structure-activity relationships

Archives of pharmacal research, 2002-12, Vol.25 (6), p.781-785

2002

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Synthesis and cytotoxicity evaluation of 6,11-dihydro-pyridazo- and 6,11-dihydro-pyrido[2,3- b]phenazine-6,11-diones

Bioorganic & medicinal chemistry, 2004-04, Vol.12 (7), p.1623-1628

2004

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Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC)

Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer

Design and characterization of cereblon-mediated androgen receptor proteolysis-targeting chimeras

A novel cereblon modulator for targeted protein degradation

Synthesis and cytotoxicity of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives

Structure–Activity Relationship of Oleanane Disaccharides Isolated from Akebia quinata versus Cytotoxicity against Cancer Cells and NO Inhibition

Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM)

Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5- g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition

In vivo distribution and antitumor activity of heparin-stabilized doxorubicin-loaded liposomes

Cytotoxic steroidal saponins from the rhizomes of Asparagus oligoclonos

Synthesis and structure–activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors

Discovery of aminopyridines substituted with benzoxazole as orally active c-Met kinase inhibitors

Cytotoxic Compounds from a Two-Sponge Association

3D-QSAR studies of cytotoxic heterocyclic quinones using calculated reduction potential

Synthesis, cytotoxicity, and DNA topoisomerase II inhibitory activity of benzofuroquinolinediones

Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors

Synthesis, topoisomerase I inhibition and structure-activity relationship study of 2,4,6-trisubstituted pyridine derivatives

BCNU-loaded poly( d, l-lactide-co-glycolide) wafer and antitumor activity against XF-498 human CNS tumor cells in vitro

New Bioactive Cerebrosides from Arisaema amurense

Synthesis and cytotoxicity evaluation of 2-amino- and 2-hidroxy-3-ethoxycarbonyl-N-substituted-benzo[f]indole-4,9-dione derivatives

Differential effects of the optical isomers of KR30031 on cardiotoxicity and on multidrug resistance reversal activity

Synthesis and cytotoxicity of 6,11-Dihydro-pyrido- and 6,11-Dihydro-benzo[2,3- b]phenazine-6,11-dione derivatives

Synthesis and cytotoxicity evaluation of substituted pyridazino[4,5- b]phenazine-5,12-diones and tri/tetra-azabenzofluorene-5,6-diones

Novel benzoylurea derivatives as potential antitumor agents; synthesis, activities and structure-activity relationships

Synthesis and cytotoxicity evaluation of 6,11-dihydro-pyridazo- and 6,11-dihydro-pyrido[2,3- b]phenazine-6,11-diones

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