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The folate receptor as a rational therapeutic target for personalized cancer treatment

Drug resistance updates, 2014-10, Vol.17 (4), p.89-95

2014

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Engineering Folate–Drug Conjugates to Target Cancer: From Chemistry to Clinic

Bioconjugate chemistry, 2012-07, Vol.23 (7), p.1357-1369

2012

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Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters

Nature communications, 2019-06, Vol.10 (1), p.2681-11, Article 2681

2019

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Vintafolide: a novel targeted therapy for the treatment of folate receptor expressing tumors

Therapeutic Advances in Medical Oncology, 2015-07, Vol.7 (4), p.206-218

2015

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Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases

Journal of experimental & clinical cancer research, 2019-03, Vol.38 (1), p.125-12, Article 125

2019

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Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay

Analytical biochemistry, 2005-03, Vol.338 (2), p.284-293

2005

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PRECEDENT: A Randomized Phase II Trial Comparing Vintafolide (EC145) and Pegylated Liposomal Doxorubicin (PLD) in Combination Versus PLD Alone in Patients With Platinum-Resistant Ovarian Cancer

Journal of clinical oncology, 2013-12, Vol.31 (35), p.4400-4406

2013

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Folate-targeted chemotherapy

Advanced drug delivery reviews, 2004-04, Vol.56 (8), p.1127-1141

2004

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Folate-Conjugated Rapamycin Slows Progression of Polycystic Kidney Disease

Journal of the American Society of Nephrology, 2012-10, Vol.23 (10), p.1674-1681

2012

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Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic

Scientific reports, 2018-06, Vol.8 (1), p.8943-10, Article 8943

2018

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Carbonic Anhydrase IX-Targeted Near-Infrared Dye for Fluorescence Imaging of Hypoxic Tumors

Bioconjugate chemistry, 2018-10, Vol.29 (10), p.3320-3331

2018

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Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate

Bioconjugate chemistry, 2019-06, Vol.30 (6), p.1805-1813

2019

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Comparison of folate-conjugated rapamycin versus unconjugated rapamycin in an orthologous mouse model of polycystic kidney disease

American journal of physiology. Renal physiology, 2018-08, Vol.315 (2), p.F395-F405

2018

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Folate-mediated targeting: from diagnostics to drug and gene delivery

Drug Discovery Today, 2001, Vol.6 (1), p.44-51

2001

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Phase I Study of Folate Conjugate EC145 (Vintafolide) in Patients With Refractory Solid Tumors

Journal of clinical oncology, 2012-11, Vol.30 (32), p.4011-4016

2012

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Preclinical Evaluation of Bispecific Adaptor Molecule Controlled Folate Receptor CAR-T Cell Therapy With Special Focus on Pediatric Malignancies

Frontiers in oncology, 2019-03, Vol.9, p.151-151

2019

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Preclinical evaluation of EC145, a folate-Vinca alkaloid conjugate

Cancer research (Chicago, Ill.), 2007-05, Vol.67 (9), p.4434-4442

2007

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Folate-targeted drug strategies for the treatment of cancer

Current opinion in investigational drugs (London, England : 2000), 2008-12, Vol.9 (12), p.1277

Leamon, Christopher P

2008

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Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent

Scientific reports, 2020-07, Vol.10 (1), p.12772-13, Article 12772

2020

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Preclinical Antitumor Activity of a Novel Folate-Targeted Dual Drug Conjugate

Molecular pharmaceutics, 2007-09, Vol.4 (5), p.659-667

2007

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Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate

Arthritis research & therapy, 2011-04, Vol.13 (2), p.R56-R56

2011

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Folate receptor-targeted immunotherapy of cancer: mechanism and therapeutic potential

Advanced drug delivery reviews, 2004-04, Vol.56 (8), p.1161-1176

2004

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Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis

Toxicology and applied pharmacology, 2019-04, Vol.368, p.49-54

2019

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Phase I/II clinical trial of the targeted chemotherapeutic drug, folate-tubulysin, in dogs with naturally-occurring invasive urothelial carcinoma

Oncotarget, 2018-12, Vol.9 (97), p.37042-37053

2018

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Impact of high and low folate diets on tissue folate receptor levels and antitumor responses toward folate-drug conjugates

The Journal of pharmacology and experimental therapeutics, 2008-12, Vol.327 (3), p.918-925

2008

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The folate receptor as a rational therapeutic target for personalized cancer treatment

Engineering Folate–Drug Conjugates to Target Cancer: From Chemistry to Clinic

Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters

Vintafolide: a novel targeted therapy for the treatment of folate receptor expressing tumors

Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases

Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay

PRECEDENT: A Randomized Phase II Trial Comparing Vintafolide (EC145) and Pegylated Liposomal Doxorubicin (PLD) in Combination Versus PLD Alone in Patients With Platinum-Resistant Ovarian Cancer

Folate-targeted chemotherapy

Folate-Conjugated Rapamycin Slows Progression of Polycystic Kidney Disease

Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic

Carbonic Anhydrase IX-Targeted Near-Infrared Dye for Fluorescence Imaging of Hypoxic Tumors

Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate

Comparison of folate-conjugated rapamycin versus unconjugated rapamycin in an orthologous mouse model of polycystic kidney disease

Folate-mediated targeting: from diagnostics to drug and gene delivery

Phase I Study of Folate Conjugate EC145 (Vintafolide) in Patients With Refractory Solid Tumors

Preclinical Evaluation of Bispecific Adaptor Molecule Controlled Folate Receptor CAR-T Cell Therapy With Special Focus on Pediatric Malignancies

Preclinical evaluation of EC145, a folate-Vinca alkaloid conjugate

Folate-targeted drug strategies for the treatment of cancer

Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent

Preclinical Antitumor Activity of a Novel Folate-Targeted Dual Drug Conjugate

Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate

Folate receptor-targeted immunotherapy of cancer: mechanism and therapeutic potential

Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis

Phase I/II clinical trial of the targeted chemotherapeutic drug, folate-tubulysin, in dogs with naturally-occurring invasive urothelial carcinoma

Impact of high and low folate diets on tissue folate receptor levels and antitumor responses toward folate-drug conjugates

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