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Contributions of inflammation and tumor microenvironment to neurofibroma tumorigenesis

The Journal of clinical investigation, 2018-07, Vol.128 (7), p.2848-2861

2018

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Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1

Nature communications, 2022-05, Vol.13 (1), p.2785-2785, Article 2785

2022

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Cells of Origin in the Embryonic Nerve Roots for NF1-Associated Plexiform Neurofibroma

Cancer cell, 2014-11, Vol.26 (5), p.695-706

2014

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CXCR4/CXCL12 Mediate Autocrine Cell- Cycle Progression in NF1-Associated Malignant Peripheral Nerve Sheath Tumors

Cell, 2013-02, Vol.152 (5), p.1077-1090

2013

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Basement membrane proteins in extracellular matrix characterize NF1 neurofibroma development and response to MEK inhibitor

The Journal of clinical investigation, 2023-06, Vol.133 (12), p.1-15

2023

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NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation

Nature communications, 2018-11, Vol.9 (1), p.5014-11, Article 5014

2018

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Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway

Cancer discovery, 2019-01, Vol.9 (1), p.114-129

2019

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BET Bromodomain Inhibition Triggers Apoptosis of NF1-Associated Malignant Peripheral Nerve Sheath Tumors through Bim Induction

Cell reports (Cambridge), 2014-01, Vol.6 (1), p.81-92

2014

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Susceptible Stages in Schwann Cells for NF1-Associated Plexiform Neurofibroma Development

Cancer research (Chicago, Ill.), 2011-07, Vol.71 (13), p.4686-4695

2011

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Stem cell modeling of nervous system tumors

Disease models & mechanisms, 2024-02, Vol.17 (2)

2024

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Human cutaneous neurofibroma matrisome revealed by single-cell RNA sequencing

Acta neuropathologica communications, 2021-01, Vol.9 (1), p.11-11, Article 11

2021

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Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells

PLoS genetics, 2008-12, Vol.4 (12), p.e1000298-e1000298

2008

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Training Physician‒Scientists for Careers in Investigative Dermatology

JID innovations, 2022-01, Vol.2 (1), p.100061-100061, Article 100061

2022

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Cell of Origin and Microenvironment Contribution for NF1-Associated Dermal Neurofibromas

Cell stem cell, 2009-05, Vol.4 (5), p.453-463

2009

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Malignant peripheral nerve sheath tumor: models, biology, and translation

Oncogene, 2022-04, Vol.41 (17), p.2405-2421

2022

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Epithelial stem cell homeostasis in Meibomian gland development, dysfunction, and dry eye disease

JCI insight, 2021-10, Vol.6 (20)

2021

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Tumorigenesis in neurofibromatosis type 1: role of the microenvironment

Oncogene, 2021-09, Vol.40 (39), p.5781-5787

2021

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Insights into the Pathogenesis of NF1-Associated Neoplasms

JID innovations, 2021-09, Vol.1 (3), p.100044, Article 100044

2021

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Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins

The Journal of clinical investigation, 2021-01, Vol.131 (1)

2021

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Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling

JCI insight, 2020-10, Vol.5 (20)

2020

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Neurofibromin and suppression of tumorigenesis: beyond the GAP

Oncogene, 2022-02, Vol.41 (9), p.1235-1251

2022

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Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A

Science (American Association for the Advancement of Science), 2001-07, Vol.293 (5530), p.702-705

2001

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Association of plexiform and diffuse neurofibromas with malignant peripheral nerve sheath tumor in NF I patients: a whole-body MRI assessment

Skeletal radiology, 2024-04, Vol.53 (4), p.769-777

2024

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Diffusion-weighted imaging and diffusion tensor imaging as adjuncts to conventional MRI for the diagnosis and management of peripheral nerve sheath tumors: current perspectives and future directions

European radiology, 2019-08, Vol.29 (8), p.4123-4132

2019

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STING activation reprograms the microenvironment to sensitize NF1-related malignant peripheral nerve sheath tumors for immunotherapy

The Journal of clinical investigation, 2024-05, Vol.134 (10), p.1-13

2024

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Contributions of inflammation and tumor microenvironment to neurofibroma tumorigenesis

Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1

Cells of Origin in the Embryonic Nerve Roots for NF1-Associated Plexiform Neurofibroma

CXCR4/CXCL12 Mediate Autocrine Cell- Cycle Progression in NF1-Associated Malignant Peripheral Nerve Sheath Tumors

Basement membrane proteins in extracellular matrix characterize NF1 neurofibroma development and response to MEK inhibitor

NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation

Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway

BET Bromodomain Inhibition Triggers Apoptosis of NF1-Associated Malignant Peripheral Nerve Sheath Tumors through Bim Induction

Susceptible Stages in Schwann Cells for NF1-Associated Plexiform Neurofibroma Development

Stem cell modeling of nervous system tumors

Human cutaneous neurofibroma matrisome revealed by single-cell RNA sequencing

Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells

Training Physician‒Scientists for Careers in Investigative Dermatology

Cell of Origin and Microenvironment Contribution for NF1-Associated Dermal Neurofibromas

Malignant peripheral nerve sheath tumor: models, biology, and translation

Epithelial stem cell homeostasis in Meibomian gland development, dysfunction, and dry eye disease

Tumorigenesis in neurofibromatosis type 1: role of the microenvironment

Insights into the Pathogenesis of NF1-Associated Neoplasms

Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins

Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling

Neurofibromin and suppression of tumorigenesis: beyond the GAP

Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A

Association of plexiform and diffuse neurofibromas with malignant peripheral nerve sheath tumor in NF I patients: a whole-body MRI assessment

Diffusion-weighted imaging and diffusion tensor imaging as adjuncts to conventional MRI for the diagnosis and management of peripheral nerve sheath tumors: current perspectives and future directions

STING activation reprograms the microenvironment to sensitize NF1-related malignant peripheral nerve sheath tumors for immunotherapy

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