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Site-specific protein labeling in the pharmaceutical industry: experiences from novartis drug discovery

Methods in molecular biology (Clifton, N.J.), 2015, Vol.1266, p.7

Leder, Lukas

2015

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Encoded Library Technologies as Integrated Lead Finding Platforms for Drug Discovery

Molecules (Basel, Switzerland), 2019-04, Vol.24 (8), p.1629

2019

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X‐ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan–McDermid Syndrome

ChemMedChem, 2018-09, Vol.13 (18), p.1997-2007

2018

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Abstract 1239: NVP-HDM201: Biochemical and biophysical profile of a novel highly potent and selective PPI inhibitor of p53-Mdm2

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.1239-1239

2016

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The Crystal Structure of the Ligand Binding Module of Axonin-1/TAG-1 Suggests a Zipper Mechanism for Neural Cell Adhesion

Cell, 2000-05, Vol.101 (4), p.425-433

2000

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Development of a novel Gateway-based vector system for efficient, multiparallel protein expression in Escherichia coli

Protein expression and purification, 2008-06, Vol.59 (2), p.232-241

2008

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The structure of Ca2+ sensor Case16 reveals the mechanism of reaction to low Ca2+ concentrations

Sensors (Basel, Switzerland), 2010-09, Vol.10 (9), p.8143-8160

2010

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Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches

Journal of medicinal chemistry, 2024-05, Vol.67 (10), p.8141-8160

2024

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Structural Determinants of MALT1 Protease Activity

Journal of molecular biology, 2012-05, Vol.419 (1-2), p.4-21

2012

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mRNA Display Identifies Potent, Paralog-Selective Peptidic Ligands for ARID1B

ACS chemical biology, 2024-05, Vol.19 (5), p.1142-1150

2024

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Very Rapid, Ionic Strength-Dependent Association and Folding of a Heterodimeric Leucine Zipper

Biochemistry (Easton), 1997-01, Vol.36 (1), p.204-213

1997

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Quantensimulation von relativistischen effekten mit ultrakalten atomen in variablen optischen gitterpotentialen

Leder, Lukas Martin

2016

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Spectroscopic, Calorimetric, and Kinetic Demonstration of Conformational Adaptation in Peptide-Antibody Recognition

Biochemistry (Easton), 1995-12, Vol.34 (50), p.16509-16518

1995

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Evaluation of two novel tag-based labelling technologies for site-specific modification of proteins

International journal of biological macromolecules, 2006-08, Vol.39 (1), p.66-76

2006

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Novel pharmacological insights for adenylyl cyclase 5, a gatekeeper of GPCR signaling

The FASEB journal, 2010-04, Vol.24 (S1), p.lb477-lb477

2010

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HDL-like discs for assaying membrane proteins in drug discovery

Biophysical chemistry, 2012-05, Vol.165-166, p.56-61

2012

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Synthesis and characterization of fluorescent ubiquitin derivatives as highly sensitive substrates for the deubiquitinating enzymes UCH-L3 and USP-2

Analytical biochemistry, 2005-08, Vol.343 (2), p.244-255

2005

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Three-Dimensional Structure of the Complex between a T Cell Receptor β Chain and the Superantigen Staphylococcal Enterotoxin B

Immunity (Cambridge, Mass.), 1998-12, Vol.9 (6), p.807-816

1998

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Readout technologies for highly miniaturized kinase assays applicable to high-throughput screening in a 1536-well format

Journal of biomolecular screening, 2006-09, Vol.11 (6), p.617-633

2006

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Optimization of protein expression systems for modern drug discovery

Expert review of proteomics, 2007-02, Vol.4 (1), p.67-78

2007

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Adhesion proteins for a tight neuron–electrode contact

Journal of neuroscience methods, 2001-01, Vol.104 (2), p.133-141

2001

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A mutational analysis of the binding of staphylococcal enterotoxins B and C3 to the T cell receptor beta chain and major histocompatibility complex class II

The Journal of experimental medicine, 1998-03, Vol.187 (6), p.823-833

1998

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Probing the Energetics of Antigen–Antibody Recognition by Titration Microcalorimetry

Methods (San Diego, Calif.), 1996-06, Vol.9 (3), p.533-541

1996

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New methods for efficient protein production in drug discovery

Current opinion in drug discovery & development, 2007-03, Vol.10 (2), p.193

2007

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Kreuzreakivitat und konformationelle anpassung bei antigen-antikorper reaktionen

Leder, Lukas Peter

1995

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Site-specific protein labeling in the pharmaceutical industry: experiences from novartis drug discovery

Encoded Library Technologies as Integrated Lead Finding Platforms for Drug Discovery

X‐ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan–McDermid Syndrome

Abstract 1239: NVP-HDM201: Biochemical and biophysical profile of a novel highly potent and selective PPI inhibitor of p53-Mdm2

The Crystal Structure of the Ligand Binding Module of Axonin-1/TAG-1 Suggests a Zipper Mechanism for Neural Cell Adhesion

Development of a novel Gateway-based vector system for efficient, multiparallel protein expression in Escherichia coli

The structure of Ca2+ sensor Case16 reveals the mechanism of reaction to low Ca2+ concentrations

Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches

Structural Determinants of MALT1 Protease Activity

mRNA Display Identifies Potent, Paralog-Selective Peptidic Ligands for ARID1B

Very Rapid, Ionic Strength-Dependent Association and Folding of a Heterodimeric Leucine Zipper

Quantensimulation von relativistischen effekten mit ultrakalten atomen in variablen optischen gitterpotentialen

Spectroscopic, Calorimetric, and Kinetic Demonstration of Conformational Adaptation in Peptide-Antibody Recognition

Evaluation of two novel tag-based labelling technologies for site-specific modification of proteins

Novel pharmacological insights for adenylyl cyclase 5, a gatekeeper of GPCR signaling

HDL-like discs for assaying membrane proteins in drug discovery

Synthesis and characterization of fluorescent ubiquitin derivatives as highly sensitive substrates for the deubiquitinating enzymes UCH-L3 and USP-2

Three-Dimensional Structure of the Complex between a T Cell Receptor β Chain and the Superantigen Staphylococcal Enterotoxin B

Readout technologies for highly miniaturized kinase assays applicable to high-throughput screening in a 1536-well format

Optimization of protein expression systems for modern drug discovery

Adhesion proteins for a tight neuron–electrode contact

A mutational analysis of the binding of staphylococcal enterotoxins B and C3 to the T cell receptor beta chain and major histocompatibility complex class II

Probing the Energetics of Antigen–Antibody Recognition by Titration Microcalorimetry

New methods for efficient protein production in drug discovery

Kreuzreakivitat und konformationelle anpassung bei antigen-antikorper reaktionen

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