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Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia

The New England journal of medicine, 2020-08, Vol.383 (7), p.617-629

2020

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BH3-only proteins: Orchestrators of apoptosis

Biochimica et biophysica acta, 2011-04, Vol.1813 (4), p.508-520

2011

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Identification of Chemotherapy-Induced Leukemic-Regenerating Cells Reveals a Transient Vulnerability of Human AML Recurrence

Cancer cell, 2018-09, Vol.34 (3), p.483-498.e5

2018

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Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance

EMBO reports, 2018-09, Vol.19 (9), p.n/a

2018

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Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax

Molecular cell, 2020-02, Vol.77 (4), p.901-912.e9

2020

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Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

Cell, 2008-12, Vol.135 (6), p.1074-1084

2008

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Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

eLife, 2019-03, Vol.8

2019

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The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

Nature (London), 2014-07, Vol.511 (7507), p.90-93

2014

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Examining the Molecular Mechanism of Bcl-2 Family Proteins at Membranes by Fluorescence Spectroscopy

Methods in Enzymology, 2014, Vol.544, p.1-23

2014

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Bcl-XL inhibits membrane permeabilization by competing with Bax

PLoS biology, 2008-06, Vol.6 (6), p.e147

2008

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The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells

eLife, 2020-01, Vol.9

2020

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Differences in the Mechanisms of Proapoptotic BH3 Proteins Binding to Bcl-XL and Bcl-2 Quantified in Live MCF-7 Cells

Molecular cell, 2012-03, Vol.45 (6), p.754-763

2012

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The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes

eLife, 2023-04, Vol.12

2023

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Bcl-2 changes conformation to inhibit Bax oligomerization

The EMBO journal, 2006-06, Vol.25 (11), p.2287-2296

2006

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Multiple post-translational modifications regulate E-cadherin transport during apoptosis

Journal of cell science, 2012-06, Vol.125 (Pt 11), p.2615-2625

2012

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High transferrin saturation predicts inferior clinical outcomes in patients with myelodysplastic syndromes

Haematologica (Roma), 2023-02, Vol.108 (2), p.532-542

2023

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Survival outcomes and clinical benefit in patients with acute myeloid leukemia treated with glasdegib and low-dose cytarabine according to response to therapy

Journal of hematology and oncology, 2020-07, Vol.13 (1), p.92-92, Article 92

2020

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Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET

Cell cycle (Georgetown, Tex.), 2012-10, Vol.11 (19), p.3536-3542

2012

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Drugs targeting Bcl-2 family members as an emerging strategy in cancer

Expert reviews in molecular medicine, 2010-09, Vol.12, p.e28, Article e28

2010

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Real-World Treatment Patterns and Clinical Outcomes in Canadian Patients with AML Unfit for First-Line Intensive Chemotherapy

Current oncology (Toronto), 2022-09, Vol.29 (10), p.6794-6806

2022

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Consensus Recommendations for MRD Testing in Adult B-Cell Acute Lymphoblastic Leukemia in Ontario

Current oncology (Toronto), 2021-03, Vol.28 (2), p.1376-1387

2021

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Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis

The FASEB journal, 2000-04, Vol.14 (5), p.729-739

2000

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Interaction with a Membrane Surface Triggers a Reversible Conformational Change in Bax Normally Associated with Induction of Apoptosis

The Journal of biological chemistry, 2003-12, Vol.278 (49), p.48935-48941

2003

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Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line

BMC cancer, 2006-08, Vol.6 (1), p.213-213, Article 213

2006

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The Proapoptotic Protein tBid Forms Both Superficially Bound and Membrane-Inserted Oligomers

Biophysical journal, 2014-05, Vol.106 (10), p.2085-2095

2014

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Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia

BH3-only proteins: Orchestrators of apoptosis

Identification of Chemotherapy-Induced Leukemic-Regenerating Cells Reveals a Transient Vulnerability of Human AML Recurrence

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance

Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

Examining the Molecular Mechanism of Bcl-2 Family Proteins at Membranes by Fluorescence Spectroscopy

Bcl-XL inhibits membrane permeabilization by competing with Bax

The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells

Differences in the Mechanisms of Proapoptotic BH3 Proteins Binding to Bcl-XL and Bcl-2 Quantified in Live MCF-7 Cells

The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes

Bcl-2 changes conformation to inhibit Bax oligomerization

Multiple post-translational modifications regulate E-cadherin transport during apoptosis

High transferrin saturation predicts inferior clinical outcomes in patients with myelodysplastic syndromes

Survival outcomes and clinical benefit in patients with acute myeloid leukemia treated with glasdegib and low-dose cytarabine according to response to therapy

Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET

Drugs targeting Bcl-2 family members as an emerging strategy in cancer

Real-World Treatment Patterns and Clinical Outcomes in Canadian Patients with AML Unfit for First-Line Intensive Chemotherapy

Consensus Recommendations for MRD Testing in Adult B-Cell Acute Lymphoblastic Leukemia in Ontario

Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis

Interaction with a Membrane Surface Triggers a Reversible Conformational Change in Bax Normally Associated with Induction of Apoptosis

Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line

The Proapoptotic Protein tBid Forms Both Superficially Bound and Membrane-Inserted Oligomers

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