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Glycoform-resolved pharmacokinetic studies in a rat model employing glycoengineered variants of a therapeutic monoclonal antibody

mAbs, 2021-01, Vol.13 (1), p.1865596

2021

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Internalization of therapeutic antibodies into dendritic cells as a risk factor for immunogenicity

Frontiers in immunology, 2024-08, Vol.15

2024

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Immunopurification and Mass Spectrometric Quantification of the Active Form of a Chimeric Therapeutic Antibody in Human Serum

Analytical chemistry (Washington), 2008-03, Vol.80 (5), p.1737-1745

2008

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The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance

mAbs, 2021-01, Vol.13 (1), p.1995929-1995929

2021

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Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model

mAbs, 2022, Vol.14 (1), p.2145929

2022

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ROCKETS - a novel one-for-all toolbox for light sheet microscopy in drug discovery

Frontiers in immunology, 2023-02, Vol.14, p.1034032-1034032

2023

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Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy

Molecular oncology, 2016-10, Vol.10 (8), p.1317-1329

2016

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Immunization with Hepatitis C Virus-like Particles Protects Mice from Recombinant Hepatitis C Virus-Vaccinia Infection

Proceedings of the National Academy of Sciences - PNAS, 2003-05, Vol.100 (11), p.6753-6758

2003

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Abstract 4510: RG7787 - a novel de-immunized PE based fusion protein for therapy of mesothelin-positive solid tumors

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.4510-4510

2014

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Biodistribution of Drug/ADA Complexes: The Impact of Immune Complex Formation on Antibody Distribution

The AAPS journal, 2024-03, Vol.26 (2), p.33-33, Article 33

2024

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Fibroblast Activation Protein α-Targeted CD40 Agonism Abrogates Systemic Toxicity and Enables Administration of High Doses to Induce Effective Antitumor Immunity

Clinical cancer research, 2021-07, Vol.27 (14), p.4036-4053

2021

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In Vivo Reoxidation Kinetics of Free Thiols in Multiple Domains of IgG1 Antibodies in Rats

Journal of pharmaceutical sciences, 2021-05, Vol.110 (5), p.1989-1996

2021

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Translating pharmacology models effectively to predict therapeutic benefit

Drug discovery today, 2022-06, Vol.27 (6), p.1604-1621

2022

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Comparative assessment of immune complex-mediated hypersensitivity reactions with biotherapeutics in the non-human primate: Critical parameters, safety and lessons for future studies

Regulatory toxicology and pharmacology, 2017-08, Vol.88, p.125-137

2017

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Genetic Immunization of Wild-Type and Hepatitis C Virus Transgenic Mice Reveals a Hierarchy of Cellular Immune Response and Tolerance Induction against Hepatitis C Virus Structural Proteins

Journal of Virology, 2001-12, Vol.75 (24), p.12121-12127

2001

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Abstract 2961: HLA-G-TCB (RG6353), a T cell bispecific antibody for the treatment of solid tumors in monotherapy and combination with immunomodulator agents

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.2961-2961

2023

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Vaccination trial with HPV16 L1E7 chimeric virus‐like particles in women suffering from high grade cervical intraepithelial neoplasia (CIN 2/3)

International journal of cancer, 2007-12, Vol.121 (12), p.2794-2800

2007

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Hepatitis C virus–like particles induce virus-specific humoral and cellular immune responses in mice

Hepatology (Baltimore, Md.), 2001-08, Vol.34 (2), p.417-423

2001

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Vaccine Development for Hepatitis C

Seminars in liver disease, 2000, Vol.20 (2), p.211-226

2000

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Efficacy of oncolytic herpesvirus NV1020 can be enhanced by combination with chemotherapeutics in colon carcinoma cells

Human gene therapy, 2006-12, Vol.17 (12), p.1241

2006

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Hepatitis C virus-like particles synthesized in insect cells as a potential vaccine candidate

Gastroenterology (New York, N.Y. 1943), 1999-12, Vol.117 (6), p.1397-1407

1999

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T- and B-cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus-positive blood donors without viremia

Hepatology (Baltimore, Md.), 1996-10, Vol.24 (4), p.790-795

1996

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Decreased frequency of HCV core-specific peripheral blood mononuclear cells with type 1 cytokine secretion in chronic hepatitis C

Journal of hepatology, 1999-12, Vol.31 (6), p.971-978

1999

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CD30 induction and cytokine profiles in hepatitis C virus core-specific peripheral blood T lymphocytes

The Journal of immunology (1950), 1997-07, Vol.159 (2), p.1012

1997

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Glycoform-resolved pharmacokinetic studies in a rat model employing glycoengineered variants of a therapeutic monoclonal antibody

Internalization of therapeutic antibodies into dendritic cells as a risk factor for immunogenicity

Immunopurification and Mass Spectrometric Quantification of the Active Form of a Chimeric Therapeutic Antibody in Human Serum

The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance

Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model

ROCKETS - a novel one-for-all toolbox for light sheet microscopy in drug discovery

Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy

Immunization with Hepatitis C Virus-like Particles Protects Mice from Recombinant Hepatitis C Virus-Vaccinia Infection

Abstract 4510: RG7787 - a novel de-immunized PE based fusion protein for therapy of mesothelin-positive solid tumors

Biodistribution of Drug/ADA Complexes: The Impact of Immune Complex Formation on Antibody Distribution

Fibroblast Activation Protein α-Targeted CD40 Agonism Abrogates Systemic Toxicity and Enables Administration of High Doses to Induce Effective Antitumor Immunity

In Vivo Reoxidation Kinetics of Free Thiols in Multiple Domains of IgG1 Antibodies in Rats

Translating pharmacology models effectively to predict therapeutic benefit

CD19-CD28: an affinity-optimized CD28 agonist for combination with glofitamab (CD20-TCB) as off-the-shelf immunotherapy

Comparative assessment of immune complex-mediated hypersensitivity reactions with biotherapeutics in the non-human primate: Critical parameters, safety and lessons for future studies

Genetic Immunization of Wild-Type and Hepatitis C Virus Transgenic Mice Reveals a Hierarchy of Cellular Immune Response and Tolerance Induction against Hepatitis C Virus Structural Proteins

Abstract 2961: HLA-G-TCB (RG6353), a T cell bispecific antibody for the treatment of solid tumors in monotherapy and combination with immunomodulator agents

Vaccination trial with HPV16 L1E7 chimeric virus‐like particles in women suffering from high grade cervical intraepithelial neoplasia (CIN 2/3)

Hepatitis C virus–like particles induce virus-specific humoral and cellular immune responses in mice

Vaccine Development for Hepatitis C

Efficacy of oncolytic herpesvirus NV1020 can be enhanced by combination with chemotherapeutics in colon carcinoma cells

Hepatitis C virus-like particles synthesized in insect cells as a potential vaccine candidate

T- and B-cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus-positive blood donors without viremia

Decreased frequency of HCV core-specific peripheral blood mononuclear cells with type 1 cytokine secretion in chronic hepatitis C

CD30 induction and cytokine profiles in hepatitis C virus core-specific peripheral blood T lymphocytes

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