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Therapeutic potential of Nlrp1 inflammasome, Caspase-1, or Caspase-6 against Alzheimer disease cognitive impairment

Cell death and differentiation, 2022-03, Vol.29 (3), p.657-669

2022

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Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice

Cell death & disease, 2022-10, Vol.13 (10), p.864-864, Article 864

2022

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Caspase-6 as a novel early target in the treatment of Alzheimer's disease

The European journal of neuroscience, 2013-06, Vol.37 (12), p.2005-2018

LeBlanc, Andrea C.

2013

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Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer

Breast cancer research : BCR, 2013-03, Vol.15 (2), p.R22-R22, Article R22

2013

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Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits

Cell death & disease, 2021-03, Vol.12 (3), p.227-227, Article 227

2021

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The role of apoptotic pathways in Alzheimer's disease neurodegeneration and cell death

Current Alzheimer research, 2005-10, Vol.2 (4), p.389-402

LeBlanc, Andrea C

2005

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Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells

Biochimica et biophysica acta, 2009-03, Vol.1793 (3), p.592-601

2009

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Novel therapeutic target against Alzheimer

Oncotarget, 2017-07, Vol.8 (30), p.48529-48530

LeBlanc, Andrea C

2017

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Targets of Caspase-6 Activity in Human Neurons and Alzheimer Disease

Molecular & cellular proteomics, 2008-08, Vol.7 (8), p.1541-1555

2008

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Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine

Scientific reports, 2015-09, Vol.5 (1), p.13730-13730, Article 13730

2015

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Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

Nature communications, 2018-09, Vol.9 (1), p.3916-14, Article 3916

2018

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Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration

Scientific reports, 2021-06, Vol.11 (1), p.12695-12695, Article 12695

2021

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Luman contributes to brefeldin A-induced prion protein gene expression by interacting with the ERSE26 element

Scientific reports, 2017-02, Vol.7 (1), p.42285-42285, Article 42285

2017

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Caspase-6 activity predicts lower episodic memory ability in aged individuals

Neurobiology of aging, 2013-07, Vol.34 (7), p.1815-1824

2013

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Cyclin-dependent Kinase 5 Phosphorylation of Familial Prion Protein Mutants Exacerbates Conversion into Amyloid Structure

The Journal of biological chemistry, 2015-02, Vol.290 (9), p.5759-5771

2015

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Active Caspase-6 and Caspase-6-Cleaved Tau in Neuropil Threads, Neuritic Plaques, and Neurofibrillary Tangles of Alzheimer's Disease

The American journal of pathology, 2004-08, Vol.165 (2), p.523-531

2004

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Author Correction: Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration

Scientific reports, 2021-08, Vol.11 (1), p.16151-16151, Article 16151

2021

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Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice

Acta neuropathologica communications, 2019-12, Vol.7 (1), p.210-210, Article 210

2019

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Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice

Molecular neurodegeneration, 2017-02, Vol.12 (1), p.22, Article 22

2017

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Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury

Acta neuropathologica communications, 2014-02, Vol.2 (1), p.16-16, Article 16

2014

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Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging

Nature communications, 2020-09, Vol.11 (1), p.4571-4571, Article 4571

2020

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Cerebrospinal Fluid Tau Cleaved by Caspase-6 Reflects Brain Levels and Cognition in Aging and Alzheimer Disease

Journal of neuropathology and experimental neurology, 2013-09, Vol.72 (9), p.824-832

2013

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Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein or Presenilin I or Presenilin II Mutations

Journal of neuropathology and experimental neurology, 2009-12, Vol.68 (12), p.1282-1293

2009

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Identification of Allosteric Inhibitors against Active Caspase-6

Scientific reports, 2019-04, Vol.9 (1), p.5504, Article 5504

2019

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Familial prion protein mutants inhibit Hrd1-mediated retrotranslocation of misfolded proteins by depleting misfolded protein sensor BiP

Human molecular genetics, 2016-03, Vol.25 (5), p.976-988

2016

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Therapeutic potential of Nlrp1 inflammasome, Caspase-1, or Caspase-6 against Alzheimer disease cognitive impairment

Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice

Caspase-6 as a novel early target in the treatment of Alzheimer's disease

Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer

Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits

The role of apoptotic pathways in Alzheimer's disease neurodegeneration and cell death

Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells

Novel therapeutic target against Alzheimer

Targets of Caspase-6 Activity in Human Neurons and Alzheimer Disease

Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration

Luman contributes to brefeldin A-induced prion protein gene expression by interacting with the ERSE26 element

Caspase-6 activity predicts lower episodic memory ability in aged individuals

Cyclin-dependent Kinase 5 Phosphorylation of Familial Prion Protein Mutants Exacerbates Conversion into Amyloid Structure

Active Caspase-6 and Caspase-6-Cleaved Tau in Neuropil Threads, Neuritic Plaques, and Neurofibrillary Tangles of Alzheimer's Disease

Author Correction: Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration

Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice

Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice

Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury

Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging

Cerebrospinal Fluid Tau Cleaved by Caspase-6 Reflects Brain Levels and Cognition in Aging and Alzheimer Disease

Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein or Presenilin I or Presenilin II Mutations

Identification of Allosteric Inhibitors against Active Caspase-6

Familial prion protein mutants inhibit Hrd1-mediated retrotranslocation of misfolded proteins by depleting misfolded protein sensor BiP

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