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Drugging Undruggable Molecular Cancer Targets

Annual review of pharmacology and toxicology, 2016-01, Vol.56 (1), p.23-40

2016

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Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z

PloS one, 2010-11, Vol.5 (11), p.e15460

2010

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Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer

PloS one, 2013-03, Vol.8 (3), p.e58300

2013

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microRNA-21 Negatively Regulates Cdc25A and Cell Cycle Progression in Colon Cancer Cells

Cancer research (Chicago, Ill.), 2009-10, Vol.69 (20), p.8157-8165

2009

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Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations

The FEBS journal, 2023-10, Vol.290 (20), p.4950-4965

2023

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The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells

American journal of physiology. Lung cellular and molecular physiology, 2021-08, Vol.321 (2), p.L477-L484

2021

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The hubris and humility of cancer pharmacology in the post immuno‐oncology era

Pharmacology research & perspectives, 2019-12, Vol.7 (6), p.e00527-n/a

Lazo, John S.

2019

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Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor

Organic & biomolecular chemistry, 2016-01, Vol.14 (27), p.6398-6402

2016

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Low molecular weight inhibitors of Myc-Max interaction and function

Oncogene, 2003-09, Vol.22 (40), p.6151-6159

2003

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The Substrate Recognition Domains of the N-end Rule Pathway

The Journal of biological chemistry, 2009-01, Vol.284 (3), p.1884-1895

2009

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PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells

Cancer research (Chicago, Ill.), 2007-01, Vol.67 (2), p.643-650

2007

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Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase

The Journal of pharmacology and experimental therapeutics, 2019-12, Vol.371 (3), p.652-662

2019

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In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization

The Journal of pharmacology and experimental therapeutics, 2010-12, Vol.335 (3), p.715-727

2010

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Cutting down the time to identify challenging tumor therapeutic targets and drug combinations using synthetic lethal approaches [version 1; peer review: 2 approved]

F1000 research, 2018, Vol.7, p.308-308

Lazo, John S

2018

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Improved low molecular weight Myc-Max inhibitors

Molecular cancer therapeutics, 2007-09, Vol.6 (9), p.2399-2408

2007

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Potent and Selective Disruption of Protein Kinase D Functionality by a Benzoxoloazepinolone

The Journal of biological chemistry, 2008-11, Vol.283 (48), p.33516-33526

2008

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Discovery of Benzisothiazolone Derivatives as Bifunctional Inhibitors of HIV-1 Reverse Transcriptase DNA Polymerase and Ribonuclease H Activities

Biomolecules (Basel, Switzerland), 2024-07, Vol.14 (7), p.819

2024

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Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production

International journal of molecular sciences, 2020-04, Vol.21 (7), p.2530

2020

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The Benzo[c]phenanthridine Alkaloid, Sanguinarine, Is a Selective, Cell-active Inhibitor of Mitogen-activated Protein Kinase Phosphatase-1

The Journal of biological chemistry, 2005-05, Vol.280 (19), p.19078-19086

2005

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Diallyl trisulfide-induced G2-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc25C

Oncogene, 2005-09, Vol.24 (41), p.6256-6268

2005

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An acute respiratory distress syndrome drug development collaboration stimulated by the Virginia Drug Discovery Consortium

SLAS discovery, 2023-09, Vol.28 (6), p.249-254

2023

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High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons

SLAS discovery, 2023-09, Vol.28 (6), p.275-283

2023

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Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice

Cancer chemotherapy and pharmacology, 2009-03, Vol.63 (4), p.615-625

2009

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Identification of Survival Genes in Human Glioblastoma Cells by Small Interfering RNA Screening

Molecular pharmacology, 2009-12, Vol.76 (6), p.1246-1255

2009

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Induction of Cdc25B regulates cell cycle resumption after genotoxic stress

Cancer research (Chicago, Ill.), 2007-04, Vol.67 (7), p.3356-3363

2007

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Drugging Undruggable Molecular Cancer Targets

Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z

Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer

microRNA-21 Negatively Regulates Cdc25A and Cell Cycle Progression in Colon Cancer Cells

Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations

The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells

The hubris and humility of cancer pharmacology in the post immuno‐oncology era

Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor

Low molecular weight inhibitors of Myc-Max interaction and function

The Substrate Recognition Domains of the N-end Rule Pathway

PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells

Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase

In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization

Cutting down the time to identify challenging tumor therapeutic targets and drug combinations using synthetic lethal approaches [version 1; peer review: 2 approved]

Improved low molecular weight Myc-Max inhibitors

Potent and Selective Disruption of Protein Kinase D Functionality by a Benzoxoloazepinolone

Discovery of Benzisothiazolone Derivatives as Bifunctional Inhibitors of HIV-1 Reverse Transcriptase DNA Polymerase and Ribonuclease H Activities

Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production

The Benzo[c]phenanthridine Alkaloid, Sanguinarine, Is a Selective, Cell-active Inhibitor of Mitogen-activated Protein Kinase Phosphatase-1

Diallyl trisulfide-induced G2-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc25C

An acute respiratory distress syndrome drug development collaboration stimulated by the Virginia Drug Discovery Consortium

High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons

Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice

Identification of Survival Genes in Human Glioblastoma Cells by Small Interfering RNA Screening

Induction of Cdc25B regulates cell cycle resumption after genotoxic stress

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