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Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

Nature communications, 2018-09, Vol.9 (1), p.3916-14, Article 3916

2018

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Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging

Nature communications, 2020-09, Vol.11 (1), p.4571-4571, Article 4571

2020

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Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6

Cell death and differentiation, 2018-07, Vol.25 (7), p.1319-1335

2018

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Hereditary Inclusion Body Myopathy-Linked p97/VCP Mutations in the NH2 Domain and the D1 Ring Modulate p97/VCP ATPase Activity and D2 Ring Conformation

Molecular and Cellular Biology, 2009-08, Vol.29 (16), p.4484-4494

2009

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Activation of Caspase-6 in Aging and Mild Cognitive Impairment

The American journal of pathology, 2007-04, Vol.170 (4), p.1200-1209

2007

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Publisher Correction: Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging

Nature communications, 2021-04, Vol.12 (1), p.2271-2271, Article 2271

2021

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Expression and activation of caspase-6 in human fetal and adult tissues

PloS one, 2013-11, Vol.8 (11), p.e79313-e79313

2013

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Identification of a Novel Endoplasmic Reticulum Stress Response Element Regulated by XBP1

The Journal of biological chemistry, 2013-07, Vol.288 (28), p.20378-20391

2013

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Stem Cell-Derived Neurons as Cellular Models of Sporadic Alzheimer's Disease

Journal of Alzheimer's disease, 2019-01, Vol.67 (3), p.893-910

2019

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Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation

The Journal of neuroscience, 2010-04, Vol.30 (17), p.6132-6142

2010

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Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent

PloS one, 2014-12, Vol.9 (12), p.e114270

2014

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The Consortium for the early identification of Alzheimer's disease–Quebec (CIMA-Q)

Alzheimer's & dementia : diagnosis, assessment & disease monitoring, 2019-12, Vol.11 (1), p.787-796

2019

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Neuroprotective functions of prion protein

Journal of neuroscience research, 2004-01, Vol.75 (2), p.153-161

2004

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Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice

Cell death & disease, 2022-10, Vol.13 (10), p.864-864, Article 864

2022

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Therapeutic potential of Nlrp1 inflammasome, Caspase-1, or Caspase-6 against Alzheimer disease cognitive impairment

Cell death and differentiation, 2022-03, Vol.29 (3), p.657-669

2022

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Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits

Cell death & disease, 2021-03, Vol.12 (3), p.227-227, Article 227

2021

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Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer

Breast cancer research : BCR, 2013-03, Vol.15 (2), p.R22-R22, Article R22

2013

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Loss of anti-Bax function in Gerstmann-Sträussler-Scheinker syndrome-associated prion protein mutants

PloS one, 2009-08, Vol.4 (8), p.e6647-e6647

2009

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Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells

Biochimica et biophysica acta, 2009-03, Vol.1793 (3), p.592-601

2009

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Targets of Caspase-6 Activity in Human Neurons and Alzheimer Disease

Molecular & cellular proteomics, 2008-08, Vol.7 (8), p.1541-1555

2008

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Luman contributes to brefeldin A-induced prion protein gene expression by interacting with the ERSE26 element

Scientific reports, 2017-02, Vol.7 (1), p.42285-42285, Article 42285

2017

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Cellular prion protein neuroprotective function: Implications in prion diseases

Journal of molecular medicine (Berlin, Germany), 2005, Vol.83 (1), p.3-11

2005

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Cyclin-dependent Kinase 5 Phosphorylation of Familial Prion Protein Mutants Exacerbates Conversion into Amyloid Structure

The Journal of biological chemistry, 2015-02, Vol.290 (9), p.5759-5771

2015

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Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration

Scientific reports, 2021-06, Vol.11 (1), p.12695-12695, Article 12695

2021

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Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein or Presenilin I or Presenilin II Mutations

Journal of neuropathology and experimental neurology, 2009-12, Vol.68 (12), p.1282-1293

2009

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Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging

Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6

Hereditary Inclusion Body Myopathy-Linked p97/VCP Mutations in the NH2 Domain and the D1 Ring Modulate p97/VCP ATPase Activity and D2 Ring Conformation

Activation of Caspase-6 in Aging and Mild Cognitive Impairment

Publisher Correction: Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging

Expression and activation of caspase-6 in human fetal and adult tissues

Identification of a Novel Endoplasmic Reticulum Stress Response Element Regulated by XBP1

Stem Cell-Derived Neurons as Cellular Models of Sporadic Alzheimer's Disease

Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation

Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent

The Consortium for the early identification of Alzheimer's disease–Quebec (CIMA-Q)

Neuroprotective functions of prion protein

Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice

Therapeutic potential of Nlrp1 inflammasome, Caspase-1, or Caspase-6 against Alzheimer disease cognitive impairment

Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits

Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer

Loss of anti-Bax function in Gerstmann-Sträussler-Scheinker syndrome-associated prion protein mutants

Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells

Targets of Caspase-6 Activity in Human Neurons and Alzheimer Disease

Luman contributes to brefeldin A-induced prion protein gene expression by interacting with the ERSE26 element

Cellular prion protein neuroprotective function: Implications in prion diseases

Cyclin-dependent Kinase 5 Phosphorylation of Familial Prion Protein Mutants Exacerbates Conversion into Amyloid Structure

Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration

Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein or Presenilin I or Presenilin II Mutations

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