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Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia

Oncogene, 2017-11, Vol.36 (46), p.6462-6471

2017

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Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model

Oncogene, 2013-02, Vol.32 (8), p.961-967

2013

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Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia

Oncogene, 2012-07, Vol.31 (27), p.3213-3222

2012

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Insulin-Like Growth Factor I Is Required for Vessel Remodeling in the Adult Brain

Proceedings of the National Academy of Sciences - PNAS, 2004-06, Vol.101 (26), p.9833-9838

2004

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Silencing vimentin expression decreases pulmonary metastases in a pre-diabetic mouse model of mammary tumor progression

Oncogene, 2017-03, Vol.36 (10), p.1394-1403

2017

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Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects

Molecular psychiatry, 2007-12, Vol.12 (12), p.1118-1128

2007

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Serum insulin-like growth factor I regulates brain amyloid-β levels

Nature medicine, 2002-12, Vol.8 (12), p.1390-1397

2002

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Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum

Cell death and differentiation, 2008-08, Vol.15 (8), p.1304-1317

2008

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The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer

Oncogenesis (New York, NY), 2015-06, Vol.4 (6), p.e156-e156

2015

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Minireview: tissue-specific versus generalized gene targeting of the igf1 and igf1r genes and their roles in insulin-like growth factor physiology

Endocrinology (Philadelphia), 2001-05, Vol.142 (5), p.1685-1688

2001

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Update on diabetes mellitus: prevention, treatment, and association with oral diseases

Oral diseases, 2008-03, Vol.14 (2), p.105-114

2008

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Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence

Experimental and clinical endocrinology & diabetes, 2008-09, Vol.116 Suppl 1 (S 01), p.S4-S6

2008

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MKR mice have increased dynamic glucose disposal despite metabolic inflexibility, and hepatic and peripheral insulin insensitivity

Diabetologia, 2010-10, Vol.53 (10), p.2224-2232

2010

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Pathophysiology of the Metabolic Syndrome: Implications for the Cardiometabolic Risks Associated With Type 2 Diabetes

The American journal of the medical sciences, 2012, Vol.343 (1), p.13-16

Leroith, Derek, MD, PhD

2012

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The Potentiation of Estrogen on Insulin-like Growth Factor I Action in MCF-7 Human Breast Cancer Cells Includes Cell Cycle Components

The Journal of biological chemistry, 2000-11, Vol.275 (46), p.35893-35901

2000

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β-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities

The American journal of medicine, 2002-10, Vol.113 (6), p.3-11

LeRoith, Derek

2002

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Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes

Diabetologia, 2006-01, Vol.49 (1), p.90-99

2006

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Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

Cell, 2019-08, Vol.178 (5), p.1102-1114.e17

2019

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PL12 Growth hormone and IGF-1 in mouse models of growth and metabolism

Growth hormone & IGF research, 2012-10, Vol.22, p.S28-S28

2012

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The Role of the Insulin-like Growth Factor System in Human Cancer

Advances in Cancer Research, 1996, Vol.68, p.183-223

1996

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Effect of online diabetes training for hospitalists on inpatient glycaemia

Diabetic medicine, 2013-08, Vol.30 (8), p.994-998

2013

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Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation

Oncogene, 2009-10, Vol.28 (39), p.3477-3486

2009

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Wild-Type and Mutant p53 Differentially Regulate Transcription of the Insulin-Like Growth Factor I Receptor Gene

Proceedings of the National Academy of Sciences - PNAS, 1996-08, Vol.93 (16), p.8318-8323

1996

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The effect of leptin administration on mammary tumor growth in diabetic mice

Hormone and metabolic research, 2013-09, Vol.45 (9), p.655-659

2013

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Emerging Concepts in the Role of IGFs and Cancer

Hormone and metabolic research, 2003-11, Vol.35 (11/12), p.649-650

LeRoith, D.

2003

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Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia

Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model

Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia

Insulin-Like Growth Factor I Is Required for Vessel Remodeling in the Adult Brain

Silencing vimentin expression decreases pulmonary metastases in a pre-diabetic mouse model of mammary tumor progression

Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects

Serum insulin-like growth factor I regulates brain amyloid-β levels

Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum

The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer

Minireview: tissue-specific versus generalized gene targeting of the igf1 and igf1r genes and their roles in insulin-like growth factor physiology

Update on diabetes mellitus: prevention, treatment, and association with oral diseases

Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence

MKR mice have increased dynamic glucose disposal despite metabolic inflexibility, and hepatic and peripheral insulin insensitivity

Pathophysiology of the Metabolic Syndrome: Implications for the Cardiometabolic Risks Associated With Type 2 Diabetes

The Potentiation of Estrogen on Insulin-like Growth Factor I Action in MCF-7 Human Breast Cancer Cells Includes Cell Cycle Components

β-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities

Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

PL12 Growth hormone and IGF-1 in mouse models of growth and metabolism

The Role of the Insulin-like Growth Factor System in Human Cancer

Effect of online diabetes training for hospitalists on inpatient glycaemia

Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation

Wild-Type and Mutant p53 Differentially Regulate Transcription of the Insulin-Like Growth Factor I Receptor Gene

The effect of leptin administration on mammary tumor growth in diabetic mice

Emerging Concepts in the Role of IGFs and Cancer

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