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Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs

Journal of applied toxicology, 2016-06, Vol.36 (6), p.752-768

2016

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Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering

Current drug metabolism, 2013-11, Vol.14 (9), p.946-968

2013

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Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis

Toxicology and applied pharmacology, 2016-07, Vol.302, p.1-9

2016

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Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing

Toxicological sciences, 2016-07, Vol.152 (1), p.214-229

2016

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Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs

Toxicological sciences, 2012-05, Vol.127 (1), p.187-198

2012

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LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells

Electrophoresis, 2015-09, Vol.36 (18), p.2294-2302

2015

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Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies

Analytical and bioanalytical chemistry, 2010-03, Vol.396 (6), p.2251-2263

2010

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High-content screening technology for studying drug-induced hepatotoxicity in cell models

Archives of toxicology, 2015-07, Vol.89 (7), p.1007-1022

2015

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Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems

Food and chemical toxicology, 2018-10, Vol.120, p.196-212

2018

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Induced pluripotent stem cells for the treatment of liver diseases: challenges and perspectives from a clinical viewpoint

Annals of translational medicine, 2020-04, Vol.8 (8), p.566-566

2020

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Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury

Archives of toxicology, 2018-01, Vol.92 (1), p.383-399

2018

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Competency of different cell models to predict human hepatotoxic drugs

Expert opinion on drug metabolism & toxicology, 2014-11, Vol.10 (11), p.1553-1568

2014

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High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay

Journal of biomolecular screening, 2012-03, Vol.17 (3), p.394-400

2012

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Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing

Expert opinion on drug metabolism & toxicology, 2017-02, Vol.13 (2), p.137-148

2017

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Transcriptional regulation and expression of CYP3A4 in hepatocytes

Current drug metabolism, 2007-02, Vol.8 (2), p.185-194

2007

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Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile

Chemico-biological interactions, 2010-03, Vol.184 (3), p.376-387

2010

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Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts

Drug metabolism and disposition, 2006-09, Vol.34 (9), p.1556-1562

2006

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HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved

Archives of toxicology, 2013-06, Vol.87 (6), p.1115-1127

2013

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Human hepatocytes in primary culture: the choice to investigate drug metabolism in man

Current drug metabolism, 2004-10, Vol.5 (5), p.443-462

2004

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Neonatal Livers: A Source for the Isolation of Good-Performing Hepatocytes for Cell Transplantation

Cell transplantation, 2014-01, Vol.23 (10), p.1229-1242

2014

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A simple transcriptomic signature able to predict drug-induced hepatic steatosis

Archives of toxicology, 2014-04, Vol.88 (4), p.967-982

2014

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High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins

Archives of toxicology, 2015-10, Vol.89 (10), p.1847-1860

2015

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Multiparametric evaluation of the cytoprotective effect of the Mangifera indica L. stem bark extract and mangiferin in HepG2 cells

Journal of pharmacy and pharmacology, 2013-07, Vol.65 (7), p.1073-1082

2013

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Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure

Cytotherapy (Oxford, England), 2020-02, Vol.22 (2), p.114-121

2020

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HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved

Archives of toxicology, 2013-06, Vol.87 (6), p.1115-1127

2013

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Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs

Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering

Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis

Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing

Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs

LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells

Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies

High-content screening technology for studying drug-induced hepatotoxicity in cell models

Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems

Induced pluripotent stem cells for the treatment of liver diseases: challenges and perspectives from a clinical viewpoint

Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury

Competency of different cell models to predict human hepatotoxic drugs

High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay

Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing

Transcriptional regulation and expression of CYP3A4 in hepatocytes

Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile

Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts

HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved

Human hepatocytes in primary culture: the choice to investigate drug metabolism in man

Neonatal Livers: A Source for the Isolation of Good-Performing Hepatocytes for Cell Transplantation

A simple transcriptomic signature able to predict drug-induced hepatic steatosis

High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins

Multiparametric evaluation of the cytoprotective effect of the Mangifera indica L. stem bark extract and mangiferin in HepG2 cells

Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure

HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved

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